Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(16), С. 4679 - 4679
Опубликована: Авг. 9, 2024
The
complex
relationship
between
trace
elements
and
skeletal
health
has
received
increasing
attention
in
the
scientific
community.
Among
these
minerals,
manganese
(Mn)
emerged
as
a
key
element
affecting
bone
metabolism
integrity.
This
review
examines
multifaceted
role
of
Mn
health,
including
its
effects
on
regeneration,
mineralization,
overall
strength.
article
is
based
synthesis
experimental
models,
epidemiologic
studies,
clinical
trials
mechanisms
effect
metabolism.
Current
research
data
show
that
actively
involved
processes
remodeling
by
modulating
activity
osteoblasts
osteoclasts,
well
main
cells
regulate
formation
resorption.
ions
have
profound
mineralization
density
intricately
regulating
signaling
pathways
enzymatic
reactions
cells.
Additionally,
superoxide
dismutase
(MnSOD),
located
mitochondria,
plays
crucial
osteoclast
differentiation
function,
protecting
osteoclasts
from
oxidative
damage.
Understanding
nuances
Mn’s
interaction
with
essential
for
optimizing
strategies,
potentially
preventing
managing
diseases.
Key
findings
include
stimulation
osteoblast
proliferation
differentiation,
inhibition
osteoclastogenesis,
preservation
mass
through
RANK/RANKL/OPG
pathway.
These
results
underscore
importance
maintaining
highlight
need
further
into
therapeutic
potential.
Materials & Design,
Год журнала:
2024,
Номер
243, С. 113091 - 113091
Опубликована: Июнь 14, 2024
Amidst
the
rapid
advancements
in
materials
science,
exploration
of
aerogel-based
biomaterials
has
garnered
extensive
attention
across
diverse
sectors,
including
biomedicine,
energy,
architecture,
and
sensing.
Comprehensive
studies
have
unveiled
utilization
organic,
inorganic,
hybridized
for
aerogel
preparation,
catapulting
to
global
prominence.
Endowed
with
distinctive
properties,
low
density,
a
hierarchical
porous
network,
high
porosity,
nanoscale
micropores,
aerogels
exhibited
broad
spectrum
applications,
particularly
realm
tissue
engineering.
The
deployment
engineering
is
dynamic
phase
development,
available
reports
indicating
varying
degrees
fields
such
as
blood
vessels,
soft
tissues,
nerves,
skin,
muscles,
heart,
bronchial
tubes,
bone,
cartilage—an
evolutionary
process.
This
paper
offers
comprehensive
review
evolution
properties
preparation
processes,
encapsulating
strategic
insights
application
It
succinctly
summarizes
recent
developments
research,
emphasizing
their
significance.
Additionally,
outlines
future
prospects
envisions
challenges
arising
from
current
studies.
Through
this
thorough
engineering,
aspires
make
profound
impact
on
regenerative
medicine,
offering
innovative
effective
strategies
biomedicine.
Biomimetics,
Год журнала:
2024,
Номер
9(7), С. 397 - 397
Опубликована: Июнь 30, 2024
Aerogels
are
lightweight
and
highly
porous
materials
that
have
been
found
to
great
potential
in
biomedical
research
because
of
some
their
unique
properties,
such
as
high
surface
area,
tunable
porosity,
biocompatibility.
Researchers
exploring
ways
use
aerogels
create
biomimetic
scaffolds
inspired
by
natural
extracellular
matrices
(ECMs)
for
various
applications.
Aerogel
can
serve
three-dimensional
(3D)
templates
cell
growth
tissue
regeneration,
promoting
wound
healing
repair.
Additionally,
aerogel-based
controlled
drug
delivery
systems,
where
area
porosity
enable
the
efficient
loading
release
therapeutic
agents.
In
this
review,
we
discuss
biopolymer-based
aerogel
engineering,
delivery,
biosensors.
Finally,
also
directions
development
scaffolds.
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 1095 - 1095
Опубликована: Авг. 21, 2024
Osteochondral
defect
is
a
complex
tissue
loss
disease
caused
by
arthritis,
high-energy
trauma,
and
many
other
reasons.
Due
to
the
unique
structural
characteristics
of
osteochondral
tissue,
repair
process
sophisticated
involves
regeneration
both
hyaline
cartilage
subchondral
bone.
However,
current
clinical
treatments
often
fall
short
achieving
desired
outcomes.
Tissue
engineering
bioscaffolds,
especially
those
created
via
three-dimensional
(3D)
printing,
offer
promising
solutions
for
defects
due
their
precisely
controllable
3D
structures.
The
microstructure
3D-printed
bioscaffolds
provides
an
excellent
physical
environment
cell
adhesion
proliferation,
as
well
nutrient
transport.
Traditional
mere
stimulation,
while
drug-loaded
accelerate
synergistically
combining
drug
therapy
with
stimulation.
In
this
review,
physiological
were
reviewed.
Subsequently,
latest
progress
in
was
discussed
highlighted
terms
classification,
characteristics,
applications.
perspectives
scaffold
design,
control
release,
biosafety
also
discussed.
We
hope
article
will
serve
valuable
reference
design
development
regenerative
pave
way
use
therapy.
