Study on Highly Sensitive Capacitive Pressure Sensor Based on Silk Fibroin-Lignin Nanoparticles Hydrogel
Biomacromolecules,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Silk
fibroin
(SF)
hydrogel
has
been
proven
to
have
excellent
applications
in
the
field
of
pressure
sensors,
but
its
sensing
performance
still
needs
improvement.
A
flexible
prepared
from
natural
macromolecular
materials
was
developed,
and
lignin
nanoparticles
(LNPs)
were
introduced
during
preparation
SF
hydrogel.
When
LNPs
account
for
3%
SF,
unit
SF-LNPs3%
exhibits
high
stress
sensitivity
(1.32
kPa–1),
fast
response
speed
(<0.1
s),
superior
cycle
stability
(≥8000
cycles).
The
sensor
can
detect
human
motion
information,
such
as
finger
bending,
elbow
pulse
signals.
worn
at
vocal
cord
position,
it
peak
value
characteristic
signal
wearer
speaks.
This
work
demonstrates
that
shows
great
potential
sensors.
Язык: Английский
Qingre Huayu Jianpi prescription alleviates the inflammatory transformation of colitis-associated colorectal cancer by inhibiting the IL-17RA/ACT1/NF-κB axis
Yilin Duan,
Yao Lü,
Zhenglin Liu
и другие.
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
345, С. 119554 - 119554
Опубликована: Март 3, 2025
Язык: Английский
Epidermal Mechanical Scratching-Induced ROS Exacerbates the Itch-Scratch Cycle via TRPA1 Activation on Mast Cells in Atopic Dermatitis
Journal of Investigative Dermatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Immunomodulatory All-Natural Kelp Decellularized Scaffold Prepared Using Deep Eutectic Solvent with Angiogenic Properties for Accelerating Diabetic Wound Healing
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Excessive
oxidative
stress,
chronic
inflammation,
and
impaired
vascularization
are
the
main
barriers
to
diabetic
wound
repair.
A
decellularized
extracellular
matrix
(dECM)
with
a
native
ECM
structure
is
promising
biomaterial
candidate
for
healing.
However,
traditional
decellularization
process
(reagents)
can
diminish
structural
stability,
mechanical
properties,
bioactive
components
of
dECM.
To
address
these
issues,
we
developed
an
intrinsically
kelp
scaffold
(Im-Gly2)
using
natural
gentle
deep
eutectic
solvents
(DES)
accelerating
Im-Gly2
had
stable
porous
3D
(80.7
μm)
suitable
which
could
support
cell
growth,
proliferation,
migration.
Due
retention
fucoidan,
polyphenols
(735.3
μg/g),
flavonoids,
demonstrated
intrinsic
antioxidant
immunomodulatory
effects.
It
effectively
reduced
reactive
oxygen
species
(ROS)
production
in
RAW264.7
macrophages
promoted
their
differentiation
into
M2
phenotype.
Notably,
tube
formation
through
paracrine
mechanisms
by
inducing
expression
transforming
proliferative
cytokines
from
macrophage.
In
vivo,
accelerated
healing
wounds
alleviating
angiogenesis,
granulation
tissue
formation,
collagen
deposition,
re-epithelialization.
Taken
together,
our
study
provides
novel
strategy
fabricating
dECM
without
cross-linking
exogenous
substances
Язык: Английский
Targeted Self-Assembled anti-NFκB AuNCs-Aptamer Nanoplatform for Precise Theranostics via Tailored Follicle Regeneration
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101774 - 101774
Опубликована: Апрель 17, 2025
NFκB
is
a
vital
transcription
factor
for
the
regulation
of
hair
follicle
cycle.
As
therapeutic
target,
specifically
blocked
by
RNA
aptamer
with
negligible
side
effects,
but
targeted
transmembrane
transport
anti-NFκB
remains
challenge
due
to
its
negative
charge
under
physiological
conditions.
In
this
study,
taking
advantage
depilation-induced
oxidative
stress
microenvironment
(OSM),
it
was
confirmed
first
time
that
self-assembled
gold
nanoclusters
and
(AuNCs-Aptamer)
complexes
formed
in
skin
enhanced
effect
drugs,
effectively
blocking
NFκB-mediated
inflammatory
response
inhibiting
regeneration.
The
hematoxylin-eosin
(HE)
staining
tissue
section
hematology
analysis
demonstrated
OSM-responsive
AuNCs-Aptamer
caused
no
toxicity
living
organism.
Moreover,
self-assembly
occurred
only
stress-injured
cells
rather
than
normal
cells,
which
revealed
targeted,
safe
effective
therapy
hypertrichosis.
Язык: Английский
Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
disorder
marked
by
thickening,
severe
pruritus,
lesions,
and
emotional
disturbances,
including
anxiety
depression-like
behavior.
Current
treatments
primarily
rely
on
localized
therapies,
which
can
lead
to
adverse
effects
such
as
hyperglycemia
Cushing's
syndrome
with
repeated
use.
