Analytical Chemistry,
Год журнала:
2024,
Номер
96(44), С. 17781 - 17788
Опубликована: Окт. 22, 2024
Point-of-care
(POC)
tests
increasingly
highlight
the
importance
of
portable,
cost-effective,
and
visually
quantitative
detection
biomarkers.
Herein,
we
developed
a
power-free
visual
signal-readout
POC
sensor
based
on
target-triggered
ultrafast
gelation
process.
In
process,
target
triggered
cascade
reaction
catalyzed
by
oxidase
ferrous
glycinate
to
produce
carbon
radicals
that
immediately
initiated
rapid
polymerization
cross-linking
acryloylated
chondroitin
sulfate
dimethylacrylamide.
This
highly
efficient
enzymatic
process
contributed
generation
hydrogel
within
1
min
at
25
°C.
The
increase
in
viscosity
aqueous
solution
resulted
from
formation
was
then
measured
according
distance
migration
tick-labeled
pH
test
strip,
which
thus
realized
quantification
target.
By
utilizing
glucose
as
an
model
during
this
successfully
employed
without
need
for
any
auxiliary
instruments.
Benefiting
specificity
stability
reaction,
exhibited
excellent
performance
clinical
blood
samples.
Moreover,
further
extended
uric
acid
enabled
accurate
assay
urine
samples,
indicated
versatility
practicability
test.
This
review
summarizes
the
fundamental
concepts,
recent
advancements,
and
emerging
trends
in
field
of
stimuli-responsive
hydrogels.
While
numerous
reviews
exist
on
this
topic,
continues
to
evolve
dynamically,
certain
research
directions
are
often
overlooked.
To
address
this,
we
classify
hydrogels
based
their
response
mechanisms
provide
an
in-depth
discussion
key
properties
mechanisms,
including
swelling
kinetics,
mechanical
properties,
biocompatibility/biodegradability.
We
then
explore
hydrogel
design,
synthesis,
structural
engineering,
followed
by
overview
applications
that
relatively
well
established
from
a
scientific
perspective,
biomedical
uses
(biosensing,
drug
delivery,
wound
healing,
tissue
engineering),
environmental
(heavy
metal
phosphate
removal
environment
polluted
water),
soft
robotics
actuation.
Additionally,
highlight
unconventional
such
as
local
micro-thermometers
cell
mechanotransduction.
concludes
with
current
challenges
future
prospects
field,
aiming
inspire
further
innovations
advancements
bring
them
closer
societal
needs.
ABSTRACT
Flexible
sensors
exhibit
the
properties
of
excellent
shape
adaptability
and
deformation
ability,
which
have
been
applied
for
environmental
monitoring,
medical
diagnostics,
food
safety,
smart
systems,
human–computer
interaction.
Cellulose‐based
hydrogels
are
ideal
materials
fabrication
flexible
due
to
their
unique
three‐dimensional
structure,
renewability,
ease
processing,
biodegradability,
modifiability,
good
mechanical
properties.
This
paper
comprehensively
reviews
recent
advances
cellulose‐based
in
construction
sensor
applications.
The
characteristics,
mechanisms,
advantages
prepared
by
physical
cross‐linking,
chemical
cross‐linking
respectively
analyzed
summarized
detail.
focus
then
turns
research
development
hydrogel
sensors,
including
sensing
(pressure/strain,
humidity/temperature,
optical
sensing),
(chromium,
copper,
mercury
ion
sensing,
toxic
gas
nitrite
biosensing
(glucose,
antibody,
cellular
sensing).
Additionally,
limitations
along
with
key
challenges
future
directions,
discussed.
It
is
anticipated
that
this
review
will
furnish
invaluable
insight
advancement
novel
green,
facilitate
integration
as
a
fundamental
component
multifunctional
technologies,
thereby
expediting
design
innovative
near
future.
Biosensors,
Год журнала:
2025,
Номер
15(2), С. 119 - 119
Опубликована: Фев. 18, 2025
This
review
into
recent
advancements
in
silicon-based
technology,
with
a
particular
emphasis
on
the
biomedical
applications
of
silicon
sensors.
Owing
to
their
diminutive
size,
high
sensitivity,
and
intrinsic
compatibility
electronic
systems,
sensors
have
found
widespread
utilization
across
healthcare,
industrial,
environmental
monitoring
domains.
In
realm
sensing,
has
demonstrated
significant
potential
enhance
human
health
outcomes
while
simultaneously
driving
progress
microfabrication
techniques
for
multifunctional
device
development.
The
systematically
examines
versatile
roles
fabrication
electrodes,
sensing
channels,
substrates.
Silicon
electrodes
are
widely
used
electrochemical
biosensors
glucose
neural
activity
recording,
channels
field-effect
transistor
enable
detection
cancer
biomarkers
small
molecules.
Porous
substrates
applied
optical
label-free
protein
pathogen
detection.
Key
challenges
this
field,
including
interaction
biomolecules,
economic
barriers
miniaturization,
issues
related
signal
stability,
critically
analyzed.
Proposed
strategies
address
these
improve
sensor
functionality
reliability
also
discussed.
Furthermore,
article
explores
emerging
developments
biosensors,
particularly
integration
wearable
technologies.
pivotal
role
artificial
intelligence
(AI)
enhancing
performance,
functionality,
real-time
capabilities
is
highlighted.
provides
comprehensive
overview
current
state,
challenges,
future
directions
field
ACS Omega,
Год журнала:
2025,
Номер
10(9), С. 8816 - 8831
Опубликована: Март 3, 2025
Early
diagnosis
of
cancer
can
significantly
contribute
to
improving
therapeutic
outcomes
and
enhancing
survival
rates
for
patients.
