Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2071 - 2071
Опубликована: Фев. 8, 2024
Nanoencapsulation
has
become
a
recent
advancement
in
drug
delivery,
enhancing
stability,
bioavailability,
and
enabling
controlled,
targeted
substance
delivery
to
specific
cells
or
tissues.
However,
traditional
nanoparticle
faces
challenges
such
as
short
circulation
time
immune
recognition.
To
tackle
these
issues,
cell
membrane-coated
nanoparticles
have
been
suggested
practical
alternative.
The
production
process
involves
three
main
stages:
lysis
membrane
fragmentation,
isolation,
coating.
Cell
membranes
are
typically
fragmented
using
hypotonic
with
homogenization
sonication.
Subsequent
fragments
isolated
through
multiple
centrifugation
steps.
Coating
can
be
achieved
extrusion,
sonication,
combination
of
both
methods.
Notably,
this
analysis
reveals
the
absence
universally
applicable
method
for
coating,
stages
differ
significantly
their
procedures.
This
review
explores
current
developments
approaches
nanoparticles,
highlighting
potential
an
effective
alternative
various
therapeutic
applications.
Язык: Английский
Engineered Cell Membrane-Camouflaged Nanomaterials for Biomedical Applications
Nanomaterials,
Год журнала:
2024,
Номер
14(5), С. 413 - 413
Опубликована: Фев. 23, 2024
Recent
strides
in
nanomaterials
science
have
paved
the
way
for
creation
of
reliable,
effective,
highly
accurate,
and
user-friendly
biomedical
systems.
Pioneering
integration
natural
cell
membranes
into
sophisticated
nanocarrier
architectures,
membrane
camouflage
has
emerged
as
a
transformative
approach
regulated
drug
delivery,
offering
benefits
minimal
immunogenicity
coupled
with
active
targeting
capabilities.
Nevertheless,
utility
such
is
curtailed
by
challenges
like
suboptimal
precision
lackluster
therapeutic
efficacy.
Tailored
engineering
stands
at
forefront
biomedicine,
equipping
nanoplatforms
capacity
to
conduct
more
complex
operations.
This
review
commences
an
examination
prevailing
methodologies
engineering,
spotlighting
strategies
direct
chemical
modification,
lipid
insertion,
hybridization,
metabolic
glycan
labeling,
genetic
engineering.
Following
this,
evaluation
unique
attributes
various
presented,
delivering
in-depth
scrutiny
substantial
advancements
applications
driven
cutting-edge
engineered
camouflage.
The
discourse
culminates
recapitulating
salient
influence
within
nanomaterial
prognosticates
its
seminal
role
healthcare
technologies.
It
envisaged
that
insights
offered
herein
will
catalyze
novel
avenues
innovation
refinement
camouflaged
nanotechnologies.
Язык: Английский
Nanomaterials in gastric cancer: pioneering precision medicine for diagnosis, therapy, and prevention
Medical Oncology,
Год журнала:
2025,
Номер
42(4)
Опубликована: Март 6, 2025
Язык: Английский
Development of target-based cell membrane affinity ultrafiltration technology for a simplified approach to discovering potential bioactive compounds in natural products
Analytical and Bioanalytical Chemistry,
Год журнала:
2024,
Номер
416(7), С. 1647 - 1655
Опубликована: Фев. 2, 2024
Язык: Английский
Construction of biomimetic camouflaged neutrophil membrane nanoparticles for precise delivery and augmented glioma cancer treatment
Process Biochemistry,
Год журнала:
2024,
Номер
145, С. 229 - 242
Опубликована: Июнь 18, 2024
Язык: Английский
Microfluidics‐Driven Manufacturing and Multiscale Analytical Characterization of Nanoparticle‐Vesicle Hybrids
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Дек. 25, 2024
Coating
synthetic
nanoparticles
(NPs)
with
lipid
membranes
is
a
promising
approach
to
enhance
the
performance
of
nanomaterials
in
various
biological
applications,
including
therapeutic
delivery
target
organs.
