Nanoscale fluconazole-constructed metal-organic frameworks with smart drug release for eradication of Candida biofilms in vulvovaginitis infection
Colloids and Surfaces B Biointerfaces,
Год журнала:
2024,
Номер
245, С. 114238 - 114238
Опубликована: Сен. 11, 2024
Язык: Английский
Fabrication of chitosan-coated ciprofloxacin drug nanocomposite for combating antibacterial and respiratory infection leading to sepsis
Journal of materials research/Pratt's guide to venture capital sources,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Язык: Английский
3,4-dihydroxyhydrocinnamic acid conjugated methoxy-poly(ethylene glycol)-poly(lactic acid) polymeric micelles for Bortezomib delivery and efficacy enhancement in doxorubicin-resistant breast cancer
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106700 - 106700
Опубликована: Фев. 1, 2025
Язык: Английский
Topical Ocular Drug Delivery: The Impact of Permeation Enhancers
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 447 - 447
Опубликована: Март 31, 2025
Topical
ophthalmic
drug
delivery
targeting
the
posterior
segment
of
eye
has
become
a
key
area
interest
due
to
its
non-invasive
nature,
safety,
ease
application,
patient
compliance,
and
cost-effectiveness.
However,
achievement
effective
bioavailability
in
ocular
is
significant
challenge
unique
barriers,
including
precorneal
factors
anatomical
like
cornea,
conjunctiva,
sclera.
Successful
systems
require
increased
residence
time
improved
corneal
penetration
enhance
intraocular
bioavailability.
A
promising
strategy
overcome
these
barriers
incorporating
enhancers
(DPEs)
into
formulations.
These
compounds
facilitate
by
improving
permeability
across
otherwise
impermeable
or
poorly
permeable
membranes.
At
level,
they
act
through
three
primary
mechanisms:
breaking
tear
film
stability
interfering
with
mucous
layer;
disrupting
membrane
components
such
as
phospholipids
proteins;
loosening
epithelial
cellular
junctions.
DPEs
offer
potential
improve
therapeutic
outcomes,
particularly
for
drugs
eye.
This
review
focused
on
analyzing
current
literature
regarding
use
topical
delivery,
highlighting
their
mechanisms
action
revolutionize
treatments.
Язык: Английский
A Self‐Assembled Nanoreactor for Realizing Antibacterial Photodynamic/Gas Therapy and Promoting Wound Healing
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Abstract
Among
various
treatments
employed
to
solve
the
global
problem
of
bacterial
infection,
photodynamic
therapy
(PDT)
is
recognized
as
a
method
with
great
potential
inactivate
wide
range
bacteria
without
development
drug
resistance.
However,
many
commonly
used
photosensitizers
(PSs)
have
disadvantages
poor
water‐solubility
and
toxicity,
which
limits
their
clinical
application.
Additionally,
nitric
oxide
(NO)
has
unique
advantages
in
antibacterial
due
its
small
molecular
weight.
Herein,
protoporphyrin
IX
(PpIX),
L‐arginine
(L‐Arg),
glycol
chitosan
(GC)
are
construct
self‐assembled
cationic
Arg‐GC‐PpIX
nanoreactor
for
efficient
inactivation
under
white
light
illumination.
The
excellent
water
dispersity
stability
can
rapidly
bind
through
electrostatic
interaction
produce
local
singlet
oxygen
(
1
O
2
)/NO
irradiation,
leading
high
efficiency
toward
both
Gram‐negative
Gram‐positive
bacteria.
Besides,
these
NPs
also
possess
desirable
antibiofilm
ability.
Finally,
Arg‐GC‐PpIX@Gel
obtained
loading
into
sodium
alginate
(SA)/Ca
2+
hydrogel
shows
satisfactory
ability
promote
infected
wound
healing
when
combined
irradiation.
Therefore,
rationally
designed
light‐triggered
/NO
release
promising
agent
achieving
effective
PDT/NO
gas
therapy.
Язык: Английский
Antimicrobial Zn2+-Carboxymethyl Chitosan Cryogel for Controlled Loading and Release of Ciprofloxacin via Coordination Bonds
Gels,
Год журнала:
2024,
Номер
10(12), С. 841 - 841
Опубликована: Дек. 20, 2024
The
local
application
of
broad-spectrum
antibiotics
via
polymeric
drug
delivery
systems
is
a
promising
alternative
to
their
systemic
administration
in
wound
healing,
prevention
and
treatment
infections
associated
with
surgical
implants.
However,
low
poorly
controlled
loading
efficiency
100%
burst
release
are
common
problems
for
the
materials
weak
physical
interaction
between
matrices.
Here,
we
report
new
multifunctional
carboxymethyl
chitosan
(CMC)
cryogel,
which
efficiently
prevents
bacterial
adhesion
surface,
kills
bacteria
solution
ciprofloxacin
(CIP),
promotes
fibroblast
proliferation.
suggested
approach
based
on
CIP
Zn2+-chelated
CMC
cryogel
ligand
exchange
reaction.
We
have
shown
that,
due
strong
binding
Zn2+
CMC,
antibacterial
effect
toxicity
fibroblasts
CMC-Zn-CIP
cryogels
were
mainly
determined
by
content
loaded
CIP,
can
be
precisely
cryogel.
containing
20
mgZn/g
amounts
sufficient
completely
suppress
growth
hospital
strain
Klebsiella
oxytoca
MIC
0.125
µg/mL,
while
maintaining
viability
at
level
85–90%.
Язык: Английский