Journal of Composites Science,
Год журнала:
2023,
Номер
7(5), С. 199 - 199
Опубликована: Май 15, 2023
Medical
implants
are
essential
tools
for
treating
chronic
illnesses,
restoring
physical
function,
and
improving
the
quality
of
life
millions
patients
worldwide.
However,
implant
failures
due
to
infection,
mechanical
wear,
corrosion,
tissue
rejection
continue
be
a
major
challenge.
Nanocomposites,
composed
nanoparticles
or
nanofillers
dispersed
in
matrix
material,
have
shown
promising
results
enhancing
performance.
This
paper
provides
an
overview
current
state
research
on
use
nanocomposites
medical
implants.
We
discuss
types
being
developed,
including
polymer-,
metal-,
ceramic-based
materials,
their
advantages/disadvantages
applications.
Strategies
performance
using
nanocomposites,
such
as
biocompatibility
properties
reducing
wear
also
examined.
Challenges
widespread
discussed,
biocompatibility,
toxicity,
long-term
stability,
standardisation,
control.
Finally,
we
future
directions
research,
advanced
fabrication
techniques
development
novel
nanocomposite
materials.
The
has
potential
improve
patient
outcomes
advance
healthcare,
but
continued
will
required
overcome
challenges
associated
with
use.
Advanced Materials,
Год журнала:
2022,
Номер
35(10)
Опубликована: Дек. 28, 2022
Abstract
Real‐time
monitoring
of
human
health
can
be
significantly
improved
by
designing
novel
electronic
skin
(E‐skin)
platforms
that
mimic
the
characteristics
and
sensitivity
skin.
A
high‐quality
E‐skin
platform
simultaneously
monitor
multiple
physiological
metabolic
biomarkers
without
introducing
discomfort
or
irritation
is
an
unmet
medical
need.
Conventional
E‐skins
are
either
monofunctional
made
from
elastomeric
films
do
not
include
key
synergistic
features
natural
skin,
such
as
multi‐sensing,
breathability,
thermal
management
capabilities
in
a
single
patch.
Herein,
biocompatible
biodegradable
patch
based
on
flexible
gelatin
methacryloyl
aerogel
(FGA)
for
non‐invasive
continuous
interest
engineered
demonstrated.
Taking
advantage
cryogenic
temperature
treatment
slow
polymerization,
FGA
fabricated
with
highly
interconnected
porous
structure
displays
good
flexibility,
passive‐cooling
capabilities,
ultra‐lightweight
properties
make
it
comfortable
to
wear
long
periods
time.
It
also
provides
numerous
permeable
capillary
channels
thermal‐moisture
transfer,
ensuring
its
excellent
breathability.
Therefore,
FGA‐based
body
temperature,
hydration,
biopotentials
via
electrophysiological
sensors
detect
glucose,
lactate,
alcohol
levels
electrochemical
sensors.
This
work
offers
previously
unexplored
materials
strategy
next‐generation
superior
practicality.
Metals,
Год журнала:
2022,
Номер
12(4), С. 687 - 687
Опубликована: Апрель 16, 2022
Ti-6Al-4V
(Ti64)
alloy
is
one
of
the
most
widely
used
orthopedic
implant
materials
due
to
its
mechanical
properties,
corrosion
resistance,
and
biocompatibility
nature.
Porous
Ti64
structures
are
gaining
more
research
interest
as
bone
implants
they
can
help
in
reducing
stress-shielding
effect
when
compared
their
solid
counterpart.
The
literature
shows
that
porous
fabricated
using
different
additive
manufacturing
(AM)
process
routes,
such
laser
powder
bed
fusion
(L-PBF)
electron
beam
melting
(EBM)
be
tailored
mimic
properties
natural
bone.
This
review
paper
categorizes
designs
into
non-gradient
(uniform)
gradient
(non-uniform)
structures.
Gradient
design
appears
promising
for
applications
closeness
towards
morphology
improved
properties.
In
addition,
this
outlines
details
on
structure
fatigue
behavior,
multifunctional
designs,
current
challenges,
gaps
studies
implants.
Biomacromolecules,
Год журнала:
2023,
Номер
25(4), С. 2075 - 2113
Опубликована: Июль 5, 2023
The
field
of
bone
tissue
engineering
has
seen
significant
advancements
in
recent
years.
Each
year,
over
two
million
transplants
are
performed
globally,
and
conventional
treatments,
such
as
grafts
metallic
implants,
have
their
limitations.
Tissue
offers
a
new
level
treatment,
allowing
for
the
creation
living
within
biomaterial
framework.
Recent
advances
biomaterials
provided
innovative
approaches
to
rebuilding
function
after
damage.
Among
them,
gelatin
methacryloyl
(GelMA)
hydrogel
is
emerging
promising
supporting
cell
proliferation
regeneration,
GelMA
exhibited
exceptional
physicochemical
biological
properties,
making
it
viable
option
clinical
translation.
