Folate-targeted nanoparticles for glutamine metabolism inhibition enhance anti-tumor immunity and suppress tumor growth in ovarian cancer
Journal of Controlled Release,
Год журнала:
2025,
Номер
379, С. 89 - 104
Опубликована: Янв. 8, 2025
Язык: Английский
A Multifunctional MIL-101-NH2(Fe) Nanoplatform for Synergistic Melanoma Therapy
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 969 - 988
Опубликована: Янв. 1, 2025
Melanoma
is
an
aggressive
form
of
skin
cancer,
and
single-modality
treatments
often
fail
to
prevent
tumor
recurrence
metastasis.
Combination
therapy
has
emerged
as
effective
approach
improve
treatment
outcomes.
In
this
study,
we
developed
a
multifunctional
nanoplatform,
MIL@DOX@ICG,
utilizing
MIL-101-NH2(Fe)
carrier
co-deliver
the
chemotherapeutic
agent
doxorubicin
(DOX)
photosensitizer
indocyanine
green
(ICG).
was
synthesized
via
hydrothermal
method.
Drug
release
evaluated
under
different
pH
conditions,
photothermal
effect
tested
near-infrared
(NIR)
laser
irradiation.
Hydroxyl
radical
reactive
oxygen
species
generation
capacities
were
quantified.
Cellular
studies
using
B16F10
cells
assessed
cytotoxicity,
cellular
uptake,
migration
inhibition,
colony
formation
suppression.
vivo
experiments
in
melanoma-bearing
mice
antitumor
efficacy
systemic
safety
through
growth
histological
analyses,
toxicity
assessments.
MIL@DOX@ICG
exhibited
uniform
octahedral
structure
with
particle
size
approximately
139
nm
high
drug
loading
efficiencies
for
DOX
(33.70%)
ICG
(30.59%).
The
nanoplatform
demonstrated
pH-responsive
potent
effects.
hydroxyl
radicals
Fenton
reaction
production
NIR
irradiation
by
confirmed.
vitro
assessments
revealed
significant
cytotoxicity
against
irradiation,
improved
inhibiting
cell
proliferation
migration.
confirmed
superior
+
treatment,
synergistically
harnessing
chemotherapy,
therapy,
photodynamic
chemodynamic
effects
while
maintaining
excellent
biocompatibility.
Our
findings
underscore
potential
nanoparticles
versatile
platform
synergistic
melanoma
offering
promising
strategy
overcoming
limitations
conventional
modalities.
Язык: Английский
Advances in the use of nanotechnology for treating gout
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Янв. 28, 2025
Gout
is
a
commonly
occurring
form
of
inflammatory
arthritis
caused
by
persistently
elevated
levels
uric
acid.
Its
incidence
rate
rises
with
the
increases
living
standards
and
poor
dietary
habits,
which
has
considerable
impact
on
quality
life
patients.
Although
there
wide
assortment
drugs
available
for
management
gout,
effectiveness
security
these
are
limited
their
chemical
stability
insufficient
targeting.
Therefore,
development
effective
nanomedicine
systems
to
overcome
problems
treat
gout
becomes
high
priority.
This
review
provides
detailed
introduction
research
progress
developing
advanced
nanomedicines
using
polymers,
hydrogel,
nanocapsules,
lipids,
bionic
vesicles,
inorganic
artificial
organelles
electronically
controlled
conveyor
carriers
improve
therapy.
Язык: Английский
Advances in nano drug delivery systems for enhanced efficacy of emodin in cancer therapy
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
9, С. 100314 - 100314
Опубликована: Дек. 25, 2024
Cancer
remains
one
of
the
leading
causes
death
worldwide,
highlighting
urgent
need
for
novel
antitumor
drugs.
Natural
products
have
long
been
a
crucial
source
anticancer
agents.
Among
these,
emodin
(EMO),
multifunctional
anthraquinone
compound,
exhibits
significant
effects
but
is
hindered
in
clinical
applications
by
challenges
such
as
low
solubility,
rapid
metabolism,
poor
bioavailability,
and
off-target
toxicity.
Nano
drug
delivery
systems
offer
effective
strategies
to
overcome
these
limitations
enhancing
stability,
targeting
ability
EMO.
While
substantial
progress
has
made
developing
EMO-loaded
nanoformulations,
comprehensive
review
on
this
topic
still
lacking.
This
paper
aims
fill
gap
providing
an
overview
recent
advancements
nanocarriers
EMO
their
applications.
These
carriers
include
liposomes,
nanoparticles,
polymeric
micelles,
nanogels,
others,
with
nanoparticle-based
formulations
being
most
extensively
explored.
Nanoformulations
encapsulating
demonstrated
promising
therapeutic
results
against
various
cancers,
particularly
breast
cancer,
followed
liver
lung
cancers.
