ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(30), С. 39917 - 39926
Опубликована: Июль 17, 2024
We
proposed
and
demonstrated
highly
sensitive
hybrid
surface-enhanced
Raman
scattering
(SERS)
substrates,
which
are
grating-integrated
gold
nanograsses
(GIGN)
that
tip-selectively
encapsulated
by
ZIF-8
nanospheres
(GIGN/tip-ZIF).
This
unique
structure
is
realized
through
the
tip-selective
modification
of
GIGN
polyvinylpyrrolidone
(PVP),
then,
tips
were
nanospheres.
The
can
adsorb
analyte
molecules,
resulting
in
spatial
overlap
between
molecules
"hotspots"
on
GIGN.
Such
a
GIGN/tip-ZIF
SERS
substrate
exhibits
high
sensitivity
quantitative
detection
ability.
limits
reach
as
low
10-11
M,
relative
standard
deviation
5.59%
for
4-aminothiophenol
(4-ATP).
In
wide
range
concentrations
from
10-5
to
intensity
concentration
relationship
be
fitted
sigmoidal
curve
with
R2
=
0.988.
These
indicate
substrates
have
broad
applications
detecting
toxic
harmful
substances
food
safety,
disease
diagnosis,
environmental
monitoring.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(27), С. 35771 - 35780
Опубликована: Июнь 27, 2024
Flexible
surface-enhanced
Raman
scattering
(SERS)
substrates
are
very
promising
to
meet
the
needs
for
real-time
and
on-field
detection
in
practical
applications.
However,
high-performance
flexible
SERS
often
suffer
from
complexity
high
cost
fabrication,
limiting
their
widespread
Herein,
we
developed
a
facile
method
fabricate
multicavity
substrate
composed
of
silver
nanoparticle
(AgNP)-decorated
aluminum
hydrous
oxide
nanoflake
array
(NFA)
grown
on
polydimethylsiloxane
(PDMS)
membrane.
Strong
plasmon
couplings
promoted
by
multiple
nanocavities
afford
high-density
hotspots
within
such
AgNPs@NFA/PDMS
film,
boosting
sensitivity
with
an
enhancement
factor
(EF)
∼1.54
×
109,
limit
(LOD)
∼7.4
10-13
M
rhodamine
6G
(R6G)
molecules.
Furthermore,
benefiting
sensitivity,
mechanical
stability,
transparency
this
substrate,
situ
detections
trace
thiram
crystal
violet
(CV)
molecules
surface
cherry
tomatoes
fish
have
been
realized,
LODs
much
lower
than
maximum
allowable
food,
demonstrating
great
potential
food
safety
monitoring.
More
importantly,
preparation
processes
simple
environmentally
friendly,
techniques
involved
completely
compatible
well-established
silicon
device
technologies.
Therefore,
large-area
fabrication
low
can
be
readily
enabling
extensive
applications
sensors
daily
life.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
8(2), С. 1484 - 1492
Опубликована: Янв. 31, 2025
Surface-enhanced
Raman
scattering
(SERS)
is
an
ultrasensitive
optical
technique
that
critical
for
protein
detection
and
essential
identifying
structure
concentrations
in
various
biomedical
diagnostic
applications.
However,
achieving
highly
sensitive
reproducible
SERS
signals
label-free
proteins
remains
challenging
due
to
their
weak
structural
complexity.
In
this
study,
silver
nanomushroom
arrays
(Ag
NMAs)
as
substrates
were
readily
prepared
surface-engineered
using
a
facile
template-assisted
micro-
nanofabrication
approach.
The
surface
of
the
substrate
exhibits
nanoscale
roughness,
long-range
order,
hydrophilicity,
enabling
rapid
uniform
dispersion
molecules.
These
molecules
are
anchored
through
Ag-S
bonds,
resulting
driven
by
strong
electromagnetic
enhancement
effects.
ordered
array
improves
signal
repeatability,
relative
standard
deviation
low
4.32%.
Additionally,
utilizing
silicon
characteristic
peak
internal
significantly
reduces
measurement
errors,
allowing
reliable
precise
quantitative
molecules,
with
linear
correlation
coefficient
(R2)
exceeding
0.96.
