Angewandte Chemie,
Год журнала:
2024,
Номер
136(39)
Опубликована: Июль 9, 2024
Abstract
Since
the
discovery
of
first
peroxidase
nanozyme
(Fe
3
O
4
),
numerous
nanomaterials
have
been
reported
to
exhibit
intrinsic
enzyme‐like
activity
toward
inorganic
oxygen
species,
such
as
H
2
,
oxygen,
and
−
.
However,
exploration
nanozymes
targeting
organic
compounds
holds
transformative
potential
in
realm
industrial
synthesis.
This
review
provides
a
comprehensive
overview
diverse
types
that
catalyze
reactions
involving
substrates
discusses
their
catalytic
mechanisms,
structure‐activity
relationships,
methodological
paradigms
for
discovering
new
nanozymes.
Additionally,
we
propose
forward‐looking
perspective
on
designing
formulations
mimic
subcellular
organelles,
chloroplasts,
termed
“nano‐organelles”.
Finally,
analyze
challenges
encountered
synthesis,
characterization,
nano‐organelle
construction
applications
while
suggesting
directions
overcome
these
obstacles
enhance
research
future.
Through
this
review,
our
goal
is
inspire
further
efforts
advancements
field
nanozymes,
fostering
insights
opportunities
chemical
Abstract
Background
Pancreatic
cancer
(PCA)
is
an
extremely
aggressive
malignant
with
increasing
incidence
and
a
low
five‐year
survival
rate.
The
main
reason
for
this
high
mortality
that
most
patients
are
diagnosed
PCA
at
advanced
stage,
missing
early
treatment
options
opportunities.
As
important
nutrients
of
the
human
body,
trace
elements
play
role
in
maintaining
normal
physiological
functions.
Moreover,
closely
related
to
many
diseases,
including
PCA.
Review
This
review
systematically
summarizes
latest
research
progress
on
selenium,
copper,
arsenic,
manganese
PCA,
elucidates
their
application
provides
new
reference
prevention,
diagnosis
Conclusion
Trace
such
as
arsenic
playing
risk,
pathogenesis,
Meanwhile,
they
have
certain
inhibitory
effect
mechanism
mainly
includes:
promoting
ferroptosis,
inducing
apoptosis,
inhibiting
metastasis,
excessive
proliferation.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 9, 2024
Lung
cancer
has
high
metastasis
and
drug
resistance.
The
prognosis
of
lung
patients
is
poor
the
patients’
survival
chances
are
easily
neglected.
Ferroptosis
a
programmed
cell
death
proposed
in
2012,
which
differs
from
apoptosis,
necrosis
autophagy.
novel
type
regulated
driven
by
iron-dependent
lipid
peroxidation
subsequent
plasma
membrane
ruptures.
It
broad
prospects
field
tumor
disease
treatment.
At
present,
multiple
studies
have
shown
that
biological
compounds
can
induce
ferroptosis
cells,
exhibits
significant
anti-cancer
effects,
they
advantages
safety,
minimal
side
less
possibility
to
In
this
review,
we
summarize
used
for
treatment
focusing
on
its
mechanism.
addition,
systematically
review
current
research
status
combining
nanotechnology
with
treatment,
shed
new
light
targeting
pathways
applying
compounds-based
therapies.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5273 - 5295
Опубликована: Июнь 1, 2024
Purpose:
Reducing
the
first-pass
hepatic
effect
via
intestinal
lymphatic
transport
is
an
effective
way
to
increase
oral
absorption
of
drugs.
2-Monoacylglycerol
(2-MAG)
as
a
primary
digestive
product
dietary
lipids
triglyceride,
can
be
assembled
in
chylomicrons
and
then
transported
from
intestine
into
system.
Herein,
we
propose
biomimetic
strategy
report
2-MAG
mimetic
nanocarrier
target
system
lipid
pathway
improve
bioavailability.
Methods:
The
liposomes
were
designed
by
covalently
bonding
serinol
(SER)
on
surface
named
SER-LPs
simulate
structure
2-MAG.
Dihydroartemisinin
(DHA)
was
chosen
model
drug
because
its
disadvantages
such
poor
solubility
high
effect.
endocytosis
exocytosis
mechanisms
investigated
Caco-2
cells
cell
monolayers.
capacity
evaluated
ex
vivo
biodistribution
pharmacokinetic
experiments.
Results:
DHA
loaded
(SER-LPs-DHA)
had
particle
size
70
nm
desirable
entrapment
efficiency
93%.
showed
sustained
release
for
simulated
gastrointestinal
environment.
In
vitro
studies
demonstrated
that
cellular
uptake
primarily
relied
caveolae-
rather
than
clathrin-mediated
preferred
integrate
chylomicron
assembly
process
through
endoplasmic
reticulum/Golgi
apparatus
route.
After
administration,
efficiently
promoted
accumulation
mesenteric
nodes.
bioavailability
10.40-fold
1.17-fold
larger
free
unmodified
at
same
dose,
respectively.
Conclusion:
improved
efficient
transport.
These
findings
current
study
provide
good
alternative
delivery
drugs
with
metabolism.
Keywords:
transport,
liposomes,
metabolism,
delivery,
dihydroartemisinin
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 16, 2024
Since
the
discovery
of
Fe3O4
nanoparticles
with
enzyme-like
activity
in
2007,
nanozymes
have
emerged
as
a
promising
class
catalysts,
offering
advantages
such
high
catalytic
efficiency,
low
cost,
mild
reaction
conditions,
and
excellent
stability.
These
properties
make
highly
suitable
for
large-scale
production.
In
recent
years,
convergence
nanomedicine
nanocatalysis
has
highlighted
potential
diagnostic
therapeutic
applications,
particularly
tumor
therapy.
Despite
these
advancements,
clinical
translation
remains
hindered
by
lack
designs
tailored
to
specific
characteristics,
limiting
their
effectiveness
targeted
This
review
addresses
mechanisms
which
induce
cell
death
various
types
emphasizes
key
design
considerations
needed
enhance
potential.
By
identifying
challenges
opportunities
field,
this
study
aims
provide
foundation
future
nanozyme
development,
ultimately
contributing
more
precise
effective
cancer
treatments.
