Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

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A Comprehensive Review of Nanoparticles: From Classification to Application and Toxicity

Molecules, Год журнала: 2024, Номер 29(15), С. 3482 - 3482

Опубликована: Июль 25, 2024

Nanoparticles are structures that possess unique properties with high surface area-to-volume ratio. Their small size, up to 100 nm, and potential for modifications have enabled their use in a wide range of applications. Various factors influence the applications NPs, including synthesis method physical attributes such as size shape. Additionally, materials used NPs primary determinants application. Based on chosen material, generally classified into three categories: organic, inorganic, carbon-based. These categories include variety materials, proteins, polymers, metal ions, lipids derivatives, magnetic minerals, so on. Each material possesses activity application NPs. Consequently, certain typically particular areas because they higher efficiency along tenable toxicity. Therefore, classification base NP hold significant importance both research In this paper, we discuss these classifications, exemplify most major categorize them according preferred area This review provides an overall application,

Язык: Английский

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Herbal Theranostics: Controlled, Targeted Delivery and Imaging of Herbal Molecules

Nanotheranostics, Год журнала: 2024, Номер 8(3), С. 344 - 379

Опубликована: Янв. 1, 2024

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Язык: Английский

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Nanotechnology-empowered combination therapy for rheumatoid arthritis: principles, strategies, and challenges

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 22, 2024

Abstract Rheumatoid arthritis (RA) is an autoimmune disease with multifactorial etiology and intricate pathogenesis. In RA, repeated monotherapy frequently associated inadequate efficacy, drug resistance, severe side effects. Therefore, a shift has occurred in clinical practice toward combination therapy. However, conventional therapy encounters several hindrances, including low selectivity to arthritic joints, short half-lives, varying pharmacokinetics among coupled drugs. Emerging nanotechnology offers incomparable opportunity for developing advanced against RA. First, it allows co-delivering multiple drugs augmented physicochemical properties, targeted delivery capabilities, controlled release profiles. Second, enables therapeutic nanomaterials development, thereby expanding regimens include multifunctional nanomedicines. Lastly, facilitates the construction of all-in-one nanoplatforms assembled modalities, such as phototherapy, sonodynamic therapy, imaging. Thus, promising solution current bottleneck both RA treatment diagnosis. This review summarizes rationale, advantages, recent advances nano-empowered It also discusses safety considerations, drug–drug interactions, potential translation. Additionally, provides design tips outlook on future developments The objective this achieve comprehensive understanding mechanisms underlying unlock maximum nanotechnology, facilitating smooth transition research findings from laboratory practice.

Язык: Английский

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Recent Trends in Use of Plant-Derived Carbon Dot-Based Fluorescent Probes for Heavy Metal Ion Detection and Their Biological Applications

Trends in Environmental Analytical Chemistry, Год журнала: 2025, Номер unknown, С. e00259 - e00259

Опубликована: Фев. 1, 2025

Язык: Английский

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Nitrogen-doped carbon quantum dots for fluorescence sensing, anti-counterfeiting and logic gate operations

New Journal of Chemistry, Год журнала: 2023, Номер 48(1), С. 155 - 161

Опубликована: Ноя. 21, 2023

Fluorescent nitrogen-doped CQDs were successfully fabricated for application in fluorescence sensing, anti-counterfeiting, and logic gate operations by a solvothermal method using ammonia, citric acid phloroglucinol as precursors.

Язык: Английский

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Recent advances in carbon dots-based chromatographic separation materials

