Regenerative Biomaterials,
Год журнала:
2024,
Номер
12
Опубликована: Дек. 20, 2024
Abstract
During
the
implantation
process
of
cardiovascular
implants,
vascular
damage
caused
by
inflammation
occurs,
and
inflammatory
is
accompanied
oxidative
stress.
Currently,
carbon
monoxide
(CO)
has
been
demonstrated
to
exhibit
various
biological
effects
including
vasodilatation,
antithrombotic,
anti-inflammatory,
apoptosis-inducing
antiproliferative
properties.
In
this
study,
hemoglobin/epigallocatechin-3-gallate
(EGCG)
core-shell
nanoparticle-containing
coating
on
stainless
steel
was
prepared
for
CO
loading
modulation.
Inspired
strong
coordination
ability
with
CO,
hemoglobin
nanoparticle
first
encapsulated
into
EGCG
metal-phenolic
networks.
A
polydopamine
(PDA)
linking
layer
then
coated
316
steel,
hemoglobin/EGCG
nanoparticles
were
loaded
subsequent
PDA
deposition.
It
showed
that
maximum
release
amount
17.0
nmol/cm2
in
48
h.
vitro
evaluations
conducted
a
simulated
environment
revealed
coating,
which
released
from
nanoparticles,
effectively
mitigated
lipopolysaccharide-induced
response
macrophages.
Specifically,
it
decreased
expression
tumor
necrosis
factor-α,
increased
interleukin-10,
suppressed
polarization
macrophages
toward
M1
phenotype
reduced
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
under
stress
conditions,
apoptosis
endothelial
cells
induced
down-regulated
ROS
levels.
vivo
results
further
confirmed
its
capabilities,
macrophage-mediated
responses
modulated
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(22), С. 10800 - 10826
Опубликована: Янв. 1, 2024
This
review
provides
a
guideline
for
the
rational
design
of
metal–phenolic
network
(MPN)
composites—which
are
fabricated
from
MPN
and
one
or
more
functional
components
(
e.g.
,
drugs,
proteins)—for
various
applications
across
diverse
disciplines.
Angewandte Chemie International Edition,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Infectious
diseases
pose
considerable
challenges
to
public
health,
particularly
with
the
rise
of
multidrug‐resistant
pathogens
that
globally
cause
high
mortality
rates.
These
can
persist
on
surfaces
and
spread
in
healthcare
settings.
Advances
have
been
made
developing
antimicrobial
materials
reduce
transmission
pathogens,
including
composed
naturally
sourced
polyphenols
their
derivatives,
which
exhibit
potency,
broad‐spectrum
activity,
a
lower
likelihood
promoting
resistance.
This
review
provides
an
overview
recent
advances
fabrication
phenolic
biomaterials,
where
natural
compounds
act
as
active
agents
or
encapsulate
other
(e.g.,
metal
ions,
peptides,
biopolymers).
Various
forms
biomaterials
synthesized
through
these
two
strategies,
particles,
capsules,
hydrogels,
coatings,
are
summarized,
focus
application
wound
healing,
bone
repair
regeneration,
oral
coatings
for
medical
devices.
The
potential
advanced
promising
therapeutic
approach
combating
antimicrobial‐resistant
infections
reducing
microbial
transmission.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(23), С. 29844 - 29855
Опубликована: Июнь 3, 2024
Copper
plays
critical
roles
as
a
metal
active
site
cofactor
and
metalloallosteric
signal
for
enzymes
involved
in
cell
proliferation
metabolism,
making
it
an
attractive
target
cancer
therapy.
In
this
study,
we
investigated
the
efficacy
of
polydopamine
nanoparticles
(PDA
NPs),
classically
applied
removal
from
water,
therapeutic
strategy
depleting
intracellular
labile
copper
pools
triple-negative
breast
models
through
metal-chelating
groups
present
on
PDA
surface.
By
using
activity-based
sensing
probe
FCP-1,
could
track
PDA-induced
depletion
while
leaving
total
levels
unchanged
link
to
selective
MDA-MB-231
death.
Further
mechanistic
investigations
revealed
that
NPs
increased
reactive
oxygen
species
(ROS)
levels,
potentially
inactivation
superoxide
dismutase
1
(SOD1),
copper-dependent
antioxidant
enzyme.
Additionally,
were
found
interact
with
mitochondrial
membrane,
resulting
increase
membrane
potential,
which
may
contribute
enhanced
ROS
production.
We
employed
vivo
tumor
model
validate
NPs.
Remarkably,
absence
any
additional
treatment,
presence
alone
led
significant
reduction
volume
by
factor
1.66
after
22
days
growth.
Our
findings
highlight
potential
promising
approach
selectively
targeting
modulating
inducing
oxidative
stress,
leading
growth
inhibition
shown
these
models.
Biosensors,
Год журнала:
2024,
Номер
14(8), С. 407 - 407
Опубликована: Авг. 22, 2024
Challenges
in
directed
differentiation
and
survival
limit
the
clinical
use
of
stem
cells
despite
their
promising
therapeutic
potential
regenerative
medicine.
Nanotechnology
has
emerged
as
a
powerful
tool
to
address
these
challenges
enable
precise
control
over
cell
fate.
In
particular,
nanomaterials
can
mimic
an
extracellular
matrix
provide
specific
cues
guide
proliferation
field
nanotechnology.
For
instance,
recent
studies
have
demonstrated
that
nanostructured
surfaces
scaffolds
enhance
lineage
commitment
modulated
by
intracellular
regulation
external
stimulation,
such
reactive
oxygen
species
(ROS)
scavenging,
autophagy,
or
electrical
stimulation.
