Accelerated healing of full-thickness skin wounds by multifunctional exosome-loaded scaffolds of alginate hydrogel/PCL nanofibers with hemostatic efficacy
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142271 - 142271
Опубликована: Март 1, 2025
Язык: Английский
Sensitizer-Passivated Magnetic Ferrite/Eu3+-Doped Oxide Nanocomposite: A Novel Luminescent Probe for Facile Bioimaging with Superior Magnetic Hyperthermia Performance
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
In
this
work,
we
design
a
magneto-luminescent
nanocomposite
system
comprised
of
magnetic
ferrite
nanoparticles
and
Ln3+-based
luminophore,
with
an
excellent
balance
lanthanide
emission
induction
heating
capacity,
which
remains
challenge.
At
first,
encapsulate
Zn-doped
(ZnxFe3–xO4;
x
≈
0.3)
size
∼20
nm
within
thin
layers
silica
amorphous
Gd2O3
doped
Eu3+
(5
atom
%),
respectively.
Then,
activate
the
luminescence
in
ZnxFe3–xO4@SiO2@Gd2O3:Eu3+
(Eu-ZFO)
nanocomposites
using
organic
ligand
2-thenoyltrifluoroacetone
(TTA)-mediated
surface
passivation
approach.
We
find
that
resulting
(Eu-ZFO-TTA
NCs)
display
bright
red
Eu3+-emission
(quantum
yield
9.3%)
under
near-UV
excitation
long
lifetime
(0.181
ms)
high
stability
against
photoluminescence
leakage.
Moreover,
witness
significant
magnetization
(39.3
emu/g)
and,
thereby,
remarkably
capacity
Eu-ZFO-TTA
NCs
than
reported
nanocomposites.
This
is
depicted
by
intrinsic
loss
power
as
11
nH
m2/kg
aqueous
dispersion
AC
field
(AMF)
12
kA/m,
335
kHz.
Finally,
examine
bioimaging
AMF-induced
hyperthermia
performance
vitro
on
human
lung
adenocarcinoma
A549
cells
live
cell
confocal
fluorescence
microscopy
study
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide
(MTT)
assay.
highly
biocompatible
(IC50
=
approximately
800
μg/mL),
their
intense
very
effective
for
monitoring
cellular
internalization.
only
200
μg/mL
dose
sufficient
to
induce
death
(>75%)
AMF.
Besides,
perform
hemolysis
test
observe
our
exhibit
hemocompatibility
at
(<5%
hemolysis).
These
outcomes
imply
immense
prospect
replace
nanomaterials
future
vivo
optical
image-guided
low-field
therapy
cancer.
Язык: Английский
Biomedical potential of alginate wound dressings – From preclinical studies to clinical applications: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
309, С. 142908 - 142908
Опубликована: Апрель 8, 2025
Язык: Английский
A natural carboxylated sisal fiber/chitosan/kaolin porous sponge for rapid and effective hemostasis
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
283, С. 137618 - 137618
Опубликована: Ноя. 15, 2024
Язык: Английский
Paramedicine Literature Search
Brenda Morrisey,
Shaughn Maxwell
International Journal of Paramedicine,
Год журнала:
2024,
Номер
6, С. 194 - 249
Опубликована: Апрель 3, 2024
search
strategy
yielded
a
total
of
1,209
citations
and
are
listed
below.
Язык: Английский
Modulating Coagulation via Bioinspired Mesoporous Calcium-Decorated Silica Nanoparticles for Efficient Fibrin Clot Formation
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 22, 2024
Blood
clotting
is
vital
for
preventing
bleeding
after
an
injury.
Hemostasis
a
complex
cascade
involving
numerous
plasma
proteins.
Uncontrolled
leads
to
mortality.
The
presence
of
Ca
(calcium)
activates
and
promotes
the
different
phases
in
coagulation
cascade.
Even
nonbiological
surfaces
such
as
silicates
may
activate
factor
XII
(FXII).
This
causes
blood.
exceptional
hemostatic
ability
mesoporous
calcium-decorated
silica
nanoparticles
(MCSNs)
achieved
by
stimulating
factors
needed
form
fibrin
mesh,
durable
clot,
thereby
establishing
hemostasis.
be
used
agent
during
accident
surgical
procedure
other
bleeding-related
trauma
conditions.
study
investigates
mechanistic
activation
MCSN
through
blood
index,
time,
studies
like
PT
aPTT.
Our
finding
demonstrates
that
induces
platelet
adhesion
RBC
aggregation
thrombin
generation
distinct
pathways.
Язык: Английский