Targeting Reactive Oxygen Species for Diagnosis of Various Diseases DOI Creative Commons

Moung Young Lee,

Dong‐Uk Lee, Dong‐Kug Choi

и другие.

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(12), С. 378 - 378

Опубликована: Дек. 15, 2024

Reactive oxygen species (ROS) are generated predominantly during cellular respiration and play a significant role in signaling within the cell between cells. However, excessive accumulation of ROS can lead to dysfunction, disease progression, apoptosis that organ dysfunction. To overcome short half-life relatively small amount produced, various imaging methods have been developed, using both endogenous exogenous means monitor settings. In this review, we discuss molecular mechanisms underlying production explore materials could be used detect overproduction, including iron-based materials, ROS-responsive chemical bond containing polymers, molecule biomaterials. We also techniques target overproduction. potentials established clinical methods, such as magnetic resonance (MRI), sonographic imaging, fluorescence imaging. other photoacoustic (PAI) Raman (RI) currently preclinical stage discussed. Finally, paper focuses on diseases associated with current future applications ROS-targeted While most widely condition is cardiovascular diseases, its potential extends into non-cardiovascular conditions, neurovascular, neurodegenerative, ROS-associated cancers, skin aging, acute kidney injury, inflammatory arthritis.

Язык: Английский

Ultrasound-activated mechanochemical reactions for controllable biomedical applications DOI Creative Commons

Maocheng Zuo,

Rong Xiao,

Fangxue Du

и другие.

Smart Materials in Medicine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

7

Integrating oxygen-boosted sonodynamic therapy and ferroptosis via engineered exosomes for effective cancer treatment DOI Creative Commons
Mingbo Wu,

Zhanlin Zhang,

Dong Li

и другие.

Theranostics, Год журнала: 2024, Номер 15(1), С. 68 - 85

Опубликована: Дек. 2, 2024

Rationale: Ferroptosis and sonodynamic therapy (SDT) are both promising therapeutic modalities, but their clinical application remains challenging due to the hypoxic tumor microenvironment limited supply of polyunsaturated fatty acids. Developing an agent with oxygen-enhanced SDT increased ferroptosis sensitivity is crucial for advancing therapy. Methods: In this study, catalase (Cat) Acyl-CoA synthetase long-chain family member 4 (ACSL4) highly expressed 4T1 cells were constructed via lentivirus transfection. Cat ACSL4 enriched exosomes (EXO@CA) then extracted loaded sonosensitizer tetrakis (4-carboxyphenyl) porphyrin (TCPP) through electroporation create engineered (EXO@CAT). We evaluated ability EXO@CAT generate oxygen in a hydrogen peroxide environment investigated its effect on motion profiles permeability EXO@CAT. The vitro antitumor activity was assessed cytotoxicity, ROS levels, live/dead staining, apoptosis, biomarkers confirming activation. also vivo anticancer efficacy by growth analysis histological immunohistochemical staining mouse models bearing breast tumor. Results: harnesses ultrasound stimulation facilitate oxygen-enriched SDT, demonstrating significant capacity singlet (1O2) generating, which promotes accumulation lipid peroxidation (LPO), ultimately leading induction ferroptosis. Concurrently, released from increases LPO modifying cellular composition, thereby enhancing Moreover, experiments demonstrate that homologous targeting enables efficient tissues, generation catalyzed not only alleviates hypoxia facilitates penetration into deeper layers tissue. Conclusions: combines endogenous proteins, prone inactivation, exogenous sonosensitizer, allowing synergistic treatment improved efficacy.

Язык: Английский

Процитировано

4

Nanozyme-based therapeutic strategies for rheumatoid arthritis DOI

Jucong Zhang,

Chenxi Wang,

Xiaochuan Wu

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 716 - 734

Опубликована: Дек. 3, 2024

Язык: Английский

Процитировано

3

Macrophage and mitochondria targeted nanoplatform to deplete and polarize M1-like macrophages for rheumatoid arthritis treatment DOI

Ning Guo,

Wenhong Zhou, Ziying Zhang

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 503, С. 158468 - 158468

Опубликована: Дек. 10, 2024

Язык: Английский

Процитировано

1

Targeting Reactive Oxygen Species for Diagnosis of Various Diseases DOI Creative Commons

Moung Young Lee,

Dong‐Uk Lee, Dong‐Kug Choi

и другие.

Journal of Functional Biomaterials, Год журнала: 2024, Номер 15(12), С. 378 - 378

Опубликована: Дек. 15, 2024

Reactive oxygen species (ROS) are generated predominantly during cellular respiration and play a significant role in signaling within the cell between cells. However, excessive accumulation of ROS can lead to dysfunction, disease progression, apoptosis that organ dysfunction. To overcome short half-life relatively small amount produced, various imaging methods have been developed, using both endogenous exogenous means monitor settings. In this review, we discuss molecular mechanisms underlying production explore materials could be used detect overproduction, including iron-based materials, ROS-responsive chemical bond containing polymers, molecule biomaterials. We also techniques target overproduction. potentials established clinical methods, such as magnetic resonance (MRI), sonographic imaging, fluorescence imaging. other photoacoustic (PAI) Raman (RI) currently preclinical stage discussed. Finally, paper focuses on diseases associated with current future applications ROS-targeted While most widely condition is cardiovascular diseases, its potential extends into non-cardiovascular conditions, neurovascular, neurodegenerative, ROS-associated cancers, skin aging, acute kidney injury, inflammatory arthritis.

Язык: Английский

Процитировано

1