Application of carbon-based nanomaterials in Alzheimer's disease
Materials Horizons,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Alzheimer's
disease
(AD)
is
a
chronic,
progressive
neurodegenerative
disorder
marked
by
permanent
impairment
of
brain
function
across
the
whole
brain.
This
condition
results
in
deterioration
cognitive
patients
and
frequently
associated
with
psychological
symptoms
such
as
agitation
anxiety,
imposing
significant
burden
on
both
their
families.
Nanomaterials
possess
numerous
distinctive
physical
chemical
features
that
render
them
extensively
utilized.
In
biomedical
domain,
nanomaterials
can
be
utilized
for
prevention
therapy,
including
medication
delivery
systems,
biosensors,
tissue
engineering.
article
explores
etiology
potential
molecular
processes
AD,
well
application
carbon-based
diagnosis
treatment
AD.
Some
are
carbon
quantum
dots,
nanotubes,
graphene,
among
others.
These
materials
physicochemical
highly
promising
applications
biosensing,
drug
delivery,
neuroprotection,
photothermal
treatment.
addition,
this
review
explored
various
therapeutic
approaches
AD
terms
reducing
inflammation,
preventing
oxidative
damage,
inhibiting
Aβ
aggregation.
The
advent
nanotechnology
has
facilitated
development
novel
disease.
strategies
provide
early
diagnosis,
effective
intervention
neuroprotection
Язык: Английский
Dual‐Carbon Dots Composite: A Multifunctional Photo‐Propelled Nanomotor Against Alzheimer's β‐Amyloid
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 11, 2024
Abstract
The
abnormal
accumulation
of
β
‐amyloid
protein
(A
)
is
considered
as
the
main
pathological
hallmark
Alzheimer's
disease
(AD).
design
potent
multifunctional
theranostic
agents
targeting
A
one
effective
strategies
for
AD
prevention
and
treatment.
Nanomotors
intelligent,
advanced,
nanoplatforms
can
perform
many
complex
tasks,
but
their
application
in
theranostics
rare.
Herein,
sub‐10nm
dual‐carbon
dots
composites
(ERCD)
with
photo‐propelled
nanomotor
behavior
are
fabricated
by
conjugating
near‐infrared
(NIR)
carbon
(RCD)
thermogenic
photodynamic
capability
previously
reported
epigallocatechin
gallate‐derived
carbonized
polymer
(ECD).
ERCD‐1
(ECD:RCD
=
1:2.5)
showed
inhibitory
similar
to
ECD
absence
NIR
light,
exhibited
photooxygenation
activity
powered
“self‐thermophoretic
force”
under
irradiation,
significantly
enhancing
inhibition,
disaggregation,
capabilities.
suppressed
fibrillization
rapidly
disaggregated
mature
fibrils
at
very
low
concentrations
(0.5
µg
mL
−1
).
Moreover,
NIR‐activated
imaged
plaques
vivo
prolonged
nematode
lifespan
6
d
2
.
As
a
proof‐of‐concept,
this
work
opened
new
avenue
nanomotors
theranostics.
Язык: Английский
Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease
Aggregate,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
ABSTRACT
Alzheimer's
disease
(AD)
is
one
of
the
most
prevalent
forms
neurodegenerative
disease.
Although
some
controversy
exists,
β‐amyloid
peptide
(Aβ)
recognized
to
play
an
essential
role
in
pathophysiology
AD.
The
Aβ
species
are
known
exist
various
forms,
including
soluble
monomers,
oligomers,
and
insoluble
aggregates.
Despite
extensive
efforts
regulate
aggregation,
no
successful
medications
have
been
developed
date.
Among
strategies
for
AD
treatment,
phototherapy,
photodynamic
therapy
(PDT),
photothermal
(PTT),
photopharmacology,
photobiomodulation
(PBM)
attracted
increased
attention
because
spatiotemporal
controllability.
Representative
examples
PDT,
PTT,
PBM
discussed
terms
inhibitory
mechanism,
unique
properties
materials,
design
phototherapy
modulators.
major
challenges
against
addressed
promising
prospects
proposed.
It
concluded
that
noninvasive
light‐assisted
approaches
will
become
a
strategy
intensifying
modulation
aggregation
or
promoting
clearance
thus
facilitating
treatment.
Язык: Английский
Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 16, 2025
Abstract
The
rapidly
advancing
field
of
theranostics
aims
to
integrate
therapeutic
and
diagnostic
functionalities
into
a
single
platform
for
precision
medicine,
enabling
the
simultaneous
treatment
monitoring
diseases.
