International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 131914 - 131914
Опубликована: Май 3, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Июль 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Язык: Английский
Процитировано
120
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Май 31, 2023
Abstract Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the development a biofunctional hydrogel improved delivery required. In this study, we introduce liposome-anchored teriparatide (PTH (1–34)) incorporated into gallic acid-grafted gelatin injectable (GLP hydrogel). We show that GLP can form in situ and without affecting knee motion after intra-articular mice. demonstrate controlled, sustained release PTH (1–34) from hydrogel. find promotes ATDC5 cell proliferation protects IL-1β-induced cells further OA progression regulating PI3K/AKT signaling pathway. Further, hydrogels OA-induced mouse model glycosaminoglycans synthesis cartilage degradation, supporting potential biomaterial treatment.
Язык: Английский
Процитировано
116
Bioactive Materials, Год журнала: 2024, Номер 34, С. 298 - 310
Опубликована: Янв. 3, 2024
Mesenchymal stem cell derived exosomes (MSC-Exos) demonstrate beneficial effects on wound healing via anti-inflammatory and angiogenic properties. Chitosan (CS) exhibits excellent biocompatibility accelerates cellular migration, adhesion, proliferation. The ions released from bioactive glass (BG) titanium dioxide (TiO
Язык: Английский
Процитировано
72
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(16), С. 19951 - 19965
Опубликована: Апрель 12, 2023
Critical-size bone defects are an important problem in clinical practice, which usually occurs severe trauma, or tumor resection, and cannot heal completely autonomously. Implantation of grafts is often required to promote the regeneration critical-size defects. Metal ions play role human health, as they affect body's metabolism tissue function. Strontium (Sr2+) can osteogenesis angiogenesis. Herein, we prepared nano-hydroxyapatite (nHA)/chitosan (CS) composite microspheres with a uniform particle size distribution extracellular matrix-like nanofiber structure using microfluidic technology direct alkali-induced gelation. were stably added into by polydopamine (PDA) chelate metal forming repair material (nHA/CS@PDA-Sr) good bioactivity. The coordination reaction PDA effectively control release strontium avoid negative effects caused high concentration. Our vitro experiments showed that had biocompatibility coating promotes cell adhesion. slow mesenchymal stem cells osteogenic differentiation vascularization endothelial cells. In addition, injected cranial rats evaluate osseointegration vivo. results nHA/CS@PDA-Sr could defect area. This study demonstrates stimulate providing promising way for bone-defect regeneration.
Язык: Английский
Процитировано
57
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 246, С. 125674 - 125674
Опубликована: Июль 4, 2023
Язык: Английский
Процитировано
53
Bioactive Materials, Год журнала: 2023, Номер 32, С. 149 - 163
Опубликована: Окт. 6, 2023
Soft hydrogels are excellent candidate materials for repairing various tissue defects, yet the mechanical strength, anti-swelling properties, and biocompatibility of many soft need to be improved. Herein, inspired by nanostructure collagen fibrils, we developed a strategy toward achieving but tough, nanofibrillar hydrogel combining self-assembly chemical crosslinking nanoparticles. Specifically, fibril-like injectable was subtly designed fabricated self-assembling methylacrylyl hydroxypropyl chitosan (HM) with laponite (LAP) form nanoparticles, followed inter-nanoparticle bonding through photo-crosslinking. The assembly mechanism nanoparticles elucidated both experimental simulation techniques. Due unique structure crosslinked nanocomposite exhibited low stiffness (G'< 2 kPa), high compressive strength (709 (swelling ratio 1.07 in PBS) properties. Additionally, harnessing photo-crosslinking ability were processed as microgels, which can three-dimensionally (3D) printed into complex shapes. Furthermore, demonstrated that these highly biocompatible, biodegradability, effectively promote fibroblast migration accelerate blood vessel formation during wound healing. This work presents promising approach develop biomimetic, regenerative medicine applications.
Язык: Английский
Процитировано
52
Bone Research, Год журнала: 2024, Номер 12(1)
Опубликована: Май 14, 2024
Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and impaired restoration of deficiencies are major challenges treatment. Microbes have evolved numerous mechanisms to effectively evade host intrinsic adaptive immune attacks persistently localize the host, such as drug-resistant bacteria, biofilms, persister cells, intracellular small colony variants (SCVs). Moreover, microbial-mediated dysregulation microenvironment impedes regeneration process, leading defect repair. Despite advances surgical strategies drug applications for treatment infections within last decade, remain clinical management. The development application tissue engineering materials provided new infections, but comprehensive review their research progress lacking. This discusses critical pathogenic microbes skeletal system immunomodulatory effects on regeneration, highlights prospects technologies infections. It will inform translation antimicrobial repair management
Язык: Английский
Процитировано
50
Gels, Год журнала: 2023, Номер 9(5), С. 373 - 373
Опубликована: Май 1, 2023
Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds, mainly due to the advantages their chemical and physical properties. This review focuses on application chitosan scaffolds for vascular regeneration. We introduced these following aspects: progress regeneration modification improve Finally, this paper discusses prospects
Язык: Английский
Процитировано
49
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(30)
Опубликована: Июль 22, 2024
Abstract Due to repeated microbial infection, persistent inflammation, excessive oxidative stress, and cell dysfunction, chronic wounds are difficult heal, posing a serious threat public health. Therefore, developing multifunctional wound dressings that can regulate the complex microenvironment of enhance cellular function holds great significance. Recently, chitosan has emerged as promising biopolymer for healing due its excellent biocompatibility, biodegradability, versatile bioactivity. The aim this review is provide comprehensive understanding mechanisms delayed discuss healing–promoting properties derivatives, such good antibacterial activity, hemostatic capacity, ability promote tissue regeneration. On basis, potential applications chitosan‐based hydrogels summarized in healing, including providing suitable microenvironment, eliminating bacterial infections, promoting hemostasis, inhibiting alleviating In addition, concerns perspectives clinical application also discussed.
Язык: Английский
Процитировано
32
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129300 - 129300
Опубликована: Янв. 11, 2024
Язык: Английский
Процитировано
29