We
systematically
summarize
preparation
methods,
materials,
physicochemical
properties
nanopreparations,
underscoring
key
findings
how
nanotechnology
improves
efficacy
provides
valuable
insights
researchers
engaged
nano
Язык: Английский
Advancements in Betulinic Acid-Loaded Nanoformulations for Enhanced Anti-Tumor Therapy
Ke Wang,
Jinlu Shang,
Chao Tao
и другие.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 14075 - 14103
Опубликована: Дек. 1, 2024
Betulinic
acid
(BA)
is
a
natural
compound
obtained
from
plant
extracts
and
known
for
its
diverse
pharmacological
effects,
including
anti-tumor,
antibacterial,
anti-inflammatory,
antiviral,
anti-atherosclerotic
properties.
Its
potential
in
anti-tumor
therapy
has
garnered
considerable
attention,
particularly
the
treatment
of
breast,
lung,
liver
cancers.
However,
clinical
utility
BA
greatly
hindered
by
poor
water
solubility,
low
bioavailability,
off-target
toxicity.
To
address
these
issues,
researchers
have
developed
various
BA-loaded
nanoformulations,
such
as
nanoparticles,
liposomes,
micelles,
nanofibers,
aiming
to
improve
solubility
prolong
plasma
half-life,
enhance
targeting
ability,
thereby
augmenting
anti-cancer
efficacy.
In
preparing
this
review,
we
conducted
extensive
searches
well-known
databases,
PubMed,
Web
Science,
ScienceDirect,
using
keywords
like
"betulinic
acid",
"nanoparticles",
"drug
delivery",
"tumor",
"cancer",
covering
literature
2014
2024.
The
review
provides
comprehensive
overview
recent
advancements
application
nano-delivery
systems
offers
insights
into
their
future
development
prospects.
Язык: Английский
Advances in nanodelivery systems based on apoptosis strategies for enhanced rheumatoid arthritis therapy
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
A ZIF-8 nano drug delivery system that inhibits protective autophagy in cancer cells for enhancing photothermal antitumor therapy
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106954 - 106954
Опубликована: Апрель 1, 2025
Язык: Английский
Polydopamine‐Integrated Nanomedicine through Dual Metabolic Intervention with Enhanced Photothermal Therapy against Triple‐Negative Breast Cancer
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 22, 2025
Abstract
Combining
metabolic
therapy
with
photothermal
(PTT)
shows
promise
for
the
treatment
of
triple‐negative
breast
cancer
(TNBC).
However,
a
strategy
is
still
required
to
effectively
overcome
adaptation
TNBC
thermotolerance
during
thermotherapy,
thereby
enhancing
therapeutic
outcomes.
In
this
study,
polydopamine‐integrated
nanomedicine
designed,
glucose
oxidase
(GOx)
chemically
conjugated
its
surface
and
curcumin
(Cur)‐loaded
calcium
phosphate
(CaP)
shell.
The
outer
CaP
layer
disintegrates
in
response
acidic
environment
tumor
cells,
releasing
ions
efflux
inhibitor
Cur,
which
causes
mitochondrial
functional
disruption
by
inducing
overload.
Concurrently,
GOx
consumes
intracellular
inhibit
glycolysis.
dual
intervention
metabolism
glycolysis
serves
counteract
adaptations
TNBC,
blocking
pathways
energy
supply,
results
56.61%
reduction
ATP.
addition,
inhibition
ATP
production
regulation
can
downregulate
expression
heat
shock
proteins
(HSPs)
sensitized
PTT,
HSP70
level
HSP90
are
downregulated
25.68%
41.89%,
respectively.
This
study
provides
new
insights
into
combining
PTT
TNBC.
Язык: Английский
Programmable Nanomodulators for Precision Therapy, Engineering Tumor Metabolism to Enhance Therapeutic Efficacy
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Ноя. 12, 2024
Tumor
metabolism
is
crucial
in
the
continuous
advancement
and
complex
growth
of
cancer.
The
emerging
field
nanotechnology
has
made
significant
strides
enhancing
understanding
metabolic
intricacies
inherent
to
tumors,
offering
potential
avenues
for
their
strategic
manipulation
achieve
therapeutic
goals.
This
comprehensive
review
delves
into
interplay
between
tumor
various
facets
cancer,
encompassing
its
origins,
progression,
formidable
challenges
posed
by
metastasis.
Simultaneously,
it
underscores
classification
programmable
nanomodulators
transformative
impact
on
cancer
treatment,
particularly
when
integrated
with
modalities
such
as
chemotherapy,
radiotherapy,
immunotherapy.
also
encapsulates
mechanisms
which
modulate
metabolism,
including
delivery
inhibitors,
regulation
oxidative
stress,
pH
value
modulation,
nanoenzyme
catalysis,
nutrient
deprivation,
RNA
interference
technology,
among
others.
Additionally,
prospects
clinical
applications.
Finally,
innovative
concept
using
reprogram
pathways
introduced,
aiming
transform
cells
back
normal
cells.
profound
that
tailored
can
have
metabolic,
charting
a
path
toward
pioneering
precision
therapies
Язык: Английский