Fe₃O₄-Based Nanospheres with High Photothermal Conversion Efficiency for Dual-Effect and Mild Biofilm Eradication against Periodontitis

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

Periodontitis, a chronic inflammatory oral disease resulting from plaque biofilms, affects about 743 million individuals worldwide. However, the efficacy of current treatments is hampered by challenges in delivering antibiotics to recalcitrant biofilms and bacterial resistance, thereby impeding successful treatment infectious diseases. To address issues, an antibacterial photothermal material was designed, comprising spherical structure zinc oxide (ZnO) wrapped with triiron tetraoxide (Fe3O4). The outer layer adsorbed epsilon-polylysine (EPL) electrostatic action, ultimately leading fabrication Fe3O4/ZnO/EPL nanoparticles (FZE NPs). Fe3O4 core endowed efficient properties, facilitating dispersion dense which dramatically promoted adsorption penetration ZnO EPL into effectively kill bacteria vitro enhanced sterilization ability. Additionally, upon dissolution aqueous media, acts as positively charged antimicrobial peptide that adsorbs onto surface negatively membranes, modulating responses. In order ascertain FZE NPs, investigation conducted their effects against periodontitis-associated pathogen Porphyromonas gingivalis (P. gingivalis) vitro. Furthermore, antiperiodontitis potential NPs evaluated Sprague-Dawley (SD) rats ligamentous periodontitis. addition, toxicity evaluations indicated had acceptable biosafety profile vivo. summary, nanospheres NPs) represent promising therapeutic strategy for

Язык: Английский

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NIR-Absorbing Tetraphenylethene-Containing bisBODIPY Nanoplatforms Demonstrate Effective Lysosome-Targeting and Combinational Phototherapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(32), С. 41916 - 41926

Опубликована: Июль 31, 2024

Photosensitizer-based phototherapies, including photodynamic therapy (PDT) and photothermal (PTT), offer safe treatment modalities for tumor ablation with spatiotemporal precision. After photons are absorbed, PDT creates localized chemical damage by generating reactive oxygen species (ROS), while PTT induces thermal damage. However, still faces hypoxic challenges, encounters issues related to heat resistance potential overheating. The combination of shows great as an effective anticancer strategy. By targeting lysosomes carefully designed phototherapeutic reagents combined phototherapy, rapid dysfunction cell death in cancer cells can be induced, showing promise treatment. Herein, two α–α-linked bisBODIPYs tetraphenylethene (TPE) moieties synthesized. These TPE-substituted expand the absorption into NIR range (λmaxabs/λmaxem ∼ 740/810 nm) confer aggregation-induced emission (AIE) activity (λmaxem 912 nm). Moreover, these self-assemble surfactant F-127 nanoparticles (NPs), which efficiently generate ROS (1O2 •OH) both solution cellular environments demonstrate superior conversion efficiencies (η 68.3%) along exceptional stability. More importantly, NPs showed lysosomal remarkable murine models, indicating their precision therapy.

Язык: Английский

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Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential improving cancer immunotherapy by altering tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate system to specifically recognize destroy cells. Combined immunotherapeutic agents, can amplify anti-cancer integrating remodeling immunogenic cell death (ICD). This review offers a thorough discussion about various involved immunity, including those mimicking catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), oxidase (OXD). It also discusses challenges future directions for translating nanozyme platforms into clinical applications, enhancing susceptibility cells immunotherapy. Nanozyme-based strategies substantial oncology, offering new effective options management.

Язык: Английский

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Construction of pH-Responsive Copper Sulfide Nanocomposites and Their Photothermal/Chemodynamic Synergistic Antibacterial Studies

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

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Recent trends and perspectives in rhenium-based nanomaterials for sustainable applications

Coordination Chemistry Reviews, Год журнала: 2024, Номер 527, С. 216382 - 216382

Опубликована: Дек. 18, 2024

Язык: Английский

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