Current
methods
for
achieving
this
coating
often
rely
on
bulk
approaches
which
can
result
low
efficiency
and
poor
reproducibility.
Continuous
processes
coupled
quality
control
represent
an
attractive
strategy
manufacture
products
consistent
attributes
high
yields.
Here,
concept
implemented
by
developing
acoustic
microfluidic
device
together
analytical
platform
prepare
nanoparticle-vesicle
hybrids
quantitatively
characterize
nanoparticle
coverage
using
fluorescence-based
techniques
at
different
levels
resolution.
With
polymethyl
methacrylate
(PMMA)
are
successfully
coated
liposomes
extracellular
vesicles
(EVs),
encapsulation
70%.
Moreover,
enables
identification
design
rules
tuning
operational
parameters
material
properties,
buffer
composition,
nanoparticle/vesicle
ratio,
vesicle
rigidity.
Язык: Английский
Chemical conjugation innovations for protein nanoparticles
Trends in Chemistry,
Год журнала:
2024,
Номер
6(8), С. 470 - 486
Опубликована: Июль 4, 2024
Язык: Английский
Research trends in functionalized Fe3O4 composites based on affinity recognition systems for targeted extraction of natural products
Journal of Chromatography A,
Год журнала:
2024,
Номер
1730, С. 465145 - 465145
Опубликована: Июль 8, 2024
Язык: Английский
Immobilized Protein Strategies Based on Cell Membrane Chromatography and its Application in Discovering Active and Toxic Substances in Traditional Chinese Medicine
Pharmacological Research,
Год журнала:
2024,
Номер
210, С. 107492 - 107492
Опубликована: Ноя. 2, 2024
Traditional
Chinese
medicine
(TCM)
contributes
significantly
to
human
health.
Owing
the
complexity
of
ingredients
in
TCM,
it
is
necessary
conduct
basic
research
on
effective
substances
and
identify
toxic
control
safety
medication.
Cell
membrane
chromatography
(CMC)
an
important
method
for
identifying
target
components
complex
systems.
The
cell
stationary
phase
(CMSP)
core
component
key
factor
determining
effectiveness
CMC.
This
review
summarizes
development
CMSP
with
different
protein
immobilization
strategies
application
CMC
discovery
active
aim
providing
means
quality
TCM.
Язык: Английский
Bioorthogonal Synthesis of Biomimetic Nanoparticles for Screening Chemical Hazards in Food Samples
Analytical Chemistry,
Год журнала:
2024,
Номер
97(1), С. 247 - 254
Опубликована: Дек. 30, 2024
The
ability
to
identify
unknown
risks
is
the
key
improving
level
of
food
safety.
However,
conventional
nontargeted
screening
methods
for
new
contaminant
identification
and
risk
assessment
remain
difficult
work.
Herein,
a
toxic-oriented
platform
based
on
high-expression
epidermal
growth
factor
receptor
HEK293
cell
membrane-coated
magnetic
nanoparticles
(EGFR/MNPs)
was
first
used
discovery
contaminants
from
samples.
EGFR
served
as
bait
bind
compounds,
considering
that
abnormal
activation
related
incidence
numerous
chronic
inflammatory
diseases.
membranes
were
specifically
covalently
immobilized
carriers
through
metabolic
glycoengineering
strain-promoted
alkyne–azide
cycloaddition
(SPAAC)
ensure
stability
bioactivity
EGFR/MNPs.
synthesized
EGFR/MNPs
possessed
an
excellent
loading
amount
screen
potential
substances
thermally
processed
food.
Finally,
two
harman
norharman,
rapidly
identified.
toxicological
experiments
confirmed
screened
compounds
could
promote
phosphorylation
further
activate
downstream
signaling
pathways,
thereby
inducing
cellular
oxidative
damage.
proposed
method
provided
identifying
Язык: Английский