Furthermore,
nanoframework-based
upconversion
nanoparticles
be
used
deliver
bioactive
molecules,
growth
factors,
genetic
materials
facilitate
tissue
regeneration.
The
increasing
nanostructures
research
led
development
new
approaches.
Therefore,
this
review
provides
overview
advances
for
modulating
differentiation,
including
metal-,
carbon-,
peptide-based
strategies.
addition,
we
highlight
nano-enabled
technologies
applications
therapy
focusing
on
improving
efficiency
therapeutics.
We
believe
will
inspire
researchers
intensify
efforts
deepen
understanding,
thereby
accelerating
modulation,
pharmaceutical
industry,
Angewandte Chemie,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Infectious
diseases
pose
considerable
challenges
to
public
health,
particularly
with
the
rise
of
multidrug‐resistant
pathogens
that
globally
cause
high
mortality
rates.
These
can
persist
on
surfaces
and
spread
in
healthcare
settings.
Advances
have
been
made
developing
antimicrobial
materials
reduce
transmission
pathogens,
including
composed
naturally
sourced
polyphenols
their
derivatives,
which
exhibit
potency,
broad‐spectrum
activity,
a
lower
likelihood
promoting
resistance.
This
review
provides
an
overview
recent
advances
fabrication
phenolic
biomaterials,
where
natural
compounds
act
as
active
agents
or
encapsulate
other
(e.g.,
metal
ions,
peptides,
biopolymers).
Various
forms
biomaterials
synthesized
through
these
two
strategies,
particles,
capsules,
hydrogels,
coatings,
are
summarized,
focus
application
wound
healing,
bone
repair
regeneration,
oral
coatings
for
medical
devices.
The
potential
advanced
promising
therapeutic
approach
combating
antimicrobial‐resistant
infections
reducing
microbial
transmission.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 2, 2025
Diabetic
foot
ulcer
is
a
common
and
serious
complication
of
diabetes,
with
high
risk
amputation,
recurrence,
mortality.
Aiming
at
the
characteristics
diabetic
wounds
based
on
result
network
pharmacology,
tailored
ligand
cyanidin-3-O-glucoside
(C3G)
was
selected
to
construct
metal-phenolic
(CM)
through
self-assembly
reaction
manganese
ions.
CM
integrates
pharmacological
advantages
C3G
in
antidiabetes
anti-inflammatory
activity
networks
by
simulating
metal
coordination
structure
antioxidant
enzymes.
Reasonably,
wound
areas
db/db
mice
treatment
rapidly
decreased
3.06%
day
14,
accompanied
improvement
tissue
microenvironment.
Mechanism
investigation
indicated
that
can
not
only
reduce
inflammation
activation
immunoreaction
but
also
increase
gene
transcripts
glucose
metabolism,
response
hypoxia,
angiogenesis.
It
believed
this
work
opens
way
for
designing
disease-specific
networks,
biosafety
promotes
clinical
wounds.
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Март 5, 2025
Periodontitis
is
a
chronic
inflammatory
disease
induced
by
the
microbiome,
leading
to
destruction
of
periodontal
structures
and
potentially
resulting
in
tooth
loss.
Using
local
drug
delivery
systems
as
an
adjunctive
therapy
scaling
root
planning
periodontitis
promising
strategy.
However,
this
administration
method's
effectiveness
constrained
complexity
environment.
Nanomaterials
have
demonstrated
significant
potential
antibacterial
treatment
periodontitis,
attributed
their
controllable
size,
shape,
surface
charge,
high
design
flexibility,
reactivity,
specific
area.
In
review,
we
summarize
complex
microenvironment
difficulties
explicitly
reviewing
application
strategies
nanomaterials
with
unique
properties
distinct
periodontitis.
Furthermore,
review
discusses
limitations
current
research,
proposes
feasible
solutions,
explores
prospects
for
using
context.
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 26, 2025
The
overuse
of
antibiotics
has
increased
the
prevalence
drug-resistant
bacteria
in
periodontitis.
"Sentinel"
gingival
fibroblasts,
stimulated
by
pathogenic
bacteria,
continue
to
release
signaling
factors
that
affect
stem
cell
repair
and
recruit
immune
cells,
resulting
persistent
inflammation
periodontal
tissues,
eventually
leading
loosening
loss
teeth.
Periodontal
cause
surface
hypoxia,
fibroblasts
inflammatory
microenvironment
express
HIF-1α,
promoting
hypoxic
areas
pockets.
No
drug
delivery
system
is
available
for
region
We
synthesized
BI
NPs
via
berberine
(BBR)
indocyanine
green
(ICG)
formed
BIP
wrapping
with
polydopamine
(PDA),
were
delivered
pocket
hitchhiking
anaerobic
probiotic
Bifidobacterium
bifidum
(Bif).
released
berberin
under
near-infrared
(NIR)
irradiation,
which
inhibited
sulfur
metabolism
Porphyromonas
gingivalis
mild
photothermal
action
BBR-targeted
serine
acetyltransferase,
a
decrease
resistance
oxidative
stress,
thus
exerting
nonantibiotic
bacteriostatic
effect.
This
effect
facilitated
uptake
bygingival
fibroblasts.
Moreover,
BBR
targeted
nuclear
factor-erythroid
2-related
factor
2
(NRF2)
reduce
ferroptosis,
fibroblast
supernatant
modulated
macrophage
polarization
through
NF-κB
pathway.
In
periodontitis
rat
model,
Bif@BIP+NIR
treatment
carried
deep
pockets,
decreasing
local
ferroptosis
alleviating
symptoms.
To
summarize,
engineered
probiotics
target
low-oxygen
pockets
delivery,
P.
bacterial
inhibition,
mitigate
