Modulation of β secretase and neuroinflammation by biomimetic nanodelivery system for Alzheimer's disease therapy DOI
Xiaolei Song,

Chenchen Wang,

Qin Ding

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 378, С. 735 - 749

Опубликована: Дек. 28, 2024

Язык: Английский

Nanoscale drug formulations for the treatment of Alzheimer's disease progression DOI Creative Commons

Liu Liqin,

Haini He,

Bert N. La Du

и другие.

RSC Advances, Год журнала: 2025, Номер 15(6), С. 4031 - 4078

Опубликована: Янв. 1, 2025

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective disease-modifying treatments.

Язык: Английский

Процитировано

2

Recent Progress in Nanomedicine for the Diagnosis and Treatment of Alzheimer’s Diseases DOI

Han Yang,

Haozhe Tan,

Haifei Wen

и другие.

ACS Nano, Год журнала: 2024, Номер 18(50), С. 33792 - 33826

Опубликована: Дек. 3, 2024

Alzheimer's disease (AD) is a neurodegenerative that causes memory loss and progressive permanent deterioration of cognitive function. The most challenging issue in combating AD its complicated pathogenesis, which includes the deposition amyloid β (Aβ) plaques, intracellular hyperphosphorylated tau protein, neurofibrillary tangles (NFT), etc. Despite rapid advancements mechanistic research drug development for AD, currently developed drugs only improve ability temporarily relieve symptoms but cannot prevent AD. Moreover, blood–brain barrier (BBB) creates huge to delivery brain. Therefore, effective diagnostic tools treatments are urgently needed. In recent years, nanomedicine has provided opportunities overcome challenges limitations associated with traditional diagnostics or treatments. Various types nanoparticles (NPs) play an essential role diagnosis treatment acting as carriers targeting bioavailability across/bypass BBB directly on lesions. This review categorizes different NPs summarizes their applications It also discusses clinical explores latest developments prospects

Язык: Английский

Процитировано

6

Stimuli‐Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases DOI Open Access
Xi‐jian Dai, Weilong Li, Dongdong Xie

и другие.

Small, Год журнала: 2025, Номер 21(9)

Опубликована: Янв. 22, 2025

Abstract Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which focus research. Stimulus‐responsive nanodrug delivery systems (SRDDS) stand out as sophisticated class nanocarriers that release drugs response to environmental cues. Due complex pathogenesis multifaceted pathological environment nervous system, developing accurate effective drug therapy low side‐effects is formidable task. In recent years, SRDDS been widely used treatment neurological diseases. By customizing align specific microenvironment system tissues or external stimulation, efficacy enhanced. This review provides an in‐depth look at characteristics diseases highlights case studies tailored treat these disorders based on unique stimulation criteria triggers. Additionally, this comprehensive overview progress future prospects technology diseases, providing valuable guidance for its transition from fundamental research clinical application.

Язык: Английский

Процитировано

0

NIR-Responsive Functionalized Nanoflower for Acute Spinal Cord Injury DOI
Wenjuan Wang,

Haosen Zhao,

Hongkai Yang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Excessive accumulations of reactive oxygen species (ROS) and M1 macrophages are closely associated with the complex pathogenesis spinal cord injury (SCI). Thus, therapeutics that synergistically exert elimination ROS repolarization pro-inflammation gaining increasing notice. We developed a prussian blue-based nanoflower (KPBF) near-infrared (NIR) photothermal antioxidant properties. The KPBF's biofunctions were similar to those other enzymes, such as catalase superoxide dismutase, which capable reducing ROS. With NIR irradiation, KPBF efficiently heated injured lesion. By modifying CKLVFFAED peptide, remarkably penetrated through blood–spinal barrier (BSCB) into local Moreover, repolarized alleviated neuroinflammation in SCI mice. Overall, presented universal nanotherapeutic system immunoregulation activities for acute recovery.

