Combinatorial Polydopamine-Liposome Nanoformulation as an Effective Anti-Breast Cancer Therapy

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 861 - 879

Опубликована: Фев. 1, 2023

Drug delivery systems (DDSs) based on liposomes are potential tools to minimize the side effects and substantially enhance therapeutic efficacy of chemotherapy. However, it is challenging achieve biosafe, accurate, efficient cancer therapy with single function or mechanism. To solve this problem, we designed a multifunctional multimechanism nanoplatform polydopamine (PDA)-coated for accurate combinatorial chemotherapy laser-induced PDT/PTT.ICG DOX were co-incorporated in polyethylene glycol modified liposomes, which further coated PDA by facile two-step method construct PDA-liposome nanoparticles (PDA@Lipo/DOX/ICG). The safety nanocarriers was investigated normal HEK-293 cells, cellular uptake, intracellular ROS production capacity, treatment effect assessed human breast cells MDA-MB-231. In vivo biodistribution, thermal imaging, biosafety assessment, combination estimated MDA-MB-231 subcutaneous tumor model.Compared DOX·HCl Lipo/DOX/ICG, PDA@Lipo/DOX/ICG showed higher toxicity cells. After endocytosis target produced large amount PDT 808 nm laser irradiation, cell inhibition rate reached up 80.4%. tail vein injection (DOX equivalent 2.5 mg/kg) mice bearing tumors, significantly accumulated at site 24 h post injection. irradiation (1.0 W/cm2, 2 min) timepoint, efficiently suppressed proliferation even thoroughly ablated tumors. Negligible cardiotoxicity no treatment-induced observed.PDA@Lipo/DOX/ICG PDA-coated PDT/PTT.

Язык: Английский

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Tannic Acid-Modified Decellularized Tendon Scaffold with Antioxidant and Anti-Inflammatory Activities for Tendon Regeneration

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(13), С. 15879 - 15892

Опубликована: Март 26, 2024

Tendon regeneration is greatly influenced by the oxidant and inflammatory microenvironment. Persistent inflammation during tendon repair can cause matrix degradation, adhesion, excessive accumulation of reactive oxygen species (ROS), while ROS affect extracellular remodeling integration. Herein, we used tannic acid (TA) to modify a decellularized slice (DTS) fabricate functional scaffold (DTS-TA) with antioxidant anti-inflammatory properties for repair. The characterizations cytocompatibility scaffolds were examined in vitro. activities evaluated vitro further studied vivo using subcutaneous implantation model. It was found that modified DTS combined TA via hydrogen bonds covalent bonds, hydrophilicity, thermal stability, biodegradability, mechanical characteristics significantly improved. Afterward, results demonstrated DTS-TA could effectively reduce increasing M2/M1 macrophage ratio interleukin-4 (IL-4) expression, decreasing secretion interleukin-6 (IL-6) interleukin-1β (IL-1β), as well scavenging vivo. In summary, provides potential versatile regeneration.

Язык: Английский

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Electrospinning of Sustainable Polymers from Biomass for Active Food Packaging

Sustainable Food Technology, Год журнала: 2024, Номер 2(5), С. 1266 - 1296

Опубликована: Янв. 1, 2024

This review outlines the latest developments in using electrospun materials derived from sustainable, biomass-sourced polymers for active food packaging applications.

Язык: Английский

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Use of antioxidants to retard aging of bitumen: A review

Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(36), С. 48839 - 48863

Опубликована: Июль 26, 2024

Язык: Английский

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Green and multifunctional chitosan-based conformal coating as a controlled release platform for fruit preservation

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 219, С. 767 - 778

Опубликована: Авг. 10, 2022

Язык: Английский

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Mechanochemical Applications of Reactive Extrusion from Organic Synthesis to Catalytic and Active Materials

Molecules, Год журнала: 2022, Номер 27(2), С. 449 - 449

Опубликована: Янв. 10, 2022

In the past, use of mechanochemical methods in organic synthesis was reported as somewhat a curiosity. However, perceptions have changed over last two decades, and this technology is now being appreciated greener more efficient synthetic method. The qualified "offer" ball mills that make different set-ups, materials, dimensions has allowed to mature. Nevertheless, intrinsic batch nature hinders industrial scale-ups. New studies found, reactive extrusion, powerful technique with which activate chemical reactions mechanical forces continuous flow. This new environmentally friendly method may be able miniaturize production plants outstanding process intensifications by removing solvents working flow mode. Compared conventional processes, extrusions display high simplicity, safety, cleanliness, can exploited variety applications. paper presents perspective examples better-known areas extrusions, including oxidation reactions, polymer processing, biomass conversion. work should stimulate further developments, it highlights versatility extrusion huge potential solid-phase chemistry.

Язык: Английский

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Natural Antioxidant and Antimicrobial Agents and Processing Technologies for the Design of Active Food Packaging Polymers

Polymer Reviews, Год журнала: 2023, Номер 63(4), С. 961 - 1013

Опубликована: Июль 13, 2023

Over the last decades, food packaging has advanced significantly, which is crucial in maintaining safety and minimizing waste. However, most traditional materials market are typically made of inexpensive synthetic plastics with a limited scope providing physical containment an effective barrier against moisture gases. In contrast, sustainable active offers promising solution to extend shelf-life by effectively decreasing rate oxidative deterioration microbial growth while reducing environmental impact petrochemical-derived plastics. As result, there significant interest developing low carbon footprint. Natural resource-derived antioxidant antimicrobial agents better alternatives when combined any biodegradable polymer as it enhances sustainability portfolio. This review critically evaluates recent trends natural for applications. Various biobased reviewed discussed, including their structure, physico-chemical properties, various attributes Finally, this presents outlook on future highlights potential challenges development implementation.

Язык: Английский

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Towards weathering and corrosion resistant, self-warning and self-healing epoxy coatings with tannic acid loaded nanocontainers

npj Materials Degradation, Год журнала: 2023, Номер 7(1)

Опубликована: Май 20, 2023

Abstract In this work, an active protective epoxy coating with weathering resistant, corrosion-warning, and self-healing properties was developed by incorporating tannic acid (TA) loaded mesoporous silica (MSN-TA) nanocontainers. The introduction of MSN-TA nanocontainers could alleviate the degradation via scavenging radicals generated during UV irradiation. Compared blank coating, containing 5 wt.% exhibited much less in surface morphology, wettability glossiness, maintained a good barrier property after 384 h accelerated weathering. Once damaged, released TA react Fe 3+ ions to form chelate that endowed scratch visible black coloration, i.e. triggering self-warning capability indicate initial onset corrosion. addition, inhibit extensive corrosion propagation, offering significant effect demonstrated stabilized impedance modulus values 28 days immersion NaCl solution.

Язык: Английский

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Antibacterial photodynamic properties of silver nanoparticles-loaded curcumin composite material in chitosan-based films

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 256, С. 128014 - 128014

Опубликована: Ноя. 10, 2023

Язык: Английский

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Machine learning for polyphenol-based materials

Smart Materials in Medicine, Год журнала: 2024, Номер 5(2), С. 221 - 239

Опубликована: Фев. 11, 2024

Язык: Английский

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