Cuproplasia and cuproptosis, two sides of the coin

Cancer Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 25, 2025

Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming regulatory network, defined cuproplasia. Thus, targeting chelation reduce levels has been considered rational therapy strategy. However, overloaded ions could be toxic, which leads aggregation lipoylated mitochondrial proteins depletion iron‐sulfur clusters, ultimately resulting death, termed cuproptosis. Upon its discovery, cuproptosis attracted great interest from oncologists, ionophores exhibits potential anti‐tumor therapy. In this review, we present underlying mechanisms involved cuproplasia Additionally, sum up chemicals either or cancer Further attention should paid distinguishing patients who are suitable

Язык: Английский

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Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy – Significance for cancer treatment?

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(4), С. 189124 - 189124

Опубликована: Май 25, 2024

Apoptosis has traditionally been regarded as the desired cell death pathway activated by chemotherapeutic drugs due to its controlled and non-inflammatory nature. However, recent discoveries of alternative pathways have paved way for immune-stimulatory treatment approaches in cancer. Ferroptosis (dependent on iron) cuproptosis copper) hold promise selective cancer targeting overcoming drug resistance. Copper ionophores iron-bearing nano-drugs show potential clinical therapy single agents adjuvant treatments. Here we review up-to-date evidence involvement metal ion-dependent cytotoxicity classical (alkylating agents, topoisomerase inhibitors, antimetabolites, mitotic spindle inhibitors) their combinations with ferroptosis inducers, indicating prospects, advantages, obstacles use.

Язык: Английский

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Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Abstract Copper, one of the essential nutrients for human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses copper lead cellular fragility. Therefore, it can manifest pro‐ anti‐cancer properties tumors. is crucial clarify activity within cell. We have thoughtfully summarized metabolic activities from a macro micro perspective. Cuproptosis, well other forms cell death, directly or indirectly interfered with by Cu 2+ , causing cancer death. Meanwhile, we did pan‐cancer analysis cuproptosis‐related genes further roles these genes. In addition, has been found be involved metastasis cells. Given complexity copper's role, are compelled ask: friend foe? Up now, used various clinical applications, including protocols measurement concentration bioimaging radioactive 64 Cu. But therapeutically still continuation old medicine, new possibilities need explored, such use nanomaterials. Some studies also shown that considerable interventional power cancers, which provides great applications potential therapy specific types. This paper reviews dual played cuproptosis perspectives oxidative stress, tumor metastasis, points out value application types, summarizes testing imaging perspective current feasible options drugs, emphasizes prospects nano‐copper.

Язык: Английский

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Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and Elesclomol for cancer therapy

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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An up‐To‐Date Review of Elesclomol and Its Nano‐Formulations in Cancer Therapy

Cancer Reports, Год журнала: 2025, Номер 8(4)

Опубликована: Апрель 1, 2025

ABSTRACT Background Elesclomol (ES) is a promising anticancer compound that exerts its effects through multiple mechanisms. It acts as copper (Cu(II)) ionophore, forming an ES–Cu complex within cancer cells and inducing novel form of cell death called cuproptosis. Aim To provide up‐to‐date review on elesclomol nano‐formulations with particular focus therapy. Sources Literature was collected by manually searching in Pubmed, Google Scholar, clinicaltrials.gov March 2025. Content This provides overview the discovery development ES molecule, including physicochemical properties. New insights into intracellular interactions mechanisms transportation are then explained. The recent clinical outcomes therapy, both monotherapy combination paclitaxel or carboplatin, summarized. While initial trials showed promise, more studies focusing preclinical investigations complex. Nanomedicine‐based formulations have emerged strategy to enhance delivery well therapeutic effects, several nanomedicines currently under development. nanoparticle strategies discussed. comprehensive advancements study, mechanism action, progress, potential nanomedicine‐based approaches improve efficacy treatment.

Язык: Английский

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Research progress on cuproptosis and copper related anti-tumor therapy

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 21, 2025

Copper is a trace element which essential for biological organisms, and its homeostatic balance important living organisms to maintain the normal function. When copper homeostasis disordered, cellular function structure will be disrupted. Excess cause oxidative stress DNA damage in cells, thereby inducing regulated cell death such as apoptosis necroptosis. mitochondria can bind lipoylated proteins tricarboxylic acid (TCA) cycle them aggregate, resulting proteotoxic eliciting novel modality: cuproptosis. Cancer cells have greater demand compared tissue, high levels of ions are closely associated with tumour proliferation metastasis. The anti-tumor mechanisms include production stress, inhibition ubiquitin-proteasome system, suppression angiogenesis, induction copper-dependent death. Targeting one current directions oncology research, including use ion carriers increase intracellular induce cuproptosis, well chelators reduce bioavailability. However, complexes certain toxicity, so their biosafety needs improved. Emerging nanotechnology expected solve this problem by utilizing copper-based nanomaterials (Cu-based NMs) deliver variety drugs different functions, improving efficacy reducing side effects. Therefore, thorough understanding metabolic processes mechanism cuproptosis greatly benefit therapy. This review summarizes metabolism In addition, we discuss paradigms related copper, also nanotherapeutic approaches mortality provide prospective insights into future copper-mediated cancer

Язык: Английский

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PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic Framework with Effective Nanozyme Performance and Cuproptosis Induction Efficacy for Enhanced PD-L1-based Immunotherapy

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101317 - 101317

Опубликована: Окт. 30, 2024

Язык: Английский

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Antibacterial mechanism of water-soluble CeO2 nanoflowers and its product design in antibacterial application

Applied Surface Science, Год журнала: 2024, Номер unknown, С. 161249 - 161249

Опубликована: Сен. 1, 2024

Язык: Английский

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Chondroitin sulfate sponge scaffold for slow-release Mg2+/Cu2+ in diabetic wound management: Hemostasis, effusion absorption, and healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137561 - 137561

Опубликована: Ноя. 12, 2024

Язык: Английский

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