Dual peptide-coordinated dynamic hydrogel with antibacterial and proangiogenic activities for infected skin wounds DOI
Li Ni, Xiaoyu Zhang,

Jia Gao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138349 - 138349

Опубликована: Дек. 4, 2024

Язык: Английский

MMP-9 responsive hydrogel promotes diabetic wound healing by suppressing ferroptosis of endothelial cells DOI
Chuanlu Lin, Yiqiang Hu,

Ze Lin

и другие.

Bioactive Materials, Год журнала: 2024, Номер 43, С. 240 - 254

Опубликована: Сен. 25, 2024

Язык: Английский

Процитировано

7
Advancing wound healing by hydrogel-based dressings loaded with cell-conditioned medium: a systematic review DOI Creative Commons

Galina Nifontova,

Sofia Safaryan,

Yana Khristidis

и другие.

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 17, 2024

Wound healing represents a complex biological process, critically important in clinical practice due to its direct implication patient's recovery and quality of life. Conservative wound management frequently falls short providing an ideal environment for the optimal tissue regeneration, often resulting extended periods elevated risk infection other complications. The emerging biomaterials, particularly hydrogels, have shown substantial promise addressing these challenges by offering properties such as biocompatibility, biodegradability, ability cure environment. Recent advancements highlighted therapeutic potential integrating cell-derived conditioned medium (CM) into hydrogel matrices. Cell-derived CM rich array bioactive molecules, demonstrating significant efficacy modulating cellular activities crucial healing, including proliferation, migration, angiogenesis.

Язык: Английский

Процитировано

7
Microenvironment-Responsive Antibacterial, Anti-Inflammatory, and Antioxidant Pickering Emulsion Stabilized by Curcumin-Loaded Tea Polyphenol Particles for Accelerating Infected Wound Healing DOI

Qiulan Tong,

Yi Zeng, Лей Ма

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(34), С. 44467 - 44484

Опубликована: Авг. 14, 2024

Multiphase Pickering emulsions, including two or more active agents, are of great importance to effectively manage complicated wounds. However, current strategies based on emulsions still unsatisfying since they involve only stabilization by inactive particles and encapsulation the hydrophobic drugs in oil phase. Herein, thyme essential (TEO) was encapsulated shell functional tea polyphenol (TP)-curcumin (Cur) nanoparticles (TC NPs) exemplarily develop a novel emulsion (TEO/TC PE). Hydrophobic Cur loaded with hydrophilic TP obtain TC NPs, under homogenization, these NPs adsorbed surface TEO droplets form stable core-shell structure. Owing such an oil-in-water (O/W) structure, sequential release first from pH-responsive disintegrated then leaked yielded synergetic functions TEO/TC PE, leading enhanced antibacterial, biofilm elimination, antioxidant, anti-inflammatory activities. This injectable PE applied treat infected full-thickness skin defects, satisfactory wound healing effects were achieved rapid angiogenesis, collagen deposition, regeneration. The present constituted entirely plant-sourced products is biosafe expected spearhead future development dressings.

Язык: Английский

Процитировано

5
Foam-based antibacterial hydrogel composed of carboxymethyl cellulose/polyvinyl alcohol/cerium oxide nanoparticles for potential wound dressing DOI
Burcu Orhan, Duygu Karadeniz, Zeynep Kalaycıoğlu

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138924 - 138924

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

4
Collagen-based micro/nanogel delivery systems: Manufacturing, release mechanisms, and biomedical applications DOI Creative Commons

Bowei Du,

Shanhui Feng, J. Wang

и другие.

Chinese Medical Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Abstract Collagen-based materials, renowned for their biocompatibility and minimal immunogenicity, serve as exemplary substrates in a myriad of biomedical applications. micro/nanogels, particular, are valued increased surface area, tunable degradation rates, ability to facilitate targeted drug delivery, making them instrumental advanced therapeutics tissue engineering endeavors. Although extensive reviews on micro/nanogels exist, they tend cover wide range biomaterials lack specific focus collagen-based materials. The current review offers an in-depth look into the manufacturing technologies, release mechanisms, applications address this gap. First, we provide overview synthetic strategies that allow precise control size, shape, mechanical strength these by controlling degree cross-linking These properties crucial performance We then highlight environmental responsiveness particularly sensitivity enzymes pH, which enables controlled under various pathological conditions. discussion expands include cancer therapy, antimicrobial treatments, bone repair, imaging diagnosis, emphasizing versatility potential critical areas. challenges future perspectives field discussed at end review, with emphasis translation clinical practice. This comprehensive serves valuable resource researchers, clinicians, scientists alike, providing insights state directions micro/nanogel research development.

Язык: Английский

Процитировано

0
Adhesive and antibacterial guar gum-based nanocomposite hydrogel for remodeling wound healing microenvironment DOI
Weiwei Zhang, Qin He,

Ziming Jin

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139054 - 139054

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1
Dual peptide-coordinated dynamic hydrogel with antibacterial and proangiogenic activities for infected skin wounds DOI
Li Ni, Xiaoyu Zhang,

Jia Gao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 285, С. 138349 - 138349

Опубликована: Дек. 4, 2024

Язык: Английский

Процитировано

0