Smart zwitterionic coatings with precise pH-responsive antibacterial functions for bone implants to combat bacterial infections
Biomaterials Science,
Год журнала:
2024,
Номер
12(17), С. 4471 - 4482
Опубликована: Янв. 1, 2024
Hydrophilic
antifouling
coatings
based
on
zwitterionic
polymers
have
been
widely
applied
for
the
surface
modification
of
bone
implants
to
combat
biofilm
formation
and
reduce
likelihood
implant-related
infections.
However,
their
long-term
effectiveness
is
significantly
limited
by
lack
effective
precise
antibacterial
activity.
Here,
a
pH-responsive
smart
coating
(PSB/GS
coating)
was
designed
robustly
fabricated
onto
titanium-base
using
facile
two-step
method.
First,
dopamine
(DA)
poly(sulfobetaine
methacrylate-
Язык: Английский
4D Printing in Dynamic and Adaptive Bone Implants: Progress in Bone Tissue Engineering
Bioprinting,
Год журнала:
2024,
Номер
unknown, С. e00373 - e00373
Опубликована: Ноя. 1, 2024
Язык: Английский
Tunable Stimuli-Responsive Module Based on α-Hydroxymethyl-α,β-Unsaturated Carbonyl Scaffold
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
α-hydroxymethyl-α,β-unsaturated
carbonyl
(HMUC)
scaffold
represents
a
valuable
framework
for
constructing
nucleophile-responsive
materials.
Язык: Английский
Immobilization of KR-12 on a Titanium Alloy Surface Using Linking Arms Improves Antimicrobial Activity and Supports Osteoblast Cytocompatibility
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
Implant-associated
infections
pose
significant
challenges
due
to
bacterial
resistance
antibiotics.
Recent
research
highlights
the
potential
of
immobilizing
antimicrobial
peptides
(AMPs)
onto
implants
as
an
alternative
conventional
antibiotics
for
prevention
infection.
While
various
AMP
immobilization
methodologies
have
been
investigated,
they
lack
responsiveness
biological
cues.
This
study
proposes
enzyme-responsive
coating
orthopedic
devices
using
KR-12,
derived
from
Cathelicidin
LL-37,
coupled
with
Human
Elastin-Like
Polypeptide
(HELP)
a
biomimetic
and
stimuli-responsive
linker,
while
mimicking
extracellular
matrix
(ECM).
During
implantation,
these
customized
interfaces
encounter
innate
immune
response
triggering
elastase
release,
which
degrades
HELP
biopolymers,
enabling
controlled
release
KR-12.
After
coupling
KR-12
titanium
surfaces,
activity
against
four
pathogenic
strains
(Staphylococcus
aureus,
Staphylococcus
epidermidis,
Escherichia
coli,
Pseudomonas
aeruginosa)
was
assessed,
revealing
inhibition
ratio
adhesion
colonization
exceeding
92%
all
tested
strains,
compared
surfaces
functionalized
only.
It
is
thought
that
enhanced
improved
mobility
when
HELP.
Furthermore,
prepared
coatings
boosted
proliferation
human
osteoblasts,
confirming
cytocompatibility.
These
findings
suggest
smart
combine
functions
AMPs
HELP's
properties
use
in
variety
settings,
including
medical
devices.
Язык: Английский
Functional Nanoparticle Developments for 3D-Printed Biodegradable Implants- A Comprehensive Review
Results in Surfaces and Interfaces,
Год журнала:
2025,
Номер
19, С. 100541 - 100541
Опубликована: Май 1, 2025
Язык: Английский
Synergetic improvement of osteogenic and antibacterial activities of TiO2 nanotubes on titanium alloys by combining Sr2+ ions with CO molecules
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 163996 - 163996
Опубликована: Май 1, 2025
Язык: Английский
Combined release of LL37 peptide and zinc ion from a mussel-inspired coating on porous titanium for infected bone defect repairing
Colloids and Surfaces B Biointerfaces,
Год журнала:
2024,
Номер
244, С. 114181 - 114181
Опубликована: Авг. 28, 2024
Язык: Английский
Strategically Engineered Ru(II) Complexes with Enhanced ROS Activity Enabling Potent Sonodynamic Effect against Multidrug-Resistant Biofilms
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 19, 2024
Sonodynamic
therapy
(SDT)
can
generate
reactive
oxygen
species
(ROS)
to
combat
multidrug-resistant
biofilms,
which
pose
significant
challenges
human
health.
As
the
key
producing
ROS
in
SDT,
design
of
sonosensitizers
with
optimal
molecular
structures
for
sufficient
generation
and
activity
complex
biofilm
matrix
is
essential.
In
this
study,
we
propose
a
π-expansion
strategy
synthesize
series
small-molecule
metal
Ru(II)
complexes
(
Язык: Английский
Phytic Acid-Gallium Network on a Polyimide Fiber Woven Fabric as an Artificial Ligament for Boosting Ligament–Bone Healing and Infection Treatment
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(31), С. 40726 - 40738
Опубликована: Июль 23, 2024
The
development
of
an
artificial
ligament
with
a
multifunction
promoting
bone
formation,
inhibiting
resorption,
and
preventing
infection
to
obtain
ligament-bone
healing
for
anterior
cruciate
(ACL)
reconstruction
still
faces
enormous
challenges.
Herein,
novel
based
on
PI
fiber
woven
fabric
(PIF)
was
fabricated,
which
coated
phytic
acid-gallium
(PA-Ga)
network
via
layer-by-layer
assembly
method
(PFPG).
Compared
PIF,
PFPG
PA-Ga
coating
significantly
suppressed
osteoclastic
differentiation,
while
it
boosted
osteoblastic
differentiation
in
vitro.
Moreover,
obviously
inhibited
fibrous
encapsulation
absorption
accelerating
new
regeneration
vivo.
remarkably
killed
bacteria
destroyed
biofilm,
exhibiting
excellent
antibacterial
properties
vitro
as
well
anti-infection
ability
vivo,
were
ascribed
the
release
Ga
ions
from
coating.
cooperative
effect
surface
characteristics
(e.g.,
hydrophilicity/surface
energy
protein
absorption)
sustained
enhanced
osteogenesis
osteoclastogenesis,
thereby
achieving
integration
resistance
infection.
In
summary,
facilitated
osteoclastogenesis
healing.
As
ligament,
represented
appealing
option
graft
selection
ACL
displayed
considerable
promise
application
clinics.
Язык: Английский