Programmable Nanomodulators for Precision Therapy, Engineering Tumor Metabolism to Enhance Therapeutic Efficacy DOI
Siwei Liu, Zhijun Liu, Huajiang Lei

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)

Опубликована: Ноя. 12, 2024

Tumor metabolism is crucial in the continuous advancement and complex growth of cancer. The emerging field nanotechnology has made significant strides enhancing understanding metabolic intricacies inherent to tumors, offering potential avenues for their strategic manipulation achieve therapeutic goals. This comprehensive review delves into interplay between tumor various facets cancer, encompassing its origins, progression, formidable challenges posed by metastasis. Simultaneously, it underscores classification programmable nanomodulators transformative impact on cancer treatment, particularly when integrated with modalities such as chemotherapy, radiotherapy, immunotherapy. also encapsulates mechanisms which modulate metabolism, including delivery inhibitors, regulation oxidative stress, pH value modulation, nanoenzyme catalysis, nutrient deprivation, RNA interference technology, among others. Additionally, prospects clinical applications. Finally, innovative concept using reprogram pathways introduced, aiming transform cells back normal cells. profound that tailored can have metabolic, charting a path toward pioneering precision therapies

Язык: Английский

Folate-targeted nanoparticles for glutamine metabolism inhibition enhance anti-tumor immunity and suppress tumor growth in ovarian cancer DOI
Shuning Chen, Yu Jiang, Jiao Zheng

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 89 - 104

Опубликована: Янв. 8, 2025

Язык: Английский

Процитировано

1

A Multifunctional MIL-101-NH2(Fe) Nanoplatform for Synergistic Melanoma Therapy DOI Creative Commons

Jinlu Shang,

Yongjun Chen, Fangliang Wang

и другие.

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 969 - 988

Опубликована: Янв. 1, 2025

Melanoma is an aggressive form of skin cancer, and single-modality treatments often fail to prevent tumor recurrence metastasis. Combination therapy has emerged as effective approach improve treatment outcomes. In this study, we developed a multifunctional nanoplatform, MIL@DOX@ICG, utilizing MIL-101-NH2(Fe) carrier co-deliver the chemotherapeutic agent doxorubicin (DOX) photosensitizer indocyanine green (ICG). was synthesized via hydrothermal method. Drug release evaluated under different pH conditions, photothermal effect tested near-infrared (NIR) laser irradiation. Hydroxyl radical reactive oxygen species generation capacities were quantified. Cellular studies using B16F10 cells assessed cytotoxicity, cellular uptake, migration inhibition, colony formation suppression. vivo experiments in melanoma-bearing mice antitumor efficacy systemic safety through growth histological analyses, toxicity assessments. MIL@DOX@ICG exhibited uniform octahedral structure with particle size approximately 139 nm high drug loading efficiencies for DOX (33.70%) ICG (30.59%). The nanoplatform demonstrated pH-responsive potent effects. hydroxyl radicals Fenton reaction production NIR irradiation by confirmed. vitro assessments revealed significant cytotoxicity against irradiation, improved inhibiting cell proliferation migration. confirmed superior + treatment, synergistically harnessing chemotherapy, therapy, photodynamic chemodynamic effects while maintaining excellent biocompatibility. Our findings underscore potential nanoparticles versatile platform synergistic melanoma offering promising strategy overcoming limitations conventional modalities.

Язык: Английский

Процитировано

1

Advances in the use of nanotechnology for treating gout DOI
Yizhen Wang, Zixuan Wang, Hui Jiang

и другие.

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 15

Опубликована: Янв. 28, 2025

Gout is a commonly occurring form of inflammatory arthritis caused by persistently elevated levels uric acid. Its incidence rate rises with the increases living standards and poor dietary habits, which has considerable impact on quality life patients. Although there wide assortment drugs available for management gout, effectiveness security these are limited their chemical stability insufficient targeting. Therefore, development effective nanomedicine systems to overcome problems treat gout becomes high priority. This review provides detailed introduction research progress developing advanced nanomedicines using polymers, hydrogel, nanocapsules, lipids, bionic vesicles, inorganic artificial organelles electronically controlled conveyor carriers improve therapy.

Язык: Английский

Процитировано

1

Advances in nano drug delivery systems for enhanced efficacy of emodin in cancer therapy DOI Creative Commons

Zhenghao Ai,

Bingyao Liu, Junyan Chen

и другие.

