Nanoscale, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 27, 2024
We utilize coarse-grained molecular dynamics simulations and enhanced sampling methods to reveal the effect of ligand branching on thermodynamics nanoparticle adsorption lipid bilayers.
Язык: Английский
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 177, С. 117801 - 117801
Опубликована: Июнь 7, 2024
Язык: Английский
Процитировано
7
FEBS Open Bio, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Dimethyl fumarate (DMF) is an anti‐inflammatory and immunoregulatory medication used to treat multiple sclerosis (MS) psoriasis. Its skin sensitization property precludes its topical use, which unfortunate for the treatment of Isosorbide di‐(methyl fumarate) (IDMF), a novel derivative DMF, was synthesized circumvent this adverse reaction unlock potential delivery, could be useful treating psoriasis in subpopulation psoriatic MS patients, as well general population. Here, we compared therapeutic non‐sensitizing with DMF version Diroximel three skin‐ neuroinflammation models: lck‐GFP zebrafish, activated BV‐2 murine microglia human T‐lymphocyte Jurkat cell line. The results provide comparative evaluation bioactivity these related chemical entities models relevant expose several advantages unique IDMF.
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2025, Номер 13(4), С. 781 - 781
Опубликована: Март 23, 2025
Psoriasis is an immune-related disorder that marked by abnormal thickening of the skin, rapid multiplication keratinocytes, and complex interactions between immune cells affected areas. Although psoriasis cannot currently be cured, drugs can alleviate symptoms regulating homeostasis preventing comorbidities. There are many types to treat psoriasis: small-molecule drugs, including corticosteroids; retinoids; vitamin D analogs; immunosuppressants, such as glucocorticoid ointment, tretinoin cream, methotrexate tablets, etc. Macromolecular biological Certolizumab, Secukinumab, Guselkumab, etc., include monoclonal antibodies target various inflammatory signaling pathways. Compared with traditional therapies offer better targeting lower systemic side effects, but their high costs invasive administration modes constrict widespread use. Spesolimab latest agent used interleukin-36 receptor (IL-36R) approved for market use, which significantly reduces risk general pustular (GPP) flare 84%. Additionally, there several agents interleukin-23/T helper 17 cell pathway have already entered Phase II III clinical trials. At present, first-line therapeutic strategy mild topical administration. Systemic therapy phototherapy preferred treating moderate severe types. However, current completely meet needs. More advanced drug delivery systems optimized effects bioavailability required. Nanocarriers emerging proteins, nucleic acids, cell-based therapies. In this review, we analyze status therapeutics discuss novel diverse well We also summarize effectiveness different strategies.
Язык: Английский
Процитировано
0
Nano Letters, Год журнала: 2024, Номер 24(36), С. 11302 - 11310
Опубликована: Авг. 30, 2024
Bradyarrhythmia poses a serious threat to human health, with chronic progression causing heart failure and acute onset leading sudden death. In this study, we develop scalable drug-mimicking nanoplasmonic therapeutic strategy by introducing gold nanorod (Au NR) mediated near-infrared (NIR) photothermal effects. An integrated sensing regulation platform is established for in situ synchronized NIR laser electrophysiological property recording. The Au NR plasmonic enables the restoration of normal cardiomyocyte rhythm from bradyarrhythmia. By regulating aspect ratio concentration NRs, as well intensity time irradiation, precisely optimized effect explore effective strategies. Furthermore, mRNA sequencing revealed significant increase number differentially expressed genes (DEGs) involved activities cardiomyocytes following therapy. NR-mediated therapy, an efficient noninvasive approach bradyarrhythmia, holds profound implications cardiology research.
Язык: Английский
Процитировано
2
Dalton Transactions, Год журнала: 2024, Номер 53(34), С. 14315 - 14324
Опубликована: Янв. 1, 2024
A NIR/pH dual-responsive hollow CuS@AuNRs/PDA nanocarrier with synergistically enhanced photothermal efficiency was prepared by electrostatic self-assembly method.
Язык: Английский
Процитировано
1
Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(12)
Опубликована: Дек. 5, 2024
Psoriasis is a chronic and incurable skin inflammation driven by an abnormal immune response. Our study aims to investigate the potential of interferon-γ (IFN-γ) primed mesenchymal stem cells (IMSCs) in targeting T attenuate psoriasis-like inflammation, elucidate underlying molecular mechanism involved. Mesenchymal (MSCs) were isolated from umbilical cord identified based on their surface markers. models established then treated with IMSCs. Flow cytometry analysis was used examine cell markers percentages. Indoleamine-2,3-dioxygenase (IDO) knocked down small interfering RNA (siRNA) examined western blot assay. The proliferative capacity assessed using water-soluble tetrazolium salt-1(WST-1). Additionally, immunohistochemical assay determine epidermal thickness. psoriasis area severity index (PASI) scores also assessed. We observed significant therapeutic efficacy IMSCs against mice. Treatment resulted notable reduction infiltration within psoriatic lesions. Furthermore, we demonstrated that mediated upregulation IDO through IFN-γ stimulation. In vitro, inhibited proliferation, vivo, eliminated when MSCs transfected siRNA. can treat suppressing suppression IDO.
Язык: Английский
Процитировано
0
Journal of Biomedical Research, Год журнала: 2024, Номер 38, С. 1 - 1
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Nanoscale, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 27, 2024
We utilize coarse-grained molecular dynamics simulations and enhanced sampling methods to reveal the effect of ligand branching on thermodynamics nanoparticle adsorption lipid bilayers.
Язык: Английский
Процитировано
0