Novel immunogenic cell death inducer combined with autophagy inhibitor to amplify photodynamic synergistic immunotherapy for triple-negative breast cancer DOI

Gankun Yuan,

Ruyue Yang,

Wenjing Wen

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Abstract Background Activating immunogenic cell death (ICD) represents a promising therapeutic strategy for tumor immunotherapy. However, photodynamic therapy (PDT)-mediated ICD effects are severely limited due to the extremely short half-life and diffusion radius of reactive oxygen species (ROS) hinder effective endoplasmic reticulum (ER) stress induction. In addition, targeted triple-negative breast cancer (TNBC) remain hugely challenging lack expression multiple receptors. Results Herein, we synthesized hierarchical targeting controllable intelligent nanodelivery material Da-CD@CET@CQ, loaded with highly efficient ER-targeted photosensitizers CET autophagy inhibitor chloroquine (CQ). Excitingly, Da-CD@CET@CQ NPs can selectively target TNBC cells was effectively released in microenvironment, enabling local accumulation ER situ ROS production, which causing stronger amplifying effect, further increasing immune suppression growth. More importantly, CQ by inhibit destroy damaged repair, enhance anti-tumor ability PDT. Conclusions Our findings indicate that reported novel photosensitizing inducer amplify combination inhibition, provides meaningful guideline PDT synergistic immunotherapy future.

Язык: Английский

Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic Immunotherapy DOI Creative Commons

Shanchao Diao,

Zhifan Zhang, Sijun Zhao

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Photodynamic immunotherapy which combines photodynamic therapy with has become an important and effective method for the treatment of cancer. However, most cancer immunotherapeutic systems are not able to achieve precise release immunomodulators, resulting in systemic side effects poor patient outcomes. Herein, a dual‐activatable nano‐immunomodulator (DIR NP), both its effect agonist can be activated under specific stimuli, is reported precision immunotherapy. The DIR NP self‐assembled from R848‐conjugated amphiphilic polymer (mPEG‐TK‐R848) hydrophobic oxidized bovine serum albumin (BSA‐SOH)‐conjugatable photosensitizer (DIR). NPs may generate small amount 1 O 2 808 nm laser irradiation, leading cleavage thioketal (TK) moiety R848 DIR. released conjugate tumor‐overexpressed BSA‐SOH, improving efficiency NIR‐II fluorescence signal. Such improvement further enhance cargoes upon irradiation. induces immunogenic cell death (ICD) immune factors maturation dendritic cells inhibiting growth primary distant tumors eliminating lung metastasis. Therefore, this study provides intelligent regulation tumor

Язык: Английский

Процитировано

0
Novel immunogenic cell death inducer combined with autophagy inhibitor to amplify photodynamic synergistic immunotherapy for triple-negative breast cancer DOI

Gankun Yuan,

Ruyue Yang,

Wenjing Wen

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Abstract Background Activating immunogenic cell death (ICD) represents a promising therapeutic strategy for tumor immunotherapy. However, photodynamic therapy (PDT)-mediated ICD effects are severely limited due to the extremely short half-life and diffusion radius of reactive oxygen species (ROS) hinder effective endoplasmic reticulum (ER) stress induction. In addition, targeted triple-negative breast cancer (TNBC) remain hugely challenging lack expression multiple receptors. Results Herein, we synthesized hierarchical targeting controllable intelligent nanodelivery material Da-CD@CET@CQ, loaded with highly efficient ER-targeted photosensitizers CET autophagy inhibitor chloroquine (CQ). Excitingly, Da-CD@CET@CQ NPs can selectively target TNBC cells was effectively released in microenvironment, enabling local accumulation ER situ ROS production, which causing stronger amplifying effect, further increasing immune suppression growth. More importantly, CQ by inhibit destroy damaged repair, enhance anti-tumor ability PDT. Conclusions Our findings indicate that reported novel photosensitizing inducer amplify combination inhibition, provides meaningful guideline PDT synergistic immunotherapy future.

Язык: Английский

Процитировано

0