To
address
these
issues,
we
developed
hyaluronic
acid-based
separable
microneedle
patch
(Dic@pCu-HA
MN),
integrating
polydopamine-coordinated
copper-based
metal-organic
frameworks
(pCu-MOFs)
the
anti-inflammatory
agent
dictamnine
(Dic),
for
synergistic
management
of
AD
its
neuropsychiatric
comorbidities.
pCu-MOFs
exhibited
dual
functionality
nanocargo
hydrophobic
Dic
(encapsulation
efficiency:
84.62
±
2.14%)
multienzyme
mimics
that
efficiently
scavenge
reactive
oxygen
species
(ROS)
(superoxide
radical
scavenging:
63.85
0.34%).
In
vitro
release
studies
demonstrated
ROS-responsive
86.80
4.83%
over
48
h
under
pathology-mimicking
conditions.
1-Chloro-2,4-dinitrochlorobenzene
(DNCB)-induced
mouse
model,
Dic@pCu-HA
MN
significantly
reduced
oxidative
stress
(8-OHdG:
85.1
7.0%
decrease),
suppressed
pro-inflammatory
cytokines
(IL-4:
70.0
7.8%
decrease
vs
control),
restored
barrier
integrity.
By
modulating
HPA
axis,
system
attenuated
neuroinflammation
alleviated
itching
(scratching
frequency:
40.1
41.3%
reduction)
behavior
(time
in
bright
box:
96.6
156.2%
increase).
This
combined
therapeutic
approach
not
only
offers
comprehensive
strategy
but
also
provides
potential
benefits
addressing
disorders
their
sequelae.
Язык: Английский
Oxidative stress products and managements in atopic dermatitis
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Май 9, 2025
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
disorder
that
affects
significant
portion
of
the
global
population,
severely
impacting
quality
life
and
causing
physical
psychological
distress
patients.
Oxidative
stress,
resulting
from
an
imbalance
between
oxidation
antioxidation
activities,
plays
pivotal
role
in
pathogenesis
AD.
Monitoring
oxidative
stress
products
can
offer
valuable
insights
into
development
AD
highlight
essential
clinical
therapeutic
effects.
Additionally,
evidence
suggests
antioxidant
strategies
alleviate
or
avert
damage
induced
by
free
radicals
promise
treatment
In
addition
to
directly
utilizing
natural
nanomaterials
for
interventions,
these
also
be
incorporated
hydrogels,
which
help
repair
barrier
support
sustained
release
agents.
Furthermore,
microneedles
provide
minimally
invasive
method
delivering
antioxidants
deeper
layers
skin,
enhancing
efficacy.
This
review
aims
summarize
AD,
focusing
main
(DNA,
protein,
lipid
products),
as
well
approaches
involving
products,
nanomaterials,
microneedles.
Understanding
biomarkers
therapy
provides
important
management
Язык: Английский
A review on tailoring lignin derivatives for sunscreen formulations: Structural modification and antioxidant properties for enhanced UV protection
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 144871 - 144871
Опубликована: Июнь 1, 2025
Язык: Английский
Chemical Synthesis of Monolignols: Traditional Methods, Recent Advances, and Future Challenges in Sustainable Processes
Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1387 - 1387
Опубликована: Ноя. 14, 2024
Monolignols
represent
pivotal
alcohol-based
constituents
in
lignin
synthesis,
playing
indispensable
roles
plant
growth
and
development
with
profound
implications
for
industries
reliant
on
wood
paper.
their
derivates
have
multiple
applications
several
industries.
exhibit
antioxidant
activity
due
to
ability
donate
hydrogen
atoms
or
electrons
neutralize
free
radicals,
thus
preventing
oxidative
stress
damage
cells.
Characterized
by
alcohol
functionalities,
monolignols
present
three
main
forms:
p-coumaryl
alcohol,
coniferyl
sinapyl
alcohol.
In
nature,
particularly
plants,
geometry
(E)
predominate
over
Z
counterparts.
The
methods
obtaining
the
canonical
monolignols,
two
less-common
a
monolignol
analogue
are
addressed
an
overview
of
these
phenol-based
compounds,
from
synthetic
standpoint.
A
SWOT
(Strengths,
Weaknesses,
Opportunities,
Threats)
analysis
is
used
explain
advantages
disadvantages
synthesizing
key
alcohol-containing
raw
materials
enormous
significance
both
biology
industrial
applications,
using
bench
chemical
methods.
uniqueness
this
work
that
it
provides
pathways
assist
researchers
pharmaceutical
biological
fields
selecting
appropriate
procedure
preparation
models.
Moreover,
we
aim
inspire
scientists,
chemists,
develop
more
sustainable
protocols
monolignols.
Язык: Английский
Sodium Propionate Alleviates Atopic Dermatitis by Inhibiting Ferroptosis via Activation of LTBP2/FABP4 Signaling Pathway
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 10047 - 10064
Опубликована: Ноя. 1, 2024
Atopic
dermatitis
(AD)
is
a
common
pediatric
skin
disease,
with
recent
studies
suggesting
role
for
ferroptosis
in
its
pathogenesis.
Sodium
propionate
(SP)
has
shown
therapeutic
potential
AD,
yet
mechanism,
particularly
regarding
modulation,
remains
unclear.
This
study
aims
to
explore
whether
SP
alleviates
AD
by
modulating
ferroptosis-related
pathways
through
bioinformatic
and
vitro
analyses.
Язык: Английский