Photo‐energy
conversion‐based
nanomaterials
have
emerged
as
versatile
that
utilizes
unique
properties
light
activate
with
high
spatial
temporal
precision.
This
review
provides
comprehensive
overview
recent
developments
in
photo‐energy
conversion
using
nanomaterials,
highlighting
their
applications
disease
theranostics.
discussion
begins
by
exploring
fundamental
principles
including
types
materials
used
various
light‐triggered
mechanisms,
such
photoluminescence,
photothermal,
photoelectric,
photoacoustic,
photo‐triggered
SERS,
photodynamic
processes.
Following
this,
delves
broad
spectrum
emphasizing
role
diagnosis
major
diseases,
cancer,
neurodegenerative
disorders,
retinal
degeneration,
osteoarthritis.
Finally,
challenges
opportunities
technologies
are
discussed,
aiming
advance
personalized
medicine.
Язык: Английский
Deep eutectic solvent-assisted preparation of resveratrol-based carbon dots with high biocompatibility for in situ screening inhibitors on amyloid protein aggregation and scavenging reactive oxygen species
Sensors and Actuators B Chemical,
Год журнала:
2023,
Номер
400, С. 134901 - 134901
Опубликована: Ноя. 3, 2023
Язык: Английский
Multifunctional selenium-doped carbon dots for modulating Alzheimer's disease related toxic ions, inhibiting amyloid aggregation and scavenging reactive oxygen species
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 139333 - 139333
Опубликована: Дек. 1, 2024
Язык: Английский
An in situ-activated and chemi-excited photooxygenation system based on G-poly(thioacetal) for Aβ1-42 aggregates
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(42), С. 10850 - 10860
Опубликована: Янв. 1, 2024
BD-6-QM/NPs
are
chemically
activated
by
H
2
O
to
produce
1
,
inhibit
Aβ
1–42
aggregation,
promote
BV2
phagocytosis
of
and
alleviate
-induced
neurotoxicity.
Язык: Английский
Application of carbon dots-based nanomaterials in amyloid aggregation disease
Carbon,
Год журнала:
2024,
Номер
unknown, С. 119971 - 119971
Опубликована: Дек. 1, 2024
Язык: Английский
Multifunctional carbonized polymer dots: Synthesis and applications in retarding protein amyloid aggregation, capturing free radicals and cell imaging
Journal of Molecular Structure,
Год журнала:
2024,
Номер
1319, С. 139419 - 139419
Опубликована: Июль 26, 2024
Язык: Английский
To explore the protective mechanism of promethazine against hippocampal neuron injury based on network pharmacology and experimental verification
Medicine,
Год журнала:
2024,
Номер
103(49), С. e40550 - e40550
Опубликована: Дек. 6, 2024
This
study
aims
to
investigate
the
effect
of
promethazine
(PMZ)
on
hippocampal
neuronal
injury
through
network
pharmacology
and
in
vivo
experiments.
Network
pharmacology:
The
intersection
genes
PMZ
Alzheimer
Disease
(AD)
were
obtained,
core
AD
screened.
enriched
by
Gene
Ontology
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analyses.
In
vitro
experiment,
mouse
neurons
(HT22)
divided
into
control,
glutamate
(GLU)
model,
GLU
+
treatment
groups.
control
group
was
given
a
complete
culture
medium,
model
for
24
hours,
pretreatment
3
then
administered
hours.
Cell
viability
determined,
cell
morphology
observed
microscopy,
reactive
oxygen
species
levels
glutathione
content
detected,
protein
expression
P53,
PTGS2,
SLC7A11,
GPX4
detected
western
blotting.
A
total
317
targets,
1934
genes,
125
18
including
P53
PTGS2.
analysis
showed
that
mainly
related
proliferation,
inflammation,
hypoxia,
synaptic
structure,
plasma
membrane,
oxidoreductase
activity.
results
neuroactive
ligand-receptor
interaction,
senescence,
cancer
pathway,
PI3K-AKT
signal
neurodegeneration,
HIF-1
pathway.
experiments:
improved
GLU-induced
decrease
morphological
changes
neurons.
inhibited
increased
injured
Up-regulated
SLC7A11
expression,
regulates
SLC7A11-GPX4
antioxidant
system
protect
from
oxidative
stress
injury.
Язык: Английский