bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 7, 2024
Abstract
This
study
focuses
on
addressing
the
challenges
of
dental
implants
in
geriatric
population
by
enhancing
bioactivity
polyetheretherketone
(PEEK)
through
surface
modification.
PEEK,
with
its
elastic
modulus
close
to
alveolar
bone,
mitigates
stress
shielding
but
faces
limitations
osseointegration
due
low
bioactivity.
We
introduced
zinc
(Zn)
and
metformin
(MF)
onto
PEEK
surfaces
via
a
dopamine-assisted
physical
adhesion
method,
creating
functionalized
derivative
called
ZnMF@PEEK.
combination
targets
diminished
osteogenic
potential,
persistent
inflammation,
cell
senescence,
which
are
common
issues
elderly
patients.
Comprehensive
physicochemical
characterizations
confirmed
successful
preparation
ZnMF@PEEK,
vitro
vivo
experiments
systematically
evaluated
biocompatibility
The
results
indicate
that
ZnMF@PEEK
holds
promise
as
implant
material
tailored
specific
needs
elderly,
multifaceted
osseointegration.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Medical
catheters
are
susceptible
to
biological
contamination
and
pathogen
invasion,
leading
infection
inflammatory
complications.
The
development
of
antimicrobial
coatings
for
medical
devices
has
emerged
as
a
promising
strategy.
However,
limited
functionality
the
incompatibility
between
bactericidal
properties
biosafety
remain
great
challenges.
Herein,
multifunctional
polymer
coating
(CPB-Ac)
is
created,
incorporating
an
ultrasonic-responsive
carbon
monoxide
release
unit
(CORM-Ac)
antifouling
treat
catheter-related
As-synthesized
CPB-Ac
can
be
stably
anchored
various
with
arbitrary
shapes
compositions
via
facile
UV
treatment.
Both
in
vivo
vitro
experiments
demonstrated
that
this
multi-functional
exhibits
anti-fouling,
anti-inflammatory,
broad-spectrum
antibacterial
activities
well
good
biosafety.
During
initial
implantation
phase,
units
effectively
inhibit
attachment
contaminants,
significantly
reducing
risk
thrombosis
bacterial
infection.
Once
occurs,
ultrasonic
irradiation
activate
CO
much
higher
amount
55.3
µm
than
non-ultrasound
controls,
therefore
rapidly
eliminating
bacteria
alleviating
response.
It
believed
work
may
provide
effective
method
next-generation
intelligent
against
This
study
evaluates
the
clinical
outcomes
associated
with
use
of
an
improved
polyetheretherketone
(PEEK)
cranial
plate
in
cranioplasty
surgery.
A
total
104
patients
were
involved,
significant
findings
revealing
a
reduced
incidence
postoperative
adverse
reactions
PEEK
group
(28.85%)
compared
to
conventional
(50.00%,
P
=
0.027).
Patient
satisfaction
rates
markedly
higher
cohort
(P
<
0.05).
Although
medical
expenses
for
enhanced
greater
(¥
144
600
±
21
200
vs
¥
127
400
20
100,
0.05),
there
no
notable
differences
cerebral
blood
flow
perfusion
or
survival
time
between
two
groups
>
The
conclusions
indicate
that
while
plates
incur
upfront
costs,
their
benefits
terms
safety
and
patient
satisfaction,
along
implant
stability
bone
healing,
support
practice.
Consequently,
upgraded
material
is
recommended
procedures.
