Metal-organic
framework
(MOF)-based
drug
delivery
nanomaterials
for
cancer
therapy
has
attracted
increasing
attention
in
recent
years.
Here,
we
propose
an
situ
catalytic
hydroxyl
radical
generation
strategy
tumor
using
core-shell
zeolitic
imidazolate
framework-8
(ZIF-8)@Fe3O4
as
a
therapeutic
platform
to
enhance
Fenton
reaction-mediated
anti-tumor
treatment.
Carboxymethyl
cellulose
(CMC)
was
used
stabilizer
of
Fe3O4,
which
then
decorated
on
the
surface
ZIF-8
via
electrostatic
interaction
and
served
efficient
reaction
trigger.
Meanwhile,
pH-responsive
scaffold
acts
container
encapsulate
chemotherapeutic
doxorubicin
(DOX).
The
obtained
nanoparticles
(DOX-ZIF-8@Fe3O4/CMC,
designated
DZFC)
concomitantly
accelerates
DOX
release
generates
more
lysosomal
targeting
cells.
In
vitro
vivo
studies
verify
that
DZFC
trigger
GPX4-dependent
ferroptosis
activation
c-Jun
N-terminal
kinases
(JNK)
signaling
pathway
achieve
chemo/chemodynamic
synergistic
efficacy.
This
composite
nanoparticle
remarkably
suppresses
growth
with
minimized
systemic
toxicity,
opening
new
horizons
next
theragnostic
nanomedicines.
Green Chemistry,
Год журнала:
2023,
Номер
25(24), С. 10596 - 10610
Опубликована: Янв. 1, 2023
The
first
synthesis
of
Zirconium-based
MOF
PCN-222
with
defined
morphology
using
continuous
flow
chemistry
is
reported.
potential
for
biomedical
applications
explored
by
loading
a
thio-
N
-acetyl
galactosamine-PEG-sulfate
ligand.
Nano Letters,
Год журнала:
2024,
Номер
24(34), С. 10605 - 10613
Опубликована: Авг. 15, 2024
A
metal-organic
frameworks
(MOFs)-in-MOF
nanovehicle
(160
nm),
which
was
constructed
with
newly
prepared
ultrasmall
Cu(I)Cu(II)-BTC
MOFs
(UCMs,
2.95
nm)
loaded
doxorubicin
(DOX)
and
a
nuclear
localization
signal
(NLS)
peptide
as
multicores
(UCMDNs)
ZIF-8
the
shell
MOF,
proposed
to
cross
layers
of
biological
barriers
adaptive
size
evolution
capacity
for
achieving
efficient
nucleus-targeted
drug
delivery.
It
first
enhanced
tumor
tissue
penetration
through
its
larger
nanosize
effect.
Then
acidic
environment
made
degrade,
releasing
small-sized
UCMDNs
enter
into
cell
nucleus
under
guidance
NLS.
Furthermore,
due
distinct
surface
structural
characteristics
UCMs,
remained
stable
in
cytoplasm
collapsed
DOX-DNA
interaction
deliver
DOX
precisely.
showed
superior
performance
nucleus-directed
delivery
(delivery
efficiency
up
56.7%)
high
growth
inhibition
rate
(96.4%),
offering
promising
prospects
chemotherapy.
Molecular Systems Design & Engineering,
Год журнала:
2024,
Номер
9(11), С. 1085 - 1106
Опубликована: Янв. 1, 2024
Porous
nanostructures
exhibit
remarkable
nanoplatforms
for
payload
delivery
to
diseased
cells
with
high
loading
capacity,
favorable
release
profiles,
improved
hemocompatibility,
biocompatibility,
and
safe
clearance
after
biodegradation.
ACS Omega,
Год журнала:
2024,
Номер
9(26), С. 28937 - 28950
Опубликована: Июнь 15, 2024
We
have
developed
a
highly
efficient
technique
of
magnetically
controlled
swift
loading
and
release
doxorubicin
(DOX)
drug
using
magnetoelectric
nanogenerator
(MENG).
