International Journal of Pharmaceutics, Год журнала: 2025, Номер 673, С. 125375 - 125375
Опубликована: Фев. 16, 2025
Язык: Английский
Food Hydrocolloids, Год журнала: 2024, Номер 155, С. 110192 - 110192
Опубликована: Май 14, 2024
Язык: Английский
Процитировано
3
Food & Function, Год журнала: 2024, Номер 15(18), С. 9085 - 9099
Опубликована: Янв. 1, 2024
The onset and progression of ulcerative colitis (UC) are intricately linked to the worsening intestinal inflammation, an imbalance in oxidative stress, impairment mucosal barrier. Although chlorogenic acid (CA) shows potential effectively alleviating symptoms UC, its clinical application is hindered by poor bioavailability, stability, rapid metabolism, quick excretion. This study utilized a one-step enzyme-catalyzed polymerization technique create nanoparticles (CA NPs), aiming improve bioavailability stability CA. CA NPs exhibited optimal nanosize (106.65 ± 4.12 nm) showed increased cellular uptake over time. Importantly, significantly prolonged retention time inflamed colonic tissues, enhancing accumulation providing targeted therapy for UC. Animal studies confirmed substantial benefits NPs, including reduced weight loss, lessened reduction colon length, lowered disease activity index (DAI) score DSS-induced UC mice. Moreover, stress levels inflammatory factors tissues mice, thus mitigating tissue damage restoring integrity In conclusion, our research proposes novel approach increase CA, offering promising avenue effective preventing
Язык: Английский
Процитировано
3
Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1073 - 1073
Опубликована: Авг. 16, 2024
Ulcerative colitis (UC) results in inflammation and ulceration of the colon rectum’s inner lining. The application herbal therapy UC is increasing worldwide. As natural macromolecular compounds, polysaccharides have a significant role treatment due to advantages better biodegradation, good biocompatibility, immunomodulatory activity, low reactogenicity. Therefore, polysaccharide drug formulation becoming potential candidate for treatment. In this review, we summarize etiology pathogenesis therapeutic effects on UC, such as regulating expression cytokines tight junction proteins modulating balance immune cells intestinal microbiota. Polysaccharides can also serve delivery carriers enhance targeting reduce side effects. This review provides theoretical basis applying plant prevention UC.
Язык: Английский
Процитировано
3
Advanced Therapeutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2025, Номер 673, С. 125375 - 125375
Опубликована: Фев. 16, 2025
Язык: Английский
Процитировано
0