Materials Today Bio, Год журнала: 2024, Номер 26, С. 101089 - 101089

Опубликована: Май 11, 2024

Catheter-associated urinary tract infection (CAUTI) is a common clinical problem, especially during long-term catheterization, causing additional pain to patients. The development of novel antimicrobial coatings needed prolong the service life catheters and reduce incidence CAUTIs. Herein, we designed an catheter coated with piezoelectric zinc oxide nanoparticles (ZnO NPs)-incorporated polyvinylidene difluoride-hexafluoropropylene (ZnO-PVDF-HFP) membrane. ZnO-PVDF-HFP could be stably onto silicone simply by one-step solution film-forming method, very convenient for industrial production. In vitro, it was demonstrated that coating significantly inhibit bacterial growth formation biofilm under ultrasound-mediated mechanical stimulation even after 4 weeks. Importantly, on off activity as well strenth antibacterial property controlled in adaptive manner via ultrasound. rabbit model, ZnO-PVDF-HFP-coated reduced CAUTIs compared clinically-commonly used assistance ultrasonication, no side effect detected. Collectively, study provided prevent occurance CAUTIs, whose on-demand manner, situation promising application.

Язык: Английский