Modified probiotics and the related combinatorial therapeutics

Acta Pharmaceutica Sinica B, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Beta-Sitosterol-Conjugated Sinapic Acid-Engineered Nanoliposome: Biomucoadhesive and Enzyme-Responsive Targeted Oral Therapy in Ulcerative Colitis

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Developing oral drug delivery systems is promising for ulcerative colitis (UC). However, the key challenges, including formulation degradation under harsh gastric conditions, poor targeting efficiency, and limited colonic residence, lead to therapeutic efficacy that still needs be tackled. Effective treatment requires a safe, efficacious, enzyme- pH-responsive, biomucoadhesive system overcome these challenges. Therefore, we have developed chitosan-armored 1,2-dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) nanoliposomes amalgamated with synthesized beta-sitosterol-sinapic acid (Be-S) conjugate, further encapsulated 3,4-methylenedioxy-β-nitrostyrene (MNS) as NLRP3 inhibitor, termed C@MN@DMBe-S, limitation of free MNS sinapic acid. Formulated by thin-film hydration method processed through extrusion, unilamellar liposomes demonstrated structural stability mucoadhesive properties due chitosan coating. This configuration protected from acidic environment allowed retention in inflamed colon 48 h. The enzyme-responsive C@MN@DMBe-S nanoliposome releases at site via esterase activity, providing sustained controlled release MNS. synergistic action delivers antioxidant anti-inflammatory effects while influencing gut microbiota composition releasing short-chain fatty acids. Moreover, investigations revealed exhibited superior compared when administered orally. effectively downregulated NF-κB, NLRP3, Caspase-1, IL-1β expression upregulating MUC5AC expression, indicating enhanced protective thereby promoting mucosal healing. In addition, was found regulate immune cell downregulate neutrophil infiltration. armor- strategy elucidates impact nanomedicines on mitigating UC an effective treatment.

Язык: Английский

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The characteristics of sodium alginate-tremella polysaccharide assembled hydrogel induced by calcium ion and its protective effect on Lactobacillus rhamnosus

Food Hydrocolloids, Год журнала: 2024, Номер 160, С. 110732 - 110732

Опубликована: Окт. 11, 2024

Язык: Английский

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Self-assembled and intestine-targeting florfenicol nano-micelles effectively inhibit drug-resistant Salmonella typhimurium, eradicate biofilm, and maintain intestinal homeostasis

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101226 - 101226

Опубликована: Фев. 1, 2025

Язык: Английский

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Multienzyme Active Melanin Nanodots for Antioxidant-Immunomodulatory Therapy of Hyperoxia Lung Injury

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101609 - 101609

Опубликована: Фев. 25, 2025

Язык: Английский

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Marine Polysaccharides Hydrogel with Encapsulated Mesalazine for the Treatment of Ulcerative Colitis: Integrative Effects on Inflammation, Microbiota, and Mucosal Repair

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 253, С. 114722 - 114722

Опубликована: Апрель 18, 2025

Язык: Английский

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Carboxymethyl chitosan-dialdehyde glucan/polydopamine carrier targeted delivery Bacillus subtilis on enhancing oral utilization and intestinal colonization in mice

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 280, С. 135574 - 135574

Опубликована: Сен. 11, 2024

Язык: Английский

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