Materials Letters, Год журнала: 2024, Номер unknown, С. 137721 - 137721
Опубликована: Ноя. 1, 2024
Язык: Английский
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 11, 2025
Sonodynamic therapy (SDT) is a noninvasive approach to tumor treatment, with ongoing efforts being focused on developing highly effective sonosensitizers low toxicity. Herein, liquid-phase stripping technique was introduced as simple reflux method for synthesizing ultrasmall Mn-PCN-224 nanodots (MM NDs). Compared PCN-224 nanodots, the synthesized MM NDs, which function renal-clearable nanoagents, produced 2.42 times more reactive oxygen species (ROS) under identical ultrasound (US) irradiation conditions. In vivo and in vitro experiments revealed that A549 lung cancer cells treated NDs US H2O2 exhibited relative cell viability of ∼9% inhibition rate ∼91%. This result demonstrates can efficiently increase effectiveness SDT by leveraging their catalase-like activity size (4 nm) prevent ROS quenching. Furthermore, these nanoagents could be effectively utilized photoacoustic (PA) imaging track accumulation tumors monitor alleviation hypoxic microenvironment. Notably, ND-mediated demonstrated superior penetration depth compared PDT, making it inhibiting contralateral while facilitating deep-tissue treatment. Thus, this study introduces promising potential PA-guided SDT, thereby paving way treatment strategies.
Язык: Английский
Процитировано
1
APL Materials, Год журнала: 2024, Номер 12(8)
Опубликована: Авг. 1, 2024
MXenes, a novel class of two-dimensional (2D) materials, have attracted considerable attention in various fields, especially drug delivery, wound healing, bone tissue engineering, biosensing, and cancer treatment. Thanks to their remarkable physicochemical properties, MXenes hold great promise for biomedical applications. Concurrently, hydrogels composed polymers been extensively utilized contexts. The unique properties facilitate integration into bioactive with enhanced functions thereby endowing the composites multifunctional capabilities. MXene-reinforced polymer (MRPHs) synergistically combine advantageous characteristics both hydrogels, making them highly adaptable other theranostic strategies medical In this comprehensive review, we demonstrate recent advances design synthesis MRPHs Specifically, introduce analyze methods tailoring by incorporating active components, including functional molecules, 2D metal ions, natural polymers, drugs/genes. We then discuss applications designed biosensors, therapy. hope that work provides valuable guidance inspiration readers develop advanced
Язык: Английский
Процитировано
5
Biomedical Technology, Год журнала: 2025, Номер 9, С. 100070 - 100070
Опубликована: Фев. 14, 2025
Язык: Английский
Процитировано
0
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.
Язык: Английский
Процитировано
0
BME Frontiers, Год журнала: 2024, Номер 5
Опубликована: Янв. 1, 2024
Sonodynamic therapy (SDT) has emerged as a novel and highly researched advancement in the medical field. Traditional ultrasound contrast agents bubble-shaped are used to stimulate cavitation enhance SDT efficiency. However, impact of artificially modified shell structures on acoustic properties microbubbles remains be explored. Alternatively, absence agents, some clinically available organic sonosensitizers advanced inorganic materials also efficacy SDT. Diagnostic therapeutic can activate bubbles, which supply energy sonosensitive leading production cytotoxic free radicals achieve effects. While often spark controversy clinical applications, their relatively simple structure enables researchers gain insight into mechanism by produces various radicals. Some organic–inorganic hybrid systems have been reported, combining benefits agents. employing cell surface modification engineering enable cells perform functions such immune escape, drug loading, gas sonosensitivity, cellular developed. further exploration is needed properties, ability generate reactive oxygen species (ROS), potential application this sonosensitizer. This review offers comprehensive analysis vesical nanoscale sonocatalysts, including organic, inorganic, combined sonosensitizers, sonosensitizers. will our understanding demonstrate its important transforming applications.
Язык: Английский
Процитировано
1
Materials Letters, Год журнала: 2024, Номер unknown, С. 137721 - 137721
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0