ACS Nano,
Год журнала:
2024,
Номер
18(36), С. 24605 - 24616
Опубликована: Авг. 26, 2024
Sweat
analysis
has
advanced
from
diagnosing
cystic
fibrosis
and
testing
for
illicit
drugs
to
noninvasive
monitoring
of
health
biomarkers.
This
article
introduces
the
rapid
development
wearable
flexible
sweat
sensors,
highlighting
key
milestones
various
sensing
strategies
real-time
analytes.
We
discuss
challenges
such
as
developing
high-performance
nanomaterial-based
biosensors,
ensuring
continuous
production
sampling,
achieving
high
sweat/blood
correlation,
biocompatibility.
The
potential
machine
learning
enhance
these
sensors
personalized
healthcare
is
presented,
enabling
tracking
prediction
physiological
changes
disease
onset.
Leveraging
advancements
in
electronics,
nanomaterials,
biosensing,
data
analytics,
biosensors
promise
revolutionize
management,
prevention,
prediction,
promoting
healthier
lifestyles
transforming
medical
practices
globally.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
This
paper
reviews
the
latest
research
progress
of
surface-enhanced
Raman
spectroscopy
(SERS)
microfluidic
chips
in
field
biosensing.
Due
to
its
single-molecule
sensitivity,
selectivity,
minimal
or
no
preprocessing,
and
immediacy,
SERS
is
considered
a
promising
biosensing
technology.
However,
nondirectional
interactions
between
biological
samples
substrate,
as
well
fluctuations
sample
environment
temperature
during
signal
acquisition,
can
affect
stability
reproducibility
signals.
Integrating
with
not
only
leverages
continuous
flow,
high
reaction
efficiency,
throughput,
multifunctionality
address
challenges
applications
but
also
expands
scope
technology
by
providing
novel
on-chip
optical
detection
method.
The
combination
enables
complementary
advantages
both
technologies
offers
highly
"combined
technology"
for
starts
introducing
enhancement
mechanisms
presents
labeled
label-free
strategies.
Based
on
differences
substrate
properties,
we
broadly
categorize
into
colloidal
nanoparticle-based
fixed
substrate-based
chips.
Finally,
review
targets
such
nucleic
acids,
proteins,
small
biomolecules,
live
cells.
In
conclusion
outlook
section,
summarize
faced
propose
feasible
solutions.
To
better
leverage
role
biosensing,
present
an
future
development
this
combined
Review
Application
of
Wearable
Devices
in
Diabetes
Management
Zijing
Du
1,2,†,
Feifan
Zhang
1,†,
Yifei
Ge
1,
Yijiang
Liu
3,
Honghua
Yu
2,
Yong
Wang
4,
Rinkoo
Dalan
1,5,
and
Xiaotao
Shen
1,3,*
1
Lee
Kong
Chian
School
Medicine,
Nanyang
Technological
University,
Singapore,
636921,
Singapore
2
Guangdong
Eye
Institute,
Department
Ophthalmology,
Provincial
People’s
Hospital
(Guangdong
Academy
Medical
Sciences),
Southern
Guangzhou,
510080,
China
3
Chemistry,
Chemical
Engineering
Biotechnology,
639798,
4
College
Computing
Data
Science,
637616,
5
Endocrinology,
Tan
Tock
Seng
Hospital,
308433,
*
Correspondence:
[email protected]
†
These
authors
contributed
equally
to
this
work.
Received:
17
December
2024;
Revised:
20
January
2025;
Accepted:
12
February
Published:
19
2025
Abstract:
mellitus
poses
a
significant
global
health
challenge,
impacting
hundreds
millions
worldwide.
Effective
management
prevention
complications
rely
on
dynamic,
real-time
glucose
monitoring.
This
review
provides
comprehensive
overview
the
rapidly
evolving
landscape
wearable
technologies
for
monitoring
diabetes
care,
with
focus
cutting-edge
advancements
their
integration
artificial
intelligence
(AI)
multi-omics
data.