Various
methods
classes
additives
been
used
application
with
incorporation
nanofillers
or
other
polymers
enhancing
its
resilience
functional
performance.
Despite
results,
fabrication
complex
structures
that
mimic
architecture
provision
balanced
physical
properties
both
vasculature
growth
proper
stiffness
load
bearing
remain
challenges.
In
terms
utilizing
osteogenic
additives,
priority
should
be
on
versatile
components
promote
angiogenesis
osteogenesis
while
reinforcing
structure
applications.
This
review
focuses
efforts
advantages
GelMA-based
composite
engineering,
covering
literature
from
last
five
Additive manufacturing,
Год журнала:
2024,
Номер
81, С. 104010 - 104010
Опубликована: Янв. 30, 2024
Isotropy
is
a
desired
characteristic
in
cellular
structures
for
load
bearing
and
energy
absorption
applications
that
must
respond
uniformly
under
external
loads
all
orientations.
Triply
periodic
minimal
surface
(TPMS)
are
attracting
much
attention
such
due
to
their
demonstrated
high
performance,
tailorable
properties,
open
cell
architecture.
However,
TPMS
usually
display
stiffness
anisotropy.
In
this
work,
new
design
strategies
presented
isotropic
TPMS-based
structures,
revealing
large
available
space
terms
of
relative
density
stiffness.
The
first
strategy
arranges
cells
Simple-Cubic/Face-Centred
Cubic
inspired
pattern,
resulting
reduced
elastic
Two
parametric
optimisation
approaches
involving
level-set
mid-surface
offsetting
the
functional
grading
then
applied
second
step
eliminate
any
residual
Anisotropy
characterised
through
finite
element
analysis
using
Zener
ratio.
Four
families
optimised,
each
based
on
different
unit
cell,
additively
manufactured
material
extrusion
process
with
polylactic
acid.
Finally,
experimental
quasi-static
compressive
tests
conducted
characterise
stiffness,
strength,
properties.
Optimised
designs
tested
three
crystal
orientations
([001],
[101]
[111])
orthogonal
print
Primitive
stiffest
four
reaching
64.4%
Hashin-Shtrikman
upper
bound
bulk
modulus
at
20%
density.
Experimental
results
validate
optimised
isotropy
indicate
also
crushing
strength
absorption.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Год журнала:
2021,
Номер
124, С. 104804 - 104804
Опубликована: Авг. 30, 2021
Triply
periodic
minimal
surfaces
(TPMS)
are
mathematically
defined
cellular
structures
whose
geometry
can
be
quickly
adapted
to
target
desired
mechanical
response
(structural
and
fluid).
This
has
made
them
desirable
for
a
wide
range
of
bioengineering
applications;
especially
as
bioinspired
materials
bone
replacement.
The
main
objective
this
study
was
develop
novel
analytical
framework
which
would
enable
calculating
permeability
TPMS
based
on
the
architecture,
pore
size
porosity.
To
achieve
this,
computer-aided
designs
three
(Fisher-Koch
S,
Gyroid
Schwarz
P)
were
generated
with
varying
cell
porosity
levels.
Computational
Fluid
Dynamics
(CFD)
used
calculate
all
models
under
laminar
flow
conditions.
Permeability
values
then
fit
an
model
dependent
parameters
only.
Results
showed
that
architectures
increased
at
different
rates,
highlighting
importance
distribution
architecture.
computed
fitted
well
suggested
(R2>0.99,
p<0.001).
In
conclusion,
presented
in
current
enables
predicting
geometrical
within
difference
<5%.
model,
could
combined
existing
structural
models,
open
new
possibilities
smart
optimisation
biomedical
applications
where
fluid
properties
need
optimised.
Journal of Materials Research and Technology,
Год журнала:
2022,
Номер
18, С. 3240 - 3255
Опубликована: Апрель 14, 2022
Porosity
is
considered
to
be
one
of
the
key
factors
affecting
structural
properties
porous
lattices,
but
in
fact,
pore
size
also
plays
an
important
role,
and
it
has
great
potential
adjust
porosity
independently
improve
properties.
In
this
work,
by
adjusting
sheet
thickness
triply
periodic
minimal
surface
(TPMS)
lattice
structures
height
single
row
structure
according
linear
constant
laws,
TPMS
with
given
adjustable
are
designed,
mechanical
response
investigated.
Based
on
preparing
samples
Ti6Al4V
laser
powder
bed
fusion,
results
tests
show
that
elastic
modulus
ranges
change
(LC-TPMS)
(C-TPMS)
3625.6
MPa–4575.1
MPa
3820.0
MPa–4509.1
MPa,
respectively.
plateau
stage,
LC-TPMS
have
a
longer
more
stable
higher
yield
stress
better
energy
absorption
capacity
than
C-TPMS
structures.
The
maximum
difference
62.7
MJ/mm3
efficiency
0.12.
can
obtain
larger
damping
ratio
under
compressive
strain.