Polymer-based
biosensors
have
emerged
as
a
promising
tool
detection
due
their
high
sensitivity,
selectivity,
low
cost.
These
utilize
functionalized
polymers
in
different
parts
the
body
detect
biomarkers
biological
samples.
This
approach
offers
several
advantages
over
traditional
methods,
including
real-time
monitoring
noninvasive
while
maintaining
sensitivity
accuracy.
review
discusses
recent
advances
development
polymer-based
design,
fabrication,
performance.
The
essential
characteristics
biosensing
devices
are
presented,
along
with
examples
natural
synthetic
commonly
utilized
biosensors.
Furthermore,
strategies
employed
tailor
improve
applications
future
perspectives
application
also
highlighted.
Integrating
these
advancements
will
illuminate
potential
transformative
tools
early
management
cancer.
Bioengineering,
Год журнала:
2025,
Номер
12(3), С. 254 - 254
Опубликована: Март 3, 2025
Pancreatitis
is
a
prominent
and
severe
type
of
inflammatory
disorder
that
has
grabbed
lot
scientific
clinical
interest
to
prevent
its
onset.
It
should
be
detected
early
avoid
the
development
serious
complications,
which
occur
due
long-term
damage
pancreas.
The
accurate
measurement
biomarkers
are
released
from
pancreas
during
inflammation
essential
for
detection
treatment
patients
with
acute
chronic
pancreatitis,
but
this
sub-optimally
performed
in
clinically
relevant
practices,
mainly
complexity
procedure
cost
treatment.
Clinically
available
tests
pancreatitis
often
time-consuming.
also
relates
disorders
exocrine
pancreas,
such
as
cystic
fibrosis
hereditary
form
fibrosis-like
syndrome
acquired
genetic
symptoms
can
correlated
overexpression
specific
markers
creatinine
biological
fluids
like
urine.
In
review,
we
studied
how
develop
minimally
invasive
system
using
hydrogel-based
biosensors,
highly
absorbent
biocompatible
polymers
respond
stimuli
enzymes,
pH,
temperature,
or
presence
biomarkers.
These
biosensors
helpful
real-time
health
monitoring
medical
diagnostics
since
they
translate
reactions
into
quantifiable
data.
This
paper
sheds
light
on
possible
use
Ayurvedic
formulations
along
hydrogels
strategy.
analytical
devices
used
enhance
real
time.
Chemosensors,
Год журнала:
2025,
Номер
13(3), С. 92 - 92
Опубликована: Март 5, 2025
Nonspecific
adsorption
(NSA)
impacts
the
performance
of
biosensors
in
complex
samples.
Coupled
electrochemical–surface
plasmon
resonance
(EC-SPR)
offer
interesting
opportunities
to
evaluate
NSA.
This
review
details
main
solutions
minimize
fouling
electrochemical
(EC),
surface
(SPR)
and
EC-SPR
biosensors.
The
discussion
was
centered
on
blood,
serum
milk
as
examples
matrices.
Emphasis
placed
antifouling
coatings,
NSA
evaluation
protocols
universal
functionalization
strategies
obtain
In
last
5
years,
various
coatings
were
developed
for
EC
biosensors,
including
new
peptides,
cross-linked
protein
films
hybrid
materials.
Due
comparatively
much
more
scarce
literature,
SPR
extended
early
2010s.
analysis
revealed
a
wide
range
materials
with
tunable
conductivity,
thickness
functional
groups
that
can
be
tested
future
EC-SPR.
high-throughput
screening
materials,
molecular
simulations
machine
learning-assisted
evaluations
will
even
further
widen
available
minimization
NSA’s
impact
analytical
signal
is
moreover
facilitated
by
unique
sensing
mechanisms
associated
bioreceptor
or
particularities
detection
method.
It
hoped
this
encourage
research
field
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125640 - 125640
Опубликована: Апрель 1, 2025
Multiple
chemotherapeutic
strategies
have
been
developed
to
tackle
the
complexity
of
cancer.
Still,
outcome
regimens
remains
impaired
by
drugs'
weak
solubility,
unspecific
biodistribution
and
poor
tumor
accumulation
after
systemic
administration.
Such
constraints
triggered
development
nanomaterials
encapsulate
deliver
anticancer
drugs.
In
fact,
loading
drugs
into
nanoparticles
can
overcome
most
solubility
concerns.
However,
ability
systemically
administered
drug-loaded
reach
site
has
vastly
overestimated,
limiting
their
clinical
translation.
The
nanomaterials'
administration
issues
propelled
hydrogels
capable
performing
direct/local
delivery
site.
use
these
macroscale
systems
mediate
a
tumor-confined
drugs/drugs-loaded
grants
an
improved
therapeutic
efficacy
and,
simultaneously,
reduction
side
effects.
manufacture
requires
careful
selection
tailoring
specific
polymers/materials
as
well
choice
appropriate
physical
and/or
chemical
crosslinking
interactions.
Depending
on
route
assembling
process,
matrices
be
classified
injectable
in
situ
forming
hydrogels,
shear-thinning/self-healing
implantable
each
type
bringing
plethora
advantages
for
intended
biomedical
application.
This
review
provides
reader
with
insight
application
nanomaterials.