We
explore
diverse
approaches,
including
continuous
monitors
(CGMs)
smartwatches,
highlighting
contributions
tracking
physical
activity,
food
intake,
medication
adherence,
direct
measurements.
Our
emphasis
is
placed
role
AI
systems
enabling
predictive
analytics
personalized
as
well
data
insights—spanning
genomics,
proteomics,
gut
microbiome
analyses—to
enhance
understanding
individual
metabolism.
Given
challenges
existing
methods,
such
invasiveness,
accuracy,
accessibility,
we
discuss
future
directions,
potential
smart
glasses,
advanced
models,
seamless
integration,
revolutionize
management.
offers
valuable
insights
into
how
technologies,
AI,
multi-source
analysis
are
shaping
precision
care.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 19, 2025
With
the
advantages
of
miniaturization,
simple
device
structure,
and
fast
response,
organic
electrochemical
transistor
(OECT)
has
become
an
emerging
platform
for
developing
wearable
enzyme
sensors
real-time
health
monitoring.
The
floating
gate
(FG)
OECT
employs
a
distinct
signal
acquisition
amplification
mitigating
effects
non-specific
physical
adsorption
during
sensing
process
preventing
contamination
electrolyte
solution
by
side
reaction
products.
current
work
reports
feasible
sensor
using
poly(benzimidazobenzophenanthroline)
(BBL)-Nafion-enzyme-Nafion
stacking
structure
as
layer
FG
OECT.
Based
on
experimental
results,
BBL
film
with
area
3.14
mm2
thickness
175
nm
can
generate
open
circuit
potential
199.61
mV
in
10−
1
M
hydrogen
peroxide
compared
blank
control.
Then,
is
integrated
flexible
microfluidic
systems
on-skin
detection
glucose,
lactate,
uric
acid
sensitivities
92.47,
152.15,
74.27
µA·dec−
1,
respectively.
This
OECT-based
will
new
windows
multiplexed
sweat
metabolites.
Nanomaterials,
Год журнала:
2023,
Номер
13(22), С. 2968 - 2968
Опубликована: Ноя. 17, 2023
Surface-enhanced
Raman
scattering
(SERS)
is
a
cutting-edge
technique
for
highly
sensitive
analysis
of
chemicals
and
molecules.
Traditional
SERS-active
nanostructures
are
constructed
on
rigid
substrates
where
the
nanogaps
providing
hot-spots
signals
fixed,
sample
loading
unsatisfactory
due
to
unconformable
attachment
irregular
surfaces.
A
flexible
SERS
substrate
enables
conformable
and,
thus,
detection
but
still
with
limited
capabilities.
Stretchable
structures
controllable
hot-spot
size
provide
new
strategy
improving
efficiency
sensitivity.
This
review
summarizes
discusses
recent
development
applications
newly
conceptual
stretchable
substrates.
roadmap
reviewed,
fabrication
techniques
summarized,
followed
by
an
exhibition
these
Finally,
challenges
perspectives
presented.
provides
overview
sheds
light
design,
fabrication,
application
systems.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Sweat,
a
noninvasive
metabolic
product
of
normal
physiological
responses,
offers
valuable
clinical
insights
into
body
conditions
without
causing
harm.
Key
components
in
sweat,
such
as
urea
and
glucose,
are
closely
linked
to
kidney
function
blood
glucose
levels.
Portable
sweat
sensors,
equipped
with
diverse
sensing
systems,
can
monitor
fluctuations
concentrations,
thus
providing
methods
for
assessing
monitoring
diabetes.
This
study
presents
flexible,
portable
microfluidic
surface-enhanced
Raman
scattering
(SERS)
sensor
designed
detect
the
unique
fingerprint
target
biomarkers.
self-adhesive
chip,
constructed
from
modified
polydimethylsiloxane,
features
silver
nanotripods
(AgNTs)
densely
distributed
"hotspots"
created
via
oblique
angle
deposition
technique.
These
AgNTs
act
active
substrates
SERS
within
platform,
enabling
direct
skin
contact
collect,
transport,
store,
analyze
sweat.
The
chip
functions
quantitative
limit
detection
(LOD)
10
