Rational formulation of saponin and dexamethasone for the synergistic treatment of rheumatoid arthritis in vivo DOI

Yaru Yue,

Zhengquan Liao,

Yingqian Zhou

и другие.

Applied Materials Today, Год журнала: 2024, Номер 40, С. 102381 - 102381

Опубликована: Авг. 20, 2024

Язык: Английский

Ce1−xZrxO2 nanoparticles in bacterial cellulose, bio-based composites with self-regenerating antioxidant capabilities DOI Creative Commons
Johanna van Gent, Anna Roig

Nanoscale, Год журнала: 2023, Номер 15(31), С. 13018 - 13024

Опубликована: Янв. 1, 2023

Nanocomposite antioxidant effectiveness depends on the Ce 3+ /Ce 4+ equilibrium population.

Язык: Английский

Процитировано

5
Hierarchical Microcarriers Loaded with Peptide Dendrimer‐Grafted Methotrexate for Rheumatoid Arthritis Treatment DOI Creative Commons
Yang Li,

Haofang Zhu,

Rui Liu

и другие.

Small Science, Год журнала: 2023, Номер 4(1)

Опубликована: Ноя. 27, 2023

Rheumatoid arthritis (RA) is one of the leading causes disability due to autoimmune destruction synovial joints. Great efforts have been put into developing multifunctional drug delivery systems for delaying progression RA. Herein, a novel locally injectable, hierarchically structured system with hyaluronic acid (HA) microparticle and an MTX‐conjugated nanoparticle promoted RA treatment proposed. In this system, MTX chemically grafted onto peptide dendrimer‐based (G‐MTX). These nanoparticles are encapsulated inside HA microparticles (H‐G‐MTX) using microfluidics realize system. The G‐MTX can be released from degradable in acidic environment inflamed As shows enhanced intracellular conjugated MTX, H‐G‐MTX reverse dominant macrophage phenotype M1 M2. Through collagen‐induced (CIA) rat model, great therapeutic outcomes demonstrated, including inflammation reduction, cartilage protection, bone mineral density promotion. results indicate that proposed hierarchical has potential clinical value other diseases.

Язык: Английский

Процитировано

5
Manganese-doped albumin-gelatin composite nanogel loaded with berberine applied to the treatment of gouty arthritis in rats via a SPARC-dependent mechanism DOI Creative Commons
Junpeng Sun,

Xiaobang Liu,

Jiaqun Du

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126999 - 126999

Опубликована: Сен. 18, 2023

In this study, manganese-doped albumin-gelatin composite nanogels (MAGN) were prepared and used to load berberine (Ber) for the treatment of gouty arthritis (GA). The nanodrug delivery system (Ber-MAGN) can target inflammatory joints due intrinsic high affinity albumin SPARC, which is overexpressed at site GA. Characterization pharmaceutical properties in vitro showed that Ber-MAGN had good dispersion, particle size was 121 ± 10.7 nm. sustained release effect significantly improved bioavailability berberine. vivo experimental results has better therapeutic effects relieving oxidative stress suppressing inflammation. Therefore, Ber-MAGN, as a potential preparation GA, provides new reference clinical plan

Язык: Английский

Процитировано

4
Integrating Pt nanoparticles with 3D Cu2-xSe/GO nanostructure to achieve nir-enhanced peroxidizing Nano-enzymes for dynamic monitoring the level of H2O2 during the inflammation DOI Creative Commons
Man Shen,

Xianling Dai,

Demchenko N.N.

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 17, 2024

The treatment of wound inflammation is intricately linked to the concentration reactive oxygen species (ROS) in microenvironment. Among these ROS, H

Язык: Английский

Процитировано

0
Rational formulation of saponin and dexamethasone for the synergistic treatment of rheumatoid arthritis in vivo DOI

Yaru Yue,

Zhengquan Liao,

Yingqian Zhou

и другие.

Applied Materials Today, Год журнала: 2024, Номер 40, С. 102381 - 102381

Опубликована: Авг. 20, 2024

Язык: Английский

Процитировано

0