Bulletin of the Korean Chemical Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
For
the
construction
of
a
nanoparticle
(NP)‐supported
drug
delivery
system
(DDS),
loading
efficiency,
stable
encapsulation,
and
targeted
are
considered
crucial
to
achieve
high
therapeutic
outcome
resulting
system.
Conventionally,
NPs
functionalized
with
desired
molecules
via
covalent
interactions,
which
do
not
only
limit
intraparticle
space
for
but
also
cause
significant
loss
preloaded
through
multistep
chemical
reactions.
Furthermore,
covalently
modified
surface
easily
surrounded
biomolecules
during
blood
circulation,
their
accumulation
in
target
site
becomes
considerably
hampered.
Keeping
these
issues
mind,
we
herein
summarize
recently
reported
unconventional
strategies
prepare
more
powerful
DDS
enhanced
targeting
ability,
by
installing
noncovalent
polymeric
gatekeeper
or
surface‐protective
biomolecular
layer
on
NP
surface.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 244 - 244
Опубликована: Фев. 12, 2025
Photodynamic
therapy
has
established
itself
as
a
clinical
treatment
for
certain
superficial
cancers
by
converting
oxygen
into
cytotoxic
singlet
to
eradicate
cancer
cells.
Porphyrin-based
nanoscale
metal-organic
frameworks
have
emerged
promising
photosensitive
platforms
due
their
ability
prevent
the
hydrophobic
aggregation
quenching
of
porphyrin
molecules
and
enhance
accumulation
at
tumor
site,
thereby
becoming
focal
point
in
photodynamic
materials
research.
However,
elevated
levels
glutathione
other
reductive
substances
within
cells
can
alleviate
oxidative
stress
induced
from
process,
thus
protecting
intracellular
biomolecular
structures
damage.
Consequently,
it
is
crucial
design
functionalized
nanoplatforms
that
integrate
depletion
with
porphyrin-based
significantly
boost
efficacy.
Moreover,
excess
disrupt
structure
frameworks,
which
not
only
increases
capacity
generate
upon
light
exposure
but
also
aids
recovery
fluorescence
imaging
capabilities.
Additionally,
this
specificity
minimizes
photosensitizing
harm
normal
tissues.
This
review
compiles
recent
advancements
developing
enhanced
phototherapy
through
depletion.
It
aims
promote
further
application
provide
valuable
insights
preclinical
applications.
By
highlighting
strategies
improve
therapeutic
outcomes
while
maintaining
safety
profiles,
summary
seeks
advance
development
more
effective
targeted
treatments.
ACS Nano,
Год журнала:
2024,
Номер
18(24), С. 15790 - 15801
Опубликована: Июнь 7, 2024
Targeted
drug
delivery
systems
based
on
metal-organic
frameworks
(MOFs)
have
progressed
tremendously
since
inception
and
are
now
widely
applicable
in
diverse
scientific
fields.
However,
translating
MOF
agents
directly
to
targeted
remains
a
challenge
due
the
biomolecular
corona
phenomenon.
Here,
we
observed
that
supramolecular
conjugation
of
antibodies
surface
particles
(MOF-808)
via
electrostatic
interactions
coordination
bonding
can
reduce
protein
adhesion
biological
environments
show
stealth
shields.
Once
stably
conjugated
particles,
they
were
neither
easily
exchanged
with
nor
covered
by
biomolecule
proteins,
which
is
indicative
effect.
Moreover,
upon
particle
specific
antibodies,
namely,
anti-CD44,
human
epidermal
growth
factor
receptor
2
(HER2),
(EGFR),
resulting
hybrid
exhibits
an
augmented
targeting
efficacy
toward
cancer
cells
overexpressing
these
receptors,
such
as
HeLa,
SK-BR-3,
4T1,
evidenced
flow
cytometry.
The
therapeutic
effectiveness
antibody-conjugated
(anti-M808)
was
further
evaluated
through
vivo
imaging
assessment
tumor
inhibition
effects
using
IR-780-loaded
EGFR-M808
4T1
xenograft
model
employing
nude
mice.
This
study
therefore
provides
insight
into
use
antibody
promising
method
for
developing
MOF-based
systems.
ABSTRACT
Metal‐organic
frameworks
(MOFs)
are
a
new
class
of
organic‐inorganic
hybrid
materials
that
have
been
widely
studied
in
the
past
two
decades
for
their
potential
catalysis.
(1)
In
this
review,
we
comprehensively
summarize
synthesis,
application,
and
advancements
MOFs
enzyme
immobilization
mimetic
enzymes.
(2)
We
also
discuss
design
principles
behind
various
MOF‐based
biocatalysts,
such
as
enzyme@MOF
composites,
explore
utility
reactions.
(3)
Additionally,
highlight
advantages
MOF
mimetics
provide
perspective
on
solutions
to
current
challenges
(4)
Ultimately,
review
provides
general
overview
most
recent
advances
catalyst
platforms,
including
biocatalysts
nanozymes,
applications.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(23), С. 29902 - 29916
Опубликована: Май 29, 2024
Metabolic
rewiring,
a
dynamic
metabolic
phenotype
switch,
confers
that
tumors
exist
and
proliferate
after
fitness
(or
preadaptation)
in
harsh
environmental
conditions.
Glycolysis
deprivation
was
considered
to
be
tumor's
Achilles
heel.
However,
configuration
can
flexibly
retune
the
mitochondrial
ability
when
glycolysis
is
scared,
potentially
resulting
more
aggressive
clones.
To
address
challenge
of
reprogramming,
an
antiglycolytic
nanoparticle
(GRPP
NP)
containing
novel
mitochondrial-targeted
reactive
oxygen
species
(ROS)
generator
(diIR780)
prepared
hijack
glucose
regulate
mitochondria,
thus
completely
eliminating
tumorigenic
energy
sources.
In
this
process,
GRPP
NPs@diIR780
catalyze
endogenous
glucose,
leading
significantly
suppressed
glycolysis.
Moreover,
diIR780
released
selectively
accumulated
around
mitochondria
generate
toxic
ROS.
These
combined
effects,
turn,
hamper
metabolism
pathways,
which
are
crucial
for
driving
tumor
progression.
This
synchronous
intervention
strategy
enables
utter
devastation
providing
promising
regiment
eradicate
lesions
without
recurrence.
Materials Chemistry Frontiers,
Год журнала:
2024,
Номер
9(2), С. 204 - 222
Опубликована: Ноя. 27, 2024
In
this
review,
the
design
idea,
synergistic
mechanism
and
application
prospects
of
l
-arginine-loaded
nanogenerators
with
cascade
NO/PDT
for
anti-tumor
applications
are
summarized.