Chinese Journal of Chromatography, Год журнала: 2023, Номер 41(10), С. 825 - 834

Опубликована: Окт. 1, 2023

Chromatographic column is the core of chromatographic separation, and separation material considered soul column. The type characteristics directly determine mode performance columns. development preparation materials with novel structures good an ongoing hotspot in chromatography research. Given rapid developments nanoscience technology, nanomaterials unique surface functional groups large specific areas have attracted extensive attention great interest from researchers field science. Carbon dots (CDs), a new zero-dimensional fluorescent carbon nanomaterials, been widely used bioimaging, light-emitting diodes, sensing, catalysis, drug delivery, other applications since they were first reported 2004. These present several advantages over types materials, including simple process, low toxicity, easy functionalization, excellent biocompatibility, photobleaching resistance. In addition, compared traditional such as graphene nanotubes, CDs abundant groups, nanoscale sizes, moderate adsorption properties. Hence, when CDs-based are applied stationary phase for chromatography, can provide rich reaction sites ensure uniformity packing process. use effectively avoid peak-tailing phenomenon caused by strong interaction π-conjugated systems some analytes improve efficiency As such, these show application prospects separation. this review, history, classification, synthesis strategies briefly described. We then focus on systematically reviewing recent advances high-performance liquid (including hydrophilic interaction, reversed-phase, mixed-mode, chiral chromatography), gas capillary electrochromatography, special emphasis methods various phases. Finally, future research efforts also analyzed discussed. This review guidance rational design materials.

Язык: Английский

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MiR675-5p Acts on HIF-1α to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma

Theranostics, Год журнала: 2016, Номер 6(8), С. 1105 - 1118

Опубликована: Янв. 1, 2016

Modern medicine relies on a small number of key biologics, which can be found in nature but require further characterization and purification before they used.Since the herbal remedy is given through dated ineffective method drug administration, its effectiveness diminished.The novel form delivery has potential to increase substances while decreasing their side effects.This main idea behind utilising different ways treatments.Several benefits arise from formulations compounds as compared conventional counterparts.These include enhanced penetrating ability into tissues, constant effective doses, resistance physical chemical degradation.Controlled targeted that components allow for more traditional dosing simultaneously increasing efficacy.Enhancing biodistribution target site accumulation systemically administered medicines goal nanomedicine formulations.The field nanotheranostics made significant advancements development by combining diagnostic therapeutic functions single nanoscale platform.It critically important create theranostic nanoplatform derived plants intrinsically "all-in-one" molecules.In addition examining mechanistic approach nanoparticle synthesis, this review highlights effects phytochemical systems.Furthermore, we have evaluated scope future field, discussed several nanoparticles been developed recently imaging, provided experimental evidence supports usage.

Язык: Английский

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Exploring the Therapeutic Potential of Ammodaucus leucotrichus Seed Extracts: A Multi-Faceted Analysis of Phytochemical Composition, Anti-Inflammatory Efficacy, Predictive Anti-Arthritic Properties, and Molecular Docking Insights

Pharmaceuticals, Год журнала: 2024, Номер 17(3), С. 385 - 385

Опубликована: Март 18, 2024

Ammodaucus leucotrichus exhibits promising pharmacological activity, hinting at anti-inflammatory and anti-arthritic effects. This study investigated seed extracts from using methanol n-hexane, focusing on properties. The extract outperformed the n-hexane diclofenac, a reference drug, in trypsin inhibition (85% vs. 30% 64.67% 125 μg/mL). For inhibition, IC50 values were 82.97 μg/mL (methanol), 202.70 (n-hexane), 97.04 (diclofenac). Additionally, surpassed diclofenac BSA (bovine serum albumin) denaturation (90.4% 22.0% 51.4% 62.5 14.30 5408 42.30 Gas chromatography-mass spectrometry (GC-MS) revealed 59 58 secondary metabolites extracts, respectively. higher therapeutic activity of was attributed to hydroxyacetic acid hydrazide, absent extract. In silico docking studies identified 28 compounds with negative binding energies, indicating potential inhibition. 2-hydroxyacetohydrazide displayed superior inhibitory effects compared diclofenac. Further mechanistic are crucial validate as drug candidate for rheumatoid arthritis treatment.

Язык: Английский

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B, S, N co-doped carbon dots-based highly sensitive and rapid nanoprobe for monitoring of pepsin activity in human saliva and its cell imaging

Journal of Photochemistry and Photobiology A Chemistry, Год журнала: 2025, Номер unknown, С. 116349 - 116349

Опубликована: Фев. 1, 2025

Язык: Английский

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