Ultrasensitive
effective
discrimination
via
principal
component
analysis
further
validate
Ag
NMA
substrate's
potential
universal
trace
detection.
This
study
presents
advanced
platform
proteins,
showcasing
significant
pharmaceutical
research,
metabolic
studies,
medicine,
engineering.
Surface and Interface Analysis,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
ABSTRACT
The
surface‐enhanced
Raman
scattering
(SERS),
dependent
on
metal
nanoparticle
substrate
structure
and
morphology,
presents
a
powerful
analytic
tool
across
diverse
fields
such
as
food
safety,
environmental
analysis,
biomedical.
Hard
materials
Si,
glass,
are
often
used
in
experimental
research.
They
highly
stable
easy
to
manufacture.
However,
the
surfaces
of
actual
samples
usually
have
different
shapes,
making
using
rigid
substrates
challenging,
so
developing
flexible
SERS
is
necessary.
In
this
study,
we
focused
blanket
polydimethylsiloxane
(PDMS)
by
spin
coating
with
area
concealed
treated
argon
plasma
jet.
plasma‐treated
area,
PDMS
surface
transformed
into
hydrophilic
form,
causing
nanoparticles
spread
flat,
even
layer
evaporate
quickly,
leading
better
effect
when
analyzing
liquid
samples.
results
show
that
limit
detection
(LOD)
sodium
metabisulfite
(SM)
up
0.01
mg/mL
relative
standard
deviation
(RSD)
15.88%.
Nanomaterials,
Год журнала:
2025,
Номер
15(6), С. 421 - 421
Опубликована: Март 9, 2025
Surface-enhanced
Raman
scattering
(SERS)
technology
has
important
applications
in
many
fields,
such
as
biomedicine,
environmental
monitoring,
and
food
safety.
Plasmonic
nanocavities
have
the
ability
to
superdiffract
localized
light
enhance
light-matter
interactions.
As
a
key
SERS
active
substrate,
research
on
plasmonic
made
significant
progress
regarding
enhancement
mechanism,
utilization
of
hotspots
for
detection
specific
molecular
groups,
practical
applications.
However,
challenges
related
improving
factor
nanocavity
SERS,
enhancing
stability
reproducibility
hotspots,
enabling
single-molecule
layers
remain.
In
this
study,
we
adopt
bottom-up
approach
construct
silver
microplate–molecule–multi-sized
nanosphere
nanoparticle-on-mirror
(NPoM)
achieve
efficient
stable
from
4-mercaptobenzoic
acid
biphenyl-4,4′-dithiol
molecules
via
electromagnetic
mechanism.
By
characterizing
fabricated
using
dark-field
micro-confocal
scattering,
observed
that
intensity
NPoM
was
enhanced
by
103
compared
individual
nanospheres.
Furthermore,
achieved
stabilization
precisely
tuning
size
nanospheres
match
their
resonance
frequency
with
shift
target
molecules.
This
offers
valuable
reference
various
demonstrates
potential
biosensing
chemical
analysis.
Abstract
Mental
stress
is
a
dangerous
factor
for
the
health
of
living
beings,
which
can
lead
to
various
diseases.
However,
currently,
there
lack
diagnostic
tools
that
quickly
and
accurately
quantify
levels
mental
stress.
Cortisol
an
important
hormone
widely
present
in
bodily
fluids;
its
concentration
reflect
level
organisms.
Here,
we
report
surface-enhanced
Raman
spectroscopy
(SERS)
probe
based
on
flower-like
graphene
oxide-molybdenum
disulfide
composite
material
functionalized
with
cortisol
DNA
recognition
element
tetracyanoquinodimethane
label,
remarkable
enhancement
value
7.38
×
10
5
,
exhibits
excellent
detection
ability
wide
range
concentrations
from
1
nM
000
nM,
limit
down
0.773
nM.
The
whole
takes
only
20
min.
In
addition,
SERS
selectively
detect
other
substances
similar
chemical
structures,
makes
applicable
complex
biological
systems
good
reproducibility
stability.
This
designed
has
been
successfully
employed
mouse
serum
cortisol,
high
accuracy
compared
enzyme-linked
immunosorbent
assay
(ELISA)
results,
demonstrating
great
potential
actual
sample
detection.