International Journal of Pharmaceutics X, Год журнала: 2024, Номер 9, С. 100314 - 100314

Опубликована: Дек. 25, 2024

Cancer remains one of the leading causes death worldwide, highlighting urgent need for novel antitumor drugs. Natural products have long been a crucial source anticancer agents. Among these, emodin (EMO), multifunctional anthraquinone compound, exhibits significant effects but is hindered in clinical applications by challenges such as low solubility, rapid metabolism, poor bioavailability, and off-target toxicity. Nano drug delivery systems offer effective strategies to overcome these limitations enhancing stability, targeting ability EMO. While substantial progress has made developing EMO-loaded nanoformulations, comprehensive review on this topic still lacking. This paper aims fill gap providing an overview recent advancements nanocarriers EMO their applications. These carriers include liposomes, nanoparticles, polymeric micelles, nanogels, others, with nanoparticle-based formulations being most extensively explored. Nanoformulations encapsulating demonstrated promising therapeutic results against various cancers, particularly breast cancer, followed liver lung cancers. We systematically summarize preparation methods, materials, physicochemical properties nanopreparations, underscoring key findings how nanotechnology improves efficacy provides valuable insights researchers engaged nano

Язык: Английский

Процитировано

4

Advancements in Betulinic Acid-Loaded Nanoformulations for Enhanced Anti-Tumor Therapy DOI Creative Commons
Ke Wang,

Jinlu Shang,

Chao Tao

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 14075 - 14103

Опубликована: Дек. 1, 2024

Betulinic acid (BA) is a natural compound obtained from plant extracts and known for its diverse pharmacological effects, including anti-tumor, antibacterial, anti-inflammatory, antiviral, anti-atherosclerotic properties. Its potential in anti-tumor therapy has garnered considerable attention, particularly the treatment of breast, lung, liver cancers. However, clinical utility BA greatly hindered by poor water solubility, low bioavailability, off-target toxicity. To address these issues, researchers have developed various BA-loaded nanoformulations, such as nanoparticles, liposomes, micelles, nanofibers, aiming to improve solubility prolong plasma half-life, enhance targeting ability, thereby augmenting anti-cancer efficacy. In preparing this review, we conducted extensive searches well-known databases, PubMed, Web Science, ScienceDirect, using keywords like "betulinic acid", "nanoparticles", "drug delivery", "tumor", "cancer", covering literature 2014 2024. The review provides comprehensive overview recent advancements application nano-delivery systems offers insights into their future development prospects.

Язык: Английский

Процитировано

3

Advances in nanodelivery systems based on apoptosis strategies for enhanced rheumatoid arthritis therapy DOI
Zongquan Zhang, Yilin Liu, Xiaoya Liang

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

A ZIF-8 nano drug delivery system that inhibits protective autophagy in cancer cells for enhancing photothermal antitumor therapy DOI

Yu Sun,

Jianfang Cen,

Liyun Yang

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106954 - 106954

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Polydopamine‐Integrated Nanomedicine through Dual Metabolic Intervention with Enhanced Photothermal Therapy against Triple‐Negative Breast Cancer DOI

Chenlu Xu,

Yujuan Gao, Xiaoyu Zhang

и другие.

Advanced Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Май 22, 2025

Abstract Combining metabolic therapy with photothermal (PTT) shows promise for the treatment of triple‐negative breast cancer (TNBC). However, a strategy is still required to effectively overcome adaptation TNBC thermotolerance during thermotherapy, thereby enhancing therapeutic outcomes. In this study, polydopamine‐integrated nanomedicine designed, glucose oxidase (GOx) chemically conjugated its surface and curcumin (Cur)‐loaded calcium phosphate (CaP) shell. The outer CaP layer disintegrates in response acidic environment tumor cells, releasing ions efflux inhibitor Cur, which causes mitochondrial functional disruption by inducing overload. Concurrently, GOx consumes intracellular inhibit glycolysis. dual intervention metabolism glycolysis serves counteract adaptations TNBC, blocking pathways energy supply, results 56.61% reduction ATP. addition, inhibition ATP production regulation can downregulate expression heat shock proteins (HSPs) sensitized PTT, HSP70 level HSP90 are downregulated 25.68% 41.89%, respectively. This study provides new insights into combining PTT TNBC.

Язык: Английский

Процитировано

0

Programmable Nanomodulators for Precision Therapy, Engineering Tumor Metabolism to Enhance Therapeutic Efficacy DOI
Siwei Liu, Zhijun Liu, Huajiang Lei

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)

Опубликована: Ноя. 12, 2024

Tumor metabolism is crucial in the continuous advancement and complex growth of cancer. The emerging field nanotechnology has made significant strides enhancing understanding metabolic intricacies inherent to tumors, offering potential avenues for their strategic manipulation achieve therapeutic goals. This comprehensive review delves into interplay between tumor various facets cancer, encompassing its origins, progression, formidable challenges posed by metastasis. Simultaneously, it underscores classification programmable nanomodulators transformative impact on cancer treatment, particularly when integrated with modalities such as chemotherapy, radiotherapy, immunotherapy. also encapsulates mechanisms which modulate metabolism, including delivery inhibitors, regulation oxidative stress, pH value modulation, nanoenzyme catalysis, nutrient deprivation, RNA interference technology, among others. Additionally, prospects clinical applications. Finally, innovative concept using reprogram pathways introduced, aiming transform cells back normal cells. profound that tailored can have metabolic, charting a path toward pioneering precision therapies

Язык: Английский

Процитировано

2