Materials Today Bio, Год журнала: 2025, Номер 31, С. 101583 - 101583

Опубликована: Фев. 16, 2025

The application of Nanocarriers (NCs) provides a promising strategy to solve the problems faced by traditional chemotherapy drugs, like imprecise delivery, poor bioavailability, high dose requirement, and tendency develop multidrug resistance. With protection NCs, drugs can reach lesion site then release accurately completely. Although some reviews have summarized biological applications little attention has been given advantages disadvantages analyzing organic, inorganic, hybrid NCs separately for targeted therapy identifying means further improve targeting ability. First, in this review, we emphasize three factors that marked impact on therapy: tumor microenvironment (TME), different administration modalities (intravenous, oral, intracavitary administration), pathways (passive active). Second, systematic examination polymeric dendrimers, micelles, liposomes, mesoporous silica gold quantum dots, nano clay, core-shell MOFs are reviewed. Further, propose ways efficiency therapy, including regulating size, shape, surface properties NCs.

Язык: Английский