Modulating Coagulation via Bioinspired Mesoporous Calcium-Decorated Silica Nanoparticles for Efficient Fibrin Clot Formation DOI

Marvaan MS,

G. Devanand Venkatasubbu

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 22, 2024

Blood clotting is vital for preventing bleeding after an injury. Hemostasis a complex cascade involving numerous plasma proteins. Uncontrolled leads to mortality. The presence of Ca (calcium) activates and promotes the different phases in coagulation cascade. Even nonbiological surfaces such as silicates may activate factor XII (FXII). This causes blood. exceptional hemostatic ability mesoporous calcium-decorated silica nanoparticles (MCSNs) achieved by stimulating factors needed form fibrin mesh, durable clot, thereby establishing hemostasis. be used agent during accident surgical procedure other bleeding-related trauma conditions. study investigates mechanistic activation MCSN through blood index, time, studies like PT aPTT. Our finding demonstrates that induces platelet adhesion RBC aggregation thrombin generation distinct pathways.

Язык: Английский

Accelerated healing of full-thickness skin wounds by multifunctional exosome-loaded scaffolds of alginate hydrogel/PCL nanofibers with hemostatic efficacy DOI
Fatemeh Ashrafi, Asrin Emami, Sepideh Sefidbakht

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142271 - 142271

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Sensitizer-Passivated Magnetic Ferrite/Eu3+-Doped Oxide Nanocomposite: A Novel Luminescent Probe for Facile Bioimaging with Superior Magnetic Hyperthermia Performance DOI
Anindita Das,

Ravindra Kumar Meena,

Ravi Kumar

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

In this work, we design a magneto-luminescent nanocomposite system comprised of magnetic ferrite nanoparticles and Ln3+-based luminophore, with an excellent balance lanthanide emission induction heating capacity, which remains challenge. At first, encapsulate Zn-doped (ZnxFe3–xO4; x ≈ 0.3) size ∼20 nm within thin layers silica amorphous Gd2O3 doped Eu3+ (5 atom %), respectively. Then, activate the luminescence in ZnxFe3–xO4@SiO2@Gd2O3:Eu3+ (Eu-ZFO) nanocomposites using organic ligand 2-thenoyltrifluoroacetone (TTA)-mediated surface passivation approach. We find that resulting (Eu-ZFO-TTA NCs) display bright red Eu3+-emission (quantum yield 9.3%) under near-UV excitation long lifetime (0.181 ms) high stability against photoluminescence leakage. Moreover, witness significant magnetization (39.3 emu/g) and, thereby, remarkably capacity Eu-ZFO-TTA NCs than reported nanocomposites. This is depicted by intrinsic loss power as 11 nH m2/kg aqueous dispersion AC field (AMF) 12 kA/m, 335 kHz. Finally, examine bioimaging AMF-induced hyperthermia performance vitro on human lung adenocarcinoma A549 cells live cell confocal fluorescence microscopy study 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. highly biocompatible (IC50 = approximately 800 μg/mL), their intense very effective for monitoring cellular internalization. only 200 μg/mL dose sufficient to induce death (>75%) AMF. Besides, perform hemolysis test observe our exhibit hemocompatibility at (<5% hemolysis). These outcomes imply immense prospect replace nanomaterials future vivo optical image-guided low-field therapy cancer.

Язык: Английский

Процитировано

0

Biomedical potential of alginate wound dressings – From preclinical studies to clinical applications: A review DOI
Łukasz Mazurek, Mehmet Emin Kuş,

Jan Jurak

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 309, С. 142908 - 142908

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0

A natural carboxylated sisal fiber/chitosan/kaolin porous sponge for rapid and effective hemostasis DOI
Shuo Tang,

Haoting Niu,

Yuqing Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137618 - 137618

Опубликована: Ноя. 15, 2024

Язык: Английский

Процитировано

2

Paramedicine Literature Search DOI Creative Commons

Brenda Morrisey,

Shaughn Maxwell

International Journal of Paramedicine, Год журнала: 2024, Номер 6, С. 194 - 249

Опубликована: Апрель 3, 2024

search strategy yielded a total of 1,209 citations and are listed below.

Язык: Английский

Процитировано

0

Modulating Coagulation via Bioinspired Mesoporous Calcium-Decorated Silica Nanoparticles for Efficient Fibrin Clot Formation DOI

Marvaan MS,

G. Devanand Venkatasubbu

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 22, 2024

Blood clotting is vital for preventing bleeding after an injury. Hemostasis a complex cascade involving numerous plasma proteins. Uncontrolled leads to mortality. The presence of Ca (calcium) activates and promotes the different phases in coagulation cascade. Even nonbiological surfaces such as silicates may activate factor XII (FXII). This causes blood. exceptional hemostatic ability mesoporous calcium-decorated silica nanoparticles (MCSNs) achieved by stimulating factors needed form fibrin mesh, durable clot, thereby establishing hemostasis. be used agent during accident surgical procedure other bleeding-related trauma conditions. study investigates mechanistic activation MCSN through blood index, time, studies like PT aPTT. Our finding demonstrates that induces platelet adhesion RBC aggregation thrombin generation distinct pathways.

Язык: Английский

Процитировано

0