Ultrasound-activated mechanochemical reactions for controllable biomedical applications
Maocheng Zuo,
Rong Xiao,
Fangxue Du
и другие.
Smart Materials in Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Integrating oxygen-boosted sonodynamic therapy and ferroptosis via engineered exosomes for effective cancer treatment
Theranostics,
Год журнала:
2024,
Номер
15(1), С. 68 - 85
Опубликована: Дек. 2, 2024
Rationale:
Ferroptosis
and
sonodynamic
therapy
(SDT)
are
both
promising
therapeutic
modalities,
but
their
clinical
application
remains
challenging
due
to
the
hypoxic
tumor
microenvironment
limited
supply
of
polyunsaturated
fatty
acids.
Developing
an
agent
with
oxygen-enhanced
SDT
increased
ferroptosis
sensitivity
is
crucial
for
advancing
therapy.
Methods:
In
this
study,
catalase
(Cat)
Acyl-CoA
synthetase
long-chain
family
member
4
(ACSL4)
highly
expressed
4T1
cells
were
constructed
via
lentivirus
transfection.
Cat
ACSL4
enriched
exosomes
(EXO@CA)
then
extracted
loaded
sonosensitizer
tetrakis
(4-carboxyphenyl)
porphyrin
(TCPP)
through
electroporation
create
engineered
(EXO@CAT).
We
evaluated
ability
EXO@CAT
generate
oxygen
in
a
hydrogen
peroxide
environment
investigated
its
effect
on
motion
profiles
permeability
EXO@CAT.
The
vitro
antitumor
activity
was
assessed
cytotoxicity,
ROS
levels,
live/dead
staining,
apoptosis,
biomarkers
confirming
activation.
also
vivo
anticancer
efficacy
by
growth
analysis
histological
immunohistochemical
staining
mouse
models
bearing
breast
tumor.
Results:
harnesses
ultrasound
stimulation
facilitate
oxygen-enriched
SDT,
demonstrating
significant
capacity
singlet
(1O2)
generating,
which
promotes
accumulation
lipid
peroxidation
(LPO),
ultimately
leading
induction
ferroptosis.
Concurrently,
released
from
increases
LPO
modifying
cellular
composition,
thereby
enhancing
Moreover,
experiments
demonstrate
that
homologous
targeting
enables
efficient
tissues,
generation
catalyzed
not
only
alleviates
hypoxia
facilitates
penetration
into
deeper
layers
tissue.
Conclusions:
combines
endogenous
proteins,
prone
inactivation,
exogenous
sonosensitizer,
allowing
synergistic
treatment
improved
efficacy.
Язык: Английский
Nanozyme-based therapeutic strategies for rheumatoid arthritis
Journal of Controlled Release,
Год журнала:
2024,
Номер
377, С. 716 - 734
Опубликована: Дек. 3, 2024
Язык: Английский
Macrophage and mitochondria targeted nanoplatform to deplete and polarize M1-like macrophages for rheumatoid arthritis treatment
Chemical Engineering Journal,
Год журнала:
2024,
Номер
503, С. 158468 - 158468
Опубликована: Дек. 10, 2024
Язык: Английский
Targeting Reactive Oxygen Species for Diagnosis of Various Diseases
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(12), С. 378 - 378
Опубликована: Дек. 15, 2024
Reactive
oxygen
species
(ROS)
are
generated
predominantly
during
cellular
respiration
and
play
a
significant
role
in
signaling
within
the
cell
between
cells.
However,
excessive
accumulation
of
ROS
can
lead
to
dysfunction,
disease
progression,
apoptosis
that
organ
dysfunction.
To
overcome
short
half-life
relatively
small
amount
produced,
various
imaging
methods
have
been
developed,
using
both
endogenous
exogenous
means
monitor
settings.
In
this
review,
we
discuss
molecular
mechanisms
underlying
production
explore
materials
could
be
used
detect
overproduction,
including
iron-based
materials,
ROS-responsive
chemical
bond
containing
polymers,
molecule
biomaterials.
We
also
techniques
target
overproduction.
potentials
established
clinical
methods,
such
as
magnetic
resonance
(MRI),
sonographic
imaging,
fluorescence
imaging.
other
photoacoustic
(PAI)
Raman
(RI)
currently
preclinical
stage
discussed.
Finally,
paper
focuses
on
diseases
associated
with
current
future
applications
ROS-targeted
While
most
widely
condition
is
cardiovascular
diseases,
its
potential
extends
into
non-cardiovascular
conditions,
neurovascular,
neurodegenerative,
ROS-associated
cancers,
skin
aging,
acute
kidney
injury,
inflammatory
arthritis.
Язык: Английский