Язык: Английский

Процитировано

0

Natural Bioactive Compounds Solanesol and Chlorogenic Acid Assembled Nanomicelles for Alzheimer’s Disease Therapy DOI
Chenchen Wang, Xiaowan Zhang,

Yurong Zhuang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Solanesol (Sol) and chlorogenic acid (CHA) are naturally active compounds. Sol exhibits a significant free radical absorption ability strong antioxidant activity. CHA, typical phenolic acid, excellent anticancer, anti-inflammation, antibacterial properties. Herein, bifunctional nanomicelles (CI@SPK) were skillfully designed to take advantage of the unique properties CHA treat Alzheimer's disease (AD). Hydrophobic was modified with poly(ethylene glycol) self-assemble into stable (SP). could be encapsulated hydrophobic core these nanomicelles, which increased its bioavailability greatly. Short peptide K (CKLVFFAED) incorporated facilitate their crossing blood-brain barrier. Then, CI@SPK targeted AD lesion area, released in greater quantities help IR780 under irradiation an 808 nm laser, resulting synergistically scavenging reactive oxygen species (ROS) Sol. Consequently, demonstrated capabilities ROS, inhibiting β-amyloid (Aβ) aggregation, eventually modulating microglia phenotype from M1 M2 promote Aβ phagocytosis clearance. In vivo studies indicated that improved learning cognitive impairments APP/PS1 mice by reducing plaque inflammation, signifying potential value clinical application for treatment.

Язык: Английский

Процитировано

0

IR780-Based Nanotheranostics and In Vivo Effects: A Review DOI Creative Commons
Márcia Célia Pacheco Fialho, Maria Alice de Oliveira, Marina Guimarães Carvalho Machado

и другие.

Journal of Nanotheranostics, Год журнала: 2025, Номер 6(1), С. 8 - 8

Опубликована: Март 7, 2025

Photodynamic and photothermal therapies with IR780 have gained exponential interest, their photophysical properties demonstrated promise for use in antitumor antimicrobial chemotherapy. its derivatives are valuable labeling nanostructures different chemical compositions vitro vivo fluorescence monitoring studies the near-infrared (NIR) spectrum. The current literature is abundant on this topic, particularly applications treatment of types cancer using laser illumination to produce photodynamic (PDT), (PTT), and, more recently, sonodynamic therapy (SDT) approaches cell death. This review aims update state art concerning photosensitizer as a theranostic agent PDT, PTT, SDT, photoacoustic (PA) effects, imaging associated nanocarriers. concerns period from 2017 2024, considering, specifically, effects found preclinical experiments. Some aspects stability nanostructured systems will be discussed based evidence leakage nanocarrier consequences reliable analysis biological data.

Язык: Английский

Процитировано

0

ROS-related nanoparticles for the management of Alzheimer’s disease: Wielding the double-edged sword DOI

Yibin Yu,

Qi Zhang, Yihao Guo

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161784 - 161784

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Advancing Nanomaterial-Based Strategies for Alzheimer’s Disease: A Perspective DOI Creative Commons
Hong Zhou, Xiuhua Yin,

G. Y. Zhang

и другие.

JACS Au, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, number AD cases projected to exceed 131 million, placing significant strain on healthcare systems economies worldwide. The pathogenesis multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, inflammation. Despite extensive research, complexity these potentially entangled mechanisms has hindered development treatments that can reverse progression. Nanotechnology, leveraging unique physical, electrical, magnetic, optical properties nanomaterials, emerged promising approach for treatment. In this Perspective, we first outlined major current pathogenic hypotheses then reviewed recent advances in nanomaterials addressing hypotheses. We have also discussed challenges translating into clinical applications proposed future directions, particularly multifunctional multitarget enhance their therapeutic efficacy applicability

Язык: Английский

Процитировано

0

Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment DOI
Chenchen Wang, Xiaolei Song, Xiaowan Zhang

и другие.

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101841 - 101841

Опубликована: Май 8, 2025

Язык: Английский

Процитировано

0

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics DOI Creative Commons
Jingyu Shi, Yadi Fan, Qin Zhang

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

Abstract The rapidly advancing field of theranostics aims to integrate therapeutic and diagnostic functionalities into a single platform for precision medicine, enabling the simultaneous treatment monitoring diseases. Photo‐energy conversion‐based nanomaterials have emerged as versatile that utilizes unique properties light activate with high spatial temporal precision. This review provides comprehensive overview recent developments in photo‐energy conversion using nanomaterials, highlighting their applications disease theranostics. discussion begins by exploring fundamental principles including types materials used various light‐triggered mechanisms, such photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered SERS, photodynamic processes. Following this, delves broad spectrum emphasizing role diagnosis major diseases, cancer, neurodegenerative disorders, retinal degeneration, osteoarthritis. Finally, challenges opportunities technologies are discussed, aiming advance personalized medicine.

Язык: Английский

Процитировано

0