An intelligent core–shell microneedle patch loaded with oxygen-vacancy-engineered ROS nanogenerators for a programmed ICB therapy against “cold” tumors

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160621 - 160621

Опубликована: Фев. 1, 2025

Язык: Английский

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Sericin and Gentamicin-Enhanced Polyurethane-Acrylate Adhesives for Superior Adhesion, Biocompatibility and Antibacterial Property

International Journal of Adhesion and Adhesives, Год журнала: 2025, Номер unknown, С. 103988 - 103988

Опубликована: Фев. 1, 2025

Язык: Английский

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A Dual‐Responsive Fe₃O₄@ZIF‐8 Nanoplatform Combining Magnetic Targeting and pH Sensitivity for Low Back Pain Therapy

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Low back pain (LBP) resulting from sciatic nerve compression presents major challenges in management, as traditional therapies provide only short-term relief and pose risks of systemic toxicity. In this study, an innovative Fe3O4@ZIF-8-RVC (FZR) dual-responsive nanoplatform is introduced that integrates magnetic targeting with pH-sensitive, sustained drug release to overcome these limitations. The FZR encapsulates ropivacaine (RVC) within the ZIF-8-coated Fe3O4 core, enabling precise prolonged analgesia at injury site through guidance acid-triggered release. vitro vivo assessments indicate achieves high loading, acidic environments, excellent biocompatibility, significantly extending analgesic effects chronic models while minimizing exposure. Behavioral tests molecular analyses LBP rat confirm effectively suppresses pain-related neuronal activity central sensitization markers. This offers a safe, long-lasting, targeted therapeutic approach, holding strong potential for advancing related neuropathic conditions.

Язык: Английский

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Freeform 3D Printing of Cell-Adsorptive Cryogels with Shape-Recoverability

ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 1152 - 1161

Опубликована: Фев. 24, 2025

Язык: Английский

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Magnesium-gallate MOF integrated conductive cryogel for inflammation regulation and boosting bone regeneration

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141672 - 141672

Опубликована: Март 3, 2025

Язык: Английский

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