Journal of Controlled Release, Год журнала: 2024, Номер 378, С. 735 - 749
Опубликована: Дек. 28, 2024
Язык: Английский
RSC Advances, Год журнала: 2025, Номер 15(6), С. 4031 - 4078
Опубликована: Янв. 1, 2025
Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective disease-modifying treatments.
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2024, Номер 18(50), С. 33792 - 33826
Опубликована: Дек. 3, 2024
Alzheimer's disease (AD) is a neurodegenerative that causes memory loss and progressive permanent deterioration of cognitive function. The most challenging issue in combating AD its complicated pathogenesis, which includes the deposition amyloid β (Aβ) plaques, intracellular hyperphosphorylated tau protein, neurofibrillary tangles (NFT), etc. Despite rapid advancements mechanistic research drug development for AD, currently developed drugs only improve ability temporarily relieve symptoms but cannot prevent AD. Moreover, blood–brain barrier (BBB) creates huge to delivery brain. Therefore, effective diagnostic tools treatments are urgently needed. In recent years, nanomedicine has provided opportunities overcome challenges limitations associated with traditional diagnostics or treatments. Various types nanoparticles (NPs) play an essential role diagnosis treatment acting as carriers targeting bioavailability across/bypass BBB directly on lesions. This review categorizes different NPs summarizes their applications It also discusses clinical explores latest developments prospects
Язык: Английский
Процитировано
6
Small, Год журнала: 2025, Номер 21(9)
Опубликована: Янв. 22, 2025
Abstract Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which focus research. Stimulus‐responsive nanodrug delivery systems (SRDDS) stand out as sophisticated class nanocarriers that release drugs response to environmental cues. Due complex pathogenesis multifaceted pathological environment nervous system, developing accurate effective drug therapy low side‐effects is formidable task. In recent years, SRDDS been widely used treatment neurological diseases. By customizing align specific microenvironment system tissues or external stimulation, efficacy enhanced. This review provides an in‐depth look at characteristics diseases highlights case studies tailored treat these disorders based on unique stimulation criteria triggers. Additionally, this comprehensive overview progress future prospects technology diseases, providing valuable guidance for its transition from fundamental research clinical application.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 9, 2025
Excessive accumulations of reactive oxygen species (ROS) and M1 macrophages are closely associated with the complex pathogenesis spinal cord injury (SCI). Thus, therapeutics that synergistically exert elimination ROS repolarization pro-inflammation gaining increasing notice. We developed a prussian blue-based nanoflower (KPBF) near-infrared (NIR) photothermal antioxidant properties. The KPBF's biofunctions were similar to those other enzymes, such as catalase superoxide dismutase, which capable reducing ROS. With NIR irradiation, KPBF efficiently heated injured lesion. By modifying CKLVFFAED peptide, remarkably penetrated through blood–spinal barrier (BSCB) into local Moreover, repolarized alleviated neuroinflammation in SCI mice. Overall, presented universal nanotherapeutic system immunoregulation activities for acute recovery.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Solanesol (Sol) and chlorogenic acid (CHA) are naturally active compounds. Sol exhibits a significant free radical absorption ability strong antioxidant activity. CHA, typical phenolic acid, excellent anticancer, anti-inflammation, antibacterial properties. Herein, bifunctional nanomicelles (CI@SPK) were skillfully designed to take advantage of the unique properties CHA treat Alzheimer's disease (AD). Hydrophobic was modified with poly(ethylene glycol) self-assemble into stable (SP). could be encapsulated hydrophobic core these nanomicelles, which increased its bioavailability greatly. Short peptide K (CKLVFFAED) incorporated facilitate their crossing blood-brain barrier. Then, CI@SPK targeted AD lesion area, released in greater quantities help IR780 under irradiation an 808 nm laser, resulting synergistically scavenging reactive oxygen species (ROS) Sol. Consequently, demonstrated capabilities ROS, inhibiting β-amyloid (Aβ) aggregation, eventually modulating microglia phenotype from M1 M2 promote Aβ phagocytosis clearance. In vivo studies indicated that improved learning cognitive impairments APP/PS1 mice by reducing plaque inflammation, signifying potential value clinical application for treatment.
Язык: Английский
Процитировано
0
Journal of Nanotheranostics, Год журнала: 2025, Номер 6(1), С. 8 - 8
Опубликована: Март 7, 2025
Photodynamic and photothermal therapies with IR780 have gained exponential interest, their photophysical properties demonstrated promise for use in antitumor antimicrobial chemotherapy. its derivatives are valuable labeling nanostructures different chemical compositions vitro vivo fluorescence monitoring studies the near-infrared (NIR) spectrum. The current literature is abundant on this topic, particularly applications treatment of types cancer using laser illumination to produce photodynamic (PDT), (PTT), and, more recently, sonodynamic therapy (SDT) approaches cell death. This review aims update state art concerning photosensitizer as a theranostic agent PDT, PTT, SDT, photoacoustic (PA) effects, imaging associated nanocarriers. concerns period from 2017 2024, considering, specifically, effects found preclinical experiments. Some aspects stability nanostructured systems will be discussed based evidence leakage nanocarrier consequences reliable analysis biological data.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161784 - 161784
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
JACS Au, Год журнала: 2025, Номер unknown
Опубликована: Март 31, 2025
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, number AD cases projected to exceed 131 million, placing significant strain on healthcare systems economies worldwide. The pathogenesis multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, inflammation. Despite extensive research, complexity these potentially entangled mechanisms has hindered development treatments that can reverse progression. Nanotechnology, leveraging unique physical, electrical, magnetic, optical properties nanomaterials, emerged promising approach for treatment. In this Perspective, we first outlined major current pathogenic hypotheses then reviewed recent advances in nanomaterials addressing hypotheses. We have also discussed challenges translating into clinical applications proposed future directions, particularly multifunctional multitarget enhance their therapeutic efficacy applicability
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101841 - 101841
Опубликована: Май 8, 2025
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 16, 2025
Abstract The rapidly advancing field of theranostics aims to integrate therapeutic and diagnostic functionalities into a single platform for precision medicine, enabling the simultaneous treatment monitoring diseases. Photo‐energy conversion‐based nanomaterials have emerged as versatile that utilizes unique properties light activate with high spatial temporal precision. This review provides comprehensive overview recent developments in photo‐energy conversion using nanomaterials, highlighting their applications disease theranostics. discussion begins by exploring fundamental principles including types materials used various light‐triggered mechanisms, such photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered SERS, photodynamic processes. Following this, delves broad spectrum emphasizing role diagnosis major diseases, cancer, neurodegenerative disorders, retinal degeneration, osteoarthritis. Finally, challenges opportunities technologies are discussed, aiming advance personalized medicine.
Язык: Английский
Процитировано
0