Legumain-Triggered Macrocyclization of Radiofluorinated Tracer for Enhanced PET Imaging DOI
Xiaoqing Gao,

Qianhui Wang,

Xiaofeng Yang

и другие.

Bioconjugate Chemistry, Год журнала: 2024, Номер 35(5), С. 665 - 673

Опубликована: Апрель 10, 2024

Enhancing the accumulation and retention of small-molecule probes in tumors is an important way to achieve accurate cancer diagnosis therapy. Enzyme-stimulated macrocyclization small molecules possesses great potential for enhanced positron emission tomography (PET) imaging tumors. Herein, we reported

Язык: Английский

Cathepsin B-Activated PET Tracer for In Vivo Tumor Imaging DOI
Huirong Li,

Beibei Liang,

Xiaoqing Gao

и другие.

Molecular Pharmaceutics, Год журнала: 2024, Номер 21(3), С. 1382 - 1389

Опубликована: Фев. 19, 2024

Cathepsin B, a lysosomal protease, is considered as crucial biomarker for tumor diagnosis and treatment it overexpressed in numerous cancers. A stimulus-responsive SF scaffold has been reported to detect the activity of variety tumor-associated enzymes. In this work, small-molecule PET tracer ([68Ga]NOTA-SF-CV) was developed by combining an with cathepsin B-specific recognition substrate Cit-Val. Upon activation [68Ga]NOTA-SF-CV could form cyclization product reduction environment, resulting reduced hydrophilicity. This unique property effectively prevent exocytosis B-overexpressing cells, leading prolonged retention amplified imaging signal. Moreover, had great targeting specificity B. vivo microPET results showed that able visualize expression level B various tumors. Hence, may be served potential diagnosing B-related diseases.

Язык: Английский

Процитировано

3
Assembling a new generation of radiopharmaceuticals with supramolecular theranostics DOI
Guillermo Moreno‐Alcántar, Marike Drexler, Angela Casini

и другие.

Nature Reviews Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

Язык: Английский

Процитировано

3
Lysosome-targeting and legumain-triggered 68Ga-labeled probe for enhanced tumor PET imaging DOI
Di Hua,

Hongjie Xi,

Xie Quan

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 703, С. 149646 - 149646

Опубликована: Фев. 7, 2024

Язык: Английский

Процитировано

1
Towards imaging the immune state of cancer by PET: Targeting legumain with 11C-labeled P1-Asn peptidomimetics carrying a cyano-warhead DOI Creative Commons

Severin Lustenberger,

Claudia A. Castro Jaramillo,

Lena A Bärtschi

и другие.

Nuclear Medicine and Biology, Год журнала: 2024, Номер 138-139, С. 108951 - 108951

Опубликована: Сен. 13, 2024

Язык: Английский

Процитировано

1
Legumain-Triggered Macrocyclization of Radiofluorinated Tracer for Enhanced PET Imaging DOI
Xiaoqing Gao,

Qianhui Wang,

Xiaofeng Yang

и другие.

Bioconjugate Chemistry, Год журнала: 2024, Номер 35(5), С. 665 - 673

Опубликована: Апрель 10, 2024

Enhancing the accumulation and retention of small-molecule probes in tumors is an important way to achieve accurate cancer diagnosis therapy. Enzyme-stimulated macrocyclization small molecules possesses great potential for enhanced positron emission tomography (PET) imaging tumors. Herein, we reported

Язык: Английский

Процитировано

0