Applications of plant‐derived extracellular vesicles in medicine

MedComm, Год журнала: 2024, Номер 5(10)

Опубликована: Сен. 20, 2024

Plant-derived extracellular vesicles (EVs) are promising therapeutic agents owing to their natural abundance, accessibility, and unique biological properties. This review provides a comprehensive exploration of the potential plant-derived EVs emphasizes anti-inflammatory, antimicrobial, tumor-inhibitory effects. Here, we discussed advancements in isolation purification techniques, such as ultracentrifugation size-exclusion chromatography, which critical for maintaining functional integrity these nanovesicles. Next, investigated diverse administration routes carefully weighed respective advantages challenges related bioavailability patient compliance. Moreover, elucidated multifaceted mechanisms action EVs, including roles anti-inflammation, antioxidation, antitumor activity, modulation gut microbiota. We also impact on specific diseases cancer inflammatory bowel disease, highlighting importance addressing current production scalability, regulatory compliance, immunogenicity. Finally, proposed future research directions optimizing EV extraction developing targeted delivery systems. Through efforts, envision seamless integration into mainstream medicine, offering safe potent alternatives across various medical disciplines.

Язык: Английский

Overcoming drug resistance through extracellular vesicle-based drug delivery system in cancer treatment

Cancer Drug Resistance, Год журнала: 2024, Номер unknown

Опубликована: Дек. 12, 2024

Drug resistance is a major challenge in cancer therapy that often leads to treatment failure and disease relapse. Despite advancements chemotherapeutic agents targeted therapies, cancers develop drug resistance, making these treatments ineffective. Extracellular vesicles (EVs) have gained attention for their potential applications delivery because of natural origin, biocompatibility, ability cross biological barriers. Using the unique properties EVs could enhance accumulation at target sites, minimize systemic toxicity, precisely specific cells. Here, we discuss characteristics functionalization EVs, mechanisms engineered overcome resistance. This review provides comprehensive overview EV-based systems overcoming We highlight revolutionize offer promising strategies more effective modalities.

Язык: Английский

Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis

Journal of Controlled Release, Год журнала: 2024, Номер 376, С. 318 - 336

Опубликована: Окт. 18, 2024

Язык: Английский