Potential and challenges of utilizing exosomes in osteoarthritis therapy (Review)
International Journal of Molecular Medicine,
Год журнала:
2025,
Номер
55(3)
Опубликована: Янв. 8, 2025
Exosomes
are
integral
to
the
pathophysiology
of
osteoarthritis
(OA)
due
their
roles
in
mediating
intercellular
communication
and
regulating
inflammatory
processes.
transport
bioactive
molecules,
such
as
proteins,
lipids
nucleic
acids,
which
can
influence
chondrocyte
behavior
joint
homeostasis.
Given
properties
regeneration
ability
target
damaged
tissues,
exosomes
represent
a
promising
therapeutic
avenue
for
OA
treatment.
have
potential
promoting
cartilage
repair,
reducing
inflammation
improving
overall
function.
However,
several
challenges
remain,
including
need
standardized
isolation
characterization
methods,
variability
exosomal
content,
regulatory
hurdles.
The
present
review
aims
provide
comprehensive
overview
current
understanding
exosome
mechanisms
potential,
while
also
addressing
ongoing
faced
translating
these
findings
into
clinical
practice.
By
consolidating
existing
research,
pave
way
future
studies
aimed
at
optimizing
exosome‑based
therapies
effective
management.
Язык: Английский
Current research and future potential of thermogels for sustained drug delivery
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 29, 2025
Drug
administration
is
ubiquitous
in
the
healthcare
field,
and
it
crucial
to
optimize
drug
delivery
methods
improve
efficacy,
reduce
systemic
toxicity,
enhance
patient
compliance
Thermogels
have
shown
immense
potential
due
their
injectability,
biocompatibility,
ability
provide
localized
sustained
release.
This
paper
discusses
unique
properties
of
thermogel
relation
kinetics
suitability
as
a
carrier.
Different
considerations
applications
systems
(DDS)
were
highlighted
challenges
enter
market
discussed.
A
comprehensive
literature
search
was
conducted
using
major
databases
such
PubMed,
Scopus,
Web
Science.
The
employed
relevant
keywords
identify
studies
on
DDS.
Clinicaltrials.gov
also
utilized
determine
current
state
clinical
studies.
Nonetheless,
holds
great
promise
for
future
DDS
with
research
achieving
greater
heights
terms
complexity
pursuits.
Their
flexibility
fabrication
modularity
manner
makes
material
tailor
different
be
integrated
into
various
biomedical
disciplinaries.
Язык: Английский
Exosome-loaded methacrylated silk fibroin hydrogel delays intervertebral disc degeneration by DKK2-mediated mitochondrial unfolded protein response
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 162191 - 162191
Опубликована: Март 1, 2025
Язык: Английский
Chondrocyte Mitochondrial Quality Control: A Novel Insight into Osteoarthritis and Cartilage Regeneration
Advances in Wound Care,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
Significance:
Osteoarthritis
(OA),
one
of
the
most
prevalent
joint
diseases
affecting
more
than
240
million
people,
strongly
influences
human
health
and
reduces
life
quality.
This
review
aims
to
fill
current
research
gap
regarding
application
potential
mitochondrial
quality
control
(MQC)
based
therapies
in
treatment
OA,
thereby
providing
guidance
for
future
clinical
practice.
Recent
Advances:
Chondrocytes
respond
inflammatory
microenvironment
via
an
array
signaling
pathways
thus
are
critical
cartilage
degeneration
OA
progression.
Mitochondria,
as
important
metabolic
center
chondrocytes,
play
a
vital
role
responding
stimuli.
Multiple
MQC
mechanisms,
including
antioxidant
defense,
protein
control,
DNA
repair,
dynamics,
mitophagy,
biogenesis,
sustain
homeostasis
under
pathological
conditions.
Critical
Issues:
Despite
extensive
research,
effective
remain
limited.
Elucidating
mechanisms
disease
progression
post-traumatic
repair
is
crucial.
While
preclinical
studies
demonstrate
potential,
translation
requires
addressing
protocol
standardization,
patient
stratification,
long-term
efficacy,
well
safety
validation.
Future
Directions:
should
focus
on
developing
personalized
MQC-based
guided
by
biomarker
profiling
pathway
modulation.
However,
translational
challenges
persist,
particularly
pervasive
off-target
effects,
inadequate
OA-specific
targeting
capacity,
interpatient
heterogeneity,
reliable
evaluation
therapeutic
efficacy.
Strategic
prioritization
targets
coupled
with
delivery
system
optimization
may
significantly
improve
both
translatability
outcomes.
Язык: Английский
Mitochondria in skeletal system-related diseases
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
181, С. 117505 - 117505
Опубликована: Ноя. 4, 2024
Язык: Английский
Therapeutic Controlled Release Strategies for Human Osteoarthritis
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
Osteoarthritis
is
a
progressive,
irreversible
debilitating
whole
joint
disease
that
affects
millions
of
people
worldwide.
Despite
the
availability
various
options
(non‐pharmacological
and
pharmacological
treatments
therapy,
orthobiologics,
surgical
interventions),
none
them
can
definitively
cure
osteoarthritis
in
patients.
Strategies
based
on
controlled
release
therapeutic
compounds
via
biocompatible
materials
may
provide
powerful
tools
to
enhance
spatiotemporal
delivery,
expression,
activities
candidate
agents
as
means
durably
manage
pathological
progression
affected
joints
upon
convenient
intra‐articular
(injectable)
delivery
while
reducing
their
clearance,
dissemination,
or
side
effects.
The
goal
this
review
describe
current
knowledge
advancements
treat
osteoarthritis,
from
basic
principles
applications
vivo
using
recombinant
molecules
drugs
more
innovatively
gene
sequences,
providing
degree
confidence
patients
close
future.
Язык: Английский
Current innovations in mRNA vaccines for targeting multidrug-resistant ESKAPE pathogens
Biotechnology Advances,
Год журнала:
2024,
Номер
unknown, С. 108492 - 108492
Опубликована: Дек. 1, 2024
The
prevalence
of
multidrug-resistant
(MDR)
ESKAPE
pathogens,
including
Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
and
Pseudomonas
aeruginosa,
represents
a
critical
global
public
health
challenge.
In
response,
mRNA
vaccines
offer
an
adaptable
scalable
platform
for
immunotherapy
against
pathogens
by
encoding
specific
antigens
that
stimulate
B-cell-driven
antibody
production
CD8
Язык: Английский