Optics Express, Год журнала: 2024, Номер 32(17), С. 29265 - 29265
Опубликована: Июль 24, 2024
The longitudinal relaxation time (termed as T
Язык: Английский
Nanoscale, Год журнала: 2024, Номер 16(24), С. 11610 - 11622
Опубликована: Янв. 1, 2024
Nanomedicine aims to develop smart approaches for treating cancer and other diseases improve patient survival quality of life. Novel nanoparticles as nanodiamonds (NDs) represent promising candidates overcome current limitations. In this study, NDs were functionalized with a 200 kDa hyaluronic acid-phospholipid conjugate (HA/DMPE), enhancing the stability in water-based solutions selectivity cells overexpressing specific HA cluster determinant 44 (CD44) receptors. These characterized by diffuse reflectance Fourier-transform infrared spectroscopy, Raman photoluminescence confirming efficacy functionalization process. Scanning electron microscopy was employed evaluate size distribution dry particles, while dynamic light scattering zeta potential measurements utilized ND behavior medium. Furthermore, biocompatibility uptake mediated CD44 receptors three different models human adenocarcinoma assessed performing cytofluorimetric assay confocal microscopy. HA-functionalized demonstrated advantage active targeting presence expressing on surface, suggesting higher drug delivery tumors over non-tumor tissues. Even CD44-poorly cancers could be targeted NDs, thanks their good passive diffusion within cells.
Язык: Английский
Процитировано
3
Carbon, Год журнала: 2024, Номер 228, С. 119405 - 119405
Опубликована: Июнь 30, 2024
Cell migration is a crucial parameter for disease progression in cancer. Reactive oxygen species (ROS) levels are involved the regulation of process, however, exact role free radical generation and where it occurs unknown. Here we use diamond-based quantum sensing technique to detect radicals during cancer cell real time with subcellular resolution. We investigated metastatic MDA-MB-231 human breast cells observed formation after 16 h starvation 24 under low-serum conditions. Intracellular diamond dynamics were monitored at different points (0, 12, h), morphology was evaluated. Additionally, number focal adhesions analyzed as an indicator migratory potential cells. further measured nicotinamide adenine dinucleotide phosphate hydrogen NADPH oxidases 2 (NOX2) inhibition by apocynin. found that decreased treatment 36 μg/mL apocynin while ROS capacity increased. Our results evidence complexity redox migrating offer novel approach specifically locally interrogate pivotal players oxidative network behind success.
Язык: Английский
Процитировано
3
Nanoscale, Год журнала: 2024, Номер 16(32), С. 14994 - 15008
Опубликована: Янв. 1, 2024
Cancer has become a primary global health concern, which prompted increased attention towards targeted therapeutic approaches like photothermal therapy (PTT). The unique optical and magnetic properties of nanodiamonds (NDs) have made them versatile nanomaterials with promising applications in biomedicine. This comprehensive review focuses on the potential NDs as multifaceted platform for anticancer therapy, mainly focusing their dual functionality PTT temperature sensing. highlighted NDs' ability to enhance through hybridization or modification, underscoring adaptability delivering small molecule reagents effectively. Furthermore, NDs, particularly fluorescent (FNDs) negatively charged nitrogen-vacancy centers, enable precise monitoring, enhancing efficacy treatment. Integrating FNDs into holds promise advancing by providing valuable insights localized variations cell death mechanisms. highlights new cancer treatment strategies, showcasing revolutionize therapeutics improve patient outcomes.
Язык: Английский
Процитировано
3
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 147 - 172
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Chemical & Biomedical Imaging, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 9(1)
Опубликована: Март 4, 2025
Tooth extraction, while essential for oral health, can contribute to systemic complications, particularly increasing cardiovascular risk due bacterial translocation and inflammation. Periodontal disease, a major cause of tooth loss, exacerbates this by serving as reservoir pathogenic bacteria that enter the bloodstream during extractions. This review explores mechanisms linking post-extraction infections diseases evaluates role nanotechnology in mitigating these risks. Advances antimicrobial nanoparticles, nanodrug delivery systems, biosensors offer promising solutions infection control targeted drug delivery. These innovations enhance healing potentially reducing However, challenges remain optimizing material biocompatibility, ensuring clinical efficacy, addressing translational hurdles. underscores need interdisciplinary research integrate into dental practice, ultimately improving both health outcomes.
Язык: Английский
Процитировано
0
Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114313 - 114313
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Advanced Drug Delivery Reviews, Год журнала: 2025, Номер 221, С. 115590 - 115590
Опубликована: Апрель 15, 2025
Язык: Английский
Процитировано
0
IntechOpen eBooks, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Over the past decade, fluorescent nanodiamonds (FNDs) have emerged as a transformative class of carbon-based nanomaterials, distinguished by their unique crystallographic defect structures containing optically active color centers. These centers confer superior photophysical properties compared to conventional organic fluorophores, including exceptional photostability, inherent biocompatibility, and remarkable optical-mechanical robustness. The versatile surface chemistry, characterized abundant functional groups an extensive specific area, has enabled diverse biomedical applications, ranging from super-resolution bioimaging targeted drug delivery precision cancer theranostics quantum-based nanothermometry. This comprehensive review systematically examines contemporary synthesis strategies for FND fabrication, critically analyzes technical challenges in engineering functionalization, elucidates structure-property relationships that underpin biological applications. By integrating fundamental principles with cutting-edge developments, this work aims provide strategic framework advancing FND-based technologies nanomedicine quantum biosensing.
Язык: Английский
Процитировано
0
Advanced Drug Delivery Reviews, Год журнала: 2025, Номер 222, С. 115593 - 115593
Опубликована: Май 6, 2025
Язык: Английский
Процитировано
0