Cited by Highly Efficient Thiol-Michael Addition Post-Modification toward Potent Degradable Antibacterial Polyesters with Guanidine Moiety

Highly Efficient Thiol-Michael Addition Post-Modification toward Potent Degradable Antibacterial Polyesters with Guanidine Moiety DOI

и другие.

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

We have previously synthesized poly(3-methylene-1,5-dioxepan-2-one) (PMDXO) that could be modified through the thiol-Michael addition reaction to afford versatile degradable polymers. Herein, we find γ-oxa in PMDXO exerts a dramatically accelerating effect on post-modification, which makes promising platform polymer for synthesizing guanidinium-functionalized aliphatic polyesters under mild and approximately stoichiometric conditions. The relationship between structure antibacterial performance was investigated. A cationic polyester, P20-2C, shows extremely low hemolytic activity, moderate cytotoxicity, broad-spectrum potent bactericidal capability against 214 clinically isolated ESKAPE strains, is obtained. good biocompatibility vivo efficacy of P20-2C been demonstrated mice using three bacterial infection models, including MDR E. coli-infected peritonitis MRSA-infected subcutaneous abscess skin wound. Finally, multimodal mechanism membrane disruption plus reactive oxygen species upregulation proposed coli S. aureus.

Язык: Английский

Antimicrobial Silicon Rubber Crosslinked with Bornyl‐Siloxane DOI

Chen Chen, Songtao Wang, Xinyu Chen

и другие.

Macromolecular Rapid Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract Silicone rubber (SiR) has a wide range of medical applications, but it lacks antimicrobial properties, leading to potential infection issues with related implants or devices. Most studies focus on adding anti‐bacterial agents surface modification, which usually result in composites rather than synthesizing SiR intrinsically performances. To tackle this issue, double substituted bornyl‐siloxane crosslinker (BC) is designed. This can react hydroxy‐terminated polydimethylsiloxane (PDMS) at room temperature yield borneol side groups. The process simple without using additional solvents. Antimicrobial assay cured different ratios BC/PDMS showed that 20 wt.% BC cross‐linked network exhibited outstanding adhesion ( Escherichia coli 99.4%, Staphylococcus aureus 97.3%) performance and long‐lasting anti‐mold Aspergillus niger over 99% for 30 days) properties. Moreover, the subcutaneous implantation model mice demonstrated its excellent anti‐infection, biocompatibility safety. Therefore, material promising widespread adoption field, especially silicon‐based products coatings.

Язык: Английский

Процитировано

Highly Efficient Antimicrobial Coated Surfaces with Copolymers of Guanylated-And Natural Product Derived Monomers DOI