MRS Advances, Год журнала: 2024, Номер unknown
Опубликована: Дек. 19, 2024
Язык: Английский
Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 98 - 98
Опубликована: Янв. 13, 2025
The application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially promoting healing and regeneration. With a deeper understanding the mechanisms defects disorders, LRNs are receiving increasing attention due to their non-invasive, controllable, efficient properties. These materials can regulate cellular biological reactions promote cell adhesion, proliferation, differentiation by absorbing specific wavelengths light converting them into physical chemical signals. In addition, unique surface morphology biocompatibility enable effectively load drugs engineering, achieve precise release, optimize regeneration process. Through photothermal photodynamic therapy, these also possess antibacterial properties play an important role repair infectious defects. Although have shown significant advantages regeneration, series challenges still need be overcome widespread effective clinical applications. This article summarizes basic principles, classification, potential applications aiming provide reference for future research
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(3), С. 190 - 190
Опубликована: Март 8, 2025
In recent years, hydrogels have emerged as promising candidates for bone defect repair due to their excellent biocompatibility, high porosity, and water-retentive properties. However, conventional face significant challenges in clinical translation, including brittleness, low mechanical strength, poorly controlled drug degradation rates. To address these limitations, a multifunctional polymer, polydopamine (PDA) has shown great potential both regeneration delivery systems. Its robust adhesive properties, responsiveness photothermal stimulation make it an ideal candidate enhancing hydrogel performance. Integrating PDA into not only improves properties but also creates environment conducive cell adhesion, proliferation, differentiation, thereby promoting repair. Moreover, facilitates release, offering approach optimizing treatment outcomes. This paper first explores the mechanisms through which promotes regeneration, laying foundation its translation. Additionally, discusses application of PDA-based nanocomposite advanced systems repair, providing valuable insights research
Язык: Английский
Процитировано
0
Materials & Design, Год журнала: 2025, Номер unknown, С. 113967 - 113967
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Surfaces and Interfaces, Год журнала: 2025, Номер 66, С. 106601 - 106601
Опубликована: Апрель 30, 2025
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Injectable hydrogels with self-healing properties, tissue adhesion, biocompatibility, and cancer therapeutic capabilities offer a promising solution for addressing bone loss residual tumor cells following surgical resection of osteosarcoma. In this study, injectable adhesive hybrid were developed using natural silk-derived proteins, silk fibroin (SF), sericin (SS). The was surface functionalized dopamine (DOPA) forming SSDOPA, while the enzymatically oxidized (forming SFO) to introduce abundant catechol moieties on polymer chains. These modifications enabled hydrogelation self-assembly in presence copper ions (Cu2+) tannic acid (TA), creating an SFO-SSDopa-Cu2+-TA hydrogel inspired by mussel adhesion mechanism. dynamic metal-catechol coordination bonds, along other covalent non-covalent interactions gel network, imparted excellent shear-thinning properties 3D printability, injectability, (72.27 ± 9.35% after 6 cyclic), making it suitable minimally invasive surgeries targeted delivery applications. Additionally, demonstrated strong adhesiveness (664.03 15.87 kPa 854.15 12.90 Gel- Hap-based substrates respectively), showing bonding performance tissue. Its black coloration efficient absorption near-infrared (NIR) light (reach 45-48 °C), facilitating eradication almost 60% osteosarcoma through photothermal therapy within 20 minutes irradiation laser. Moreover, promoted proliferation migration pre-osteoblast cells, confirming their biocompatibility. Coupled good biodegradability, these demonstrate significant potential as theragenerative materials treatment, providing clinically translatable repairing affected disease.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Май 9, 2025
Silk fibroin (SF), derived from silk cocoon fibers (Bombyx mori), is a natural protein polymer known for its biocompatibility, biodegradability, and sustainability. The can be processed into various material formats suitable range of applications. Among these, SF hydrogels are useful in the biomedical field, such as tissue engineering, due to tailorable structures properties achievable through tuning gelation process. Therefore, focus this contribution comprehensively review understand formation, mechanism, dynamic control, functionalization hydrogels. Unlike previous reviews, work delves understanding strategies mechanisms dynamics molecular assembly crystallization points view. Further, presents pathways practical examples, 3D printing hydrogels, illustrate how these strategies, mechanisms, implemented specific application scenario. With insights, researchers gain deeper manipulate or control process types achieve features. This knowledge would further facilitate development hydrogel materials fields.
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 541, С. 216801 - 216801
Опубликована: Май 17, 2025
Язык: Английский
Процитировано
0
MRS Communications, Год журнала: 2025, Номер unknown
Опубликована: Май 30, 2025
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 542, С. 216868 - 216868
Опубликована: Июнь 6, 2025
Язык: Английский
Процитировано
0