Core–shell
nanostructured
MENG
with
magnetostrictive
core
piezoelectric
shell
act
as
field-responsive
nanocarriers
possess
the
capability
field-triggered
in
cancerous
environment.
MENGs
generate
surface
electric
dipole
when
subjected
to
magnetic
field
due
strain-mediated
effect.
The
directional
field-assisted
modulation
electrical
provides
mechanism
create/break
ionic
bonds
DOX
molecules,
which
facilitates
attachment
on-demand
detachment
at
targeted
site.
drug-loading
was
minutely
analyzed
spectrophotometry
Raman
spectroscopy.
detailed
time-dependent
analysis
by
under
unidirectional
rotating
excitation
conducted
field-emission
scanning
electron
microscopy,
energy-dispersive
X-ray,
atomic
force
microscopic
measurements.
In
vitro,
experiments
validate
cytocompatibility
assisted
delivery
near
MCF-7
breast
cancer
cells,
results
significant
enhancement
cell
killing
efficiency.
A
state-of-the-art
experiment
performed
visualize
nanoscale
effect
off-axis
holography
Lorentz
conditions.
Coatings,
Год журнала:
2023,
Номер
13(7), С. 1273 - 1273
Опубликована: Июль 20, 2023
Extensive
research
has
been
conducted
on
ZrO2
nanostructures
due
to
their
favorable
biocompatibility,
low
toxicity,
and
promising
prospects
in
various
biomedical
applications.
They
can
be
used
as
drug
carriers,
facilitating
the
administration
of
therapeutic
substances
into
body
while
enhancing
effectiveness
safety.
This
is
achieved
by
regulating
timing,
location,
rate
at
which
drugs
are
released
within
body.
Several
factors
influence
loading
onto
nanostructures,
such
physicochemical
characteristics
drugs,
surface
properties
specific
methods
for
loading.
A
wide
range
may
loaded
including
anti-cancer
antibiotics,
anti-inflammatory
antifungal
anti-osteoporotic
etc.
The
release
kinetics
influenced
different
factors,
size
shape
pH
temperature
medium,
molecular
weight
being
released.
While
have
demonstrated
significant
potential
delivery
systems,
further
these
structures
essential
optimize
strategies.
Reviews in Inorganic Chemistry,
Год журнала:
2024,
Номер
44(4), С. 637 - 654
Опубликована: Июнь 27, 2024
Abstract
Metal-organic
frameworks
(MOFs)
represent
a
fusion
of
compelling
porous
structures,
alluring
physical
and
chemical
attributes,
extensive
possibilities
for
application.
The
inherent
capability
employing
these
organic
constituents
has
paved
the
path
construction
MOFs,
permitting
imaginative
pre-design
post-synthetic
adjustments
through
apt
reactions.
This
adaptability
not
only
enriches
structural
variety
MOFs
but
also
uncovers
pathways
customizing
their
characteristics
to
align
with
precise
application
needs.
In
this
context,
click
chemistry
emerged
as
potent
resilient
tool
in
creation
modification
diverse
functional
materials,
promising
MOF
structures.
These
architectures
undergo
postsynthetic
modifications
“click”
chemistry.
approach,
characterized
by
its
efficiency
selectivity,
proves
instrumental
tailoring
enhancing
properties
thereby
expanding
utility
across
spectrum
scientific
industrial
applications.
Herein,
we
illuminate
recent
structures
achieved
Our
exploration
delves
into
forefront
strategies
propelling
process,
dedicated
focus
on
complexities,
synthesis
methodologies,
prospective
applications
modified
architectures.
intention
is
actively
contribute
continuous
discourse
development
architectures,
encouraging
scientists
dedicate
expertise
efforts
towards
advancement
multifunctional
materials.
