Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 16, 2024
In
the
era
of
"Great
Health",
maintaining
an
appropriate
level
vitamin
C
is
crucial
for
human
health
as
it
directly
impacts
proper
functioning
immune
system.
this
study,
a
handheld
nonenzymatic
electrochemical
sensor
based
on
biomimetic
material
prussian
blue
functionalized
polydopamine
proposed
point-of-care
testing
(POCT)
in
fluids.
Particularly,
Prussian
blue,
known
bio-antidote,
and
polydopamine,
main
component
cuttlefish
ink,
ensure
safety
reliability
home
testing.
The
experimental
results
quantitatively
demonstrate
that
POCT
enables
rapid
accurate
determination
with
wide
linear
detection
range
from
0.2
to
200
µm,
low
limit
at
0.03
high
sensitivity
0.33
µA
µm-1
cm-2.
More
importantly,
performance
evaluation
using
urine
saliva
samples
confirms
satisfactory
accuracy
recovery
rates
by
sensor.
Thus,
holds
potential
utility
affordable
tool
VC
home-based
healthcare.
Hydrogel-based
wearable
electrochemical
biosensors
(HWEBs)
are
emerging
biomedical
devices
that
have
recently
received
immense
interest.
The
exceptional
properties
of
HWEBs
include
excellent
biocompatibility
with
hydrophilic
nature,
high
porosity,
tailorable
permeability,
the
capability
reliable
and
accurate
detection
disease
biomarkers,
suitable
device-human
interface,
facile
adjustability,
stimuli-responsive
to
nanofiller
materials.
Although
biomimetic
three-dimensional
hydrogels
can
immobilize
bioreceptors,
such
as
enzymes
aptamers,
without
any
loss
in
their
activities.
However,
most
suffer
from
low
mechanical
strength
electrical
conductivity.
Many
studies
been
performed
on
electroactive
nanofillers,
including
biomacromolecules,
carbon-based
materials,
inorganic
organic
nanomaterials,
tackle
these
issues.
Non-conductive
even
conductive
may
be
modified
by
nanofillers
well
redox
species.
All
modifications
led
design
development
efficient
nanocomposites
biosensors.
In
this
review,
both
conductive-based
non-conductive-based
derived
natural
synthetic
polymers
systematically
reviewed.
main
synthesis
methods
characterization
techniques
addressed.
behavior
discussed
detail.
Finally,
prospects
potential
applications
biosensing,
healthcare
monitoring,
clinical
diagnostics
highlighted.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(5), С. 4938 - 4945
Опубликована: Янв. 27, 2024
Monitoring
immune-supporting
micronutrients
such
as
vitamins
C
and
D
is
relevant
these
nutrients
are
involved
in
metabolic
pathways
to
fight
against
viruses
bacteria.
The
simultaneous
determination
of
biomarkers
the
same
sample
volume
challenging,
with
multistep
protocols
if
labels
redox
probes
required.
In
this
paper,
we
report
on
a
flexible
bioelectronic
chip
combining
25-hydroxyvitamin
D3
metabolite
(25(OH)D3)
immunoassay
an
electrocatalytic
assay
for
vitamin
C.
One
sensors
was
made
graphitic
carbon
nitride
modified
electroactive
dye
toluidine
blue,
decorated
electrodeposited
6.5
nm
gold
nanoparticles,
coated
layer
anti-25(OH)D3
antibodies.
With
sensor,
25(OH)D3
could
be
detected
via
chronoamperometry
at
concentrations
ranging
from
0.1
700
ng
mL–1
limit
detection
(LOD)
0.01
mL–1.
other
sensor
had
24.7
Pearls
nanoparticles
whose
electroactivity
permitted
range
1
140
μM,
LOD
0.12
μM.
Since
does
not
contain
or
probes,
it
has
potential
use
wearable
devices
track
bodily
fluids,
aiding
personalized
nutrition
by
preventing
deficiencies
toxicity.
Bimetallic
organic
frameworks
(Bi-MOFs)
have
been
recognized
as
one
of
the
hotpots
for
electrochemical
sensing
due
to
their
high
surface
area,
abundant
active
sites,
tunable
structures
and
porosity.
However,
issue
inadequate
conductivity
hidden
site
MOF
hindered
further
development
remain
great
challenges.
Here,
an
in-situ
co-precipitation
strategy
was
proposed
controlled
preparation
sophisticated
hierarchical
Bi-MOF
derivatives
with
enhanced
glucose
through
calcination.
Firstly,
uniform
CuO
nanorods
precursor
are
synthesized
in
situ
on
a
carbon
cloth
(CC)
wet
chemical
method
involving
sputter
coating.
Subsequently,
Cu-BTC
Co-BTC
were
co-precipitated
precursor,
while
significant
effect
incremental
Co
ion
doping
concentration
morphology
investigated.
Finally,
successfully
obtained
by
structural
transformation
during
annealing.
Due
synergistic
bimetallic
oxides
accessible
sites
derivatives,
prepared
electrode
exhibits
excellent
properties,
including
sensitivity
(4.93
mA
mM-1
cm-2),
fast
response
time
(2.9
s),
outstanding
long-term
stability
(30
days).
This
study
proposes
practical
synthesizing
which
provides
wide-ranging
prospects
field
sensing.
Journal of The Electrochemical Society,
Год журнала:
2024,
Номер
171(6), С. 067510 - 067510
Опубликована: Июнь 3, 2024
In
recent
years,
there
has
been
growing
demand
for
the
monitoring
of
ascorbic
acid
levels,
especially
in
underdeveloped
populations
where
deficiency
affects
up
to
74%
individuals.
To
facilitate
widespread
screening,
we
have
developed
a
highly
scalable
conductive
polymer
nanocomposite
with
excellent
sensing
performance.
The
material
is
based
on
polyaniline,
which
deposited
single
step
presence
polystyrene
sulfonate
and
multi-walled
carbon
nanotubes
onto
paper.
modified
electrodes
take
advantage
electrocatalytic
properties
polyaniline
toward
acid,
are
boosted
by
proton
donating
high
surface
area
nanotubes.
morphology
composition
composite
characterized
using
field-emission
scanning
electron
microscopy,
transmission
Raman
spectroscopy,
X-ray
photoelectron
spectroscopy
electrochemical
characteristics
examined
cyclic
voltammetry
impedance
spectroscopy.
electrode
shows
good
characteristics,
linear
range
1–400
μ
M,
sensitivity
546
A
mM
−1
cm
−2
,
limit
detection
0.11
M.
High
performance
low
cost
results
promising
platform
support
widespread,
cheap
deficiency.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 16, 2024
In
the
era
of
"Great
Health",
maintaining
an
appropriate
level
vitamin
C
is
crucial
for
human
health
as
it
directly
impacts
proper
functioning
immune
system.
this
study,
a
handheld
nonenzymatic
electrochemical
sensor
based
on
biomimetic
material
prussian
blue
functionalized
polydopamine
proposed
point-of-care
testing
(POCT)
in
fluids.
Particularly,
Prussian
blue,
known
bio-antidote,
and
polydopamine,
main
component
cuttlefish
ink,
ensure
safety
reliability
home
testing.
The
experimental
results
quantitatively
demonstrate
that
POCT
enables
rapid
accurate
determination
with
wide
linear
detection
range
from
0.2
to
200
µm,
low
limit
at
0.03
high
sensitivity
0.33
µA
µm-1
cm-2.
More
importantly,
performance
evaluation
using
urine
saliva
samples
confirms
satisfactory
accuracy
recovery
rates
by
sensor.
Thus,
holds
potential
utility
affordable
tool
VC
home-based
healthcare.
