Synergistic Functions of the Janus Fibrous Membrane for Enhanced Bone Repair

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

The treatment of bone defects presents significant challenges in clinical practice. Guided regeneration (GBR) strategies offer a new approach, but existing commercial GBR membranes still lack optimal barrier and osteogenic functions. This study the design Janus fibrous membrane using classic amphiphilic block copolymers gelatin methacryloyl containing unsaturated double bonds through gradient electrospinning process. Specifically, by controlling parameters, self-assembly copolymers, secondary photo-cross-linking, differential composition, topological structure, properties between different layers were achieved, thereby realizing synergistic physiological repair-promoting By leveraging effect, it effectively blocks adverse effects soft tissue cell ingrowth on repair while guiding proliferation differentiation. Furthermore, membrane's functionality is optimized incorporating antimicrobial component ε-poly-l-lysine niobium. In vivo studies demonstrate excellent biocompatibility, antibacterial activity, remarkable potential both normal infectious defect animal models. developed serves as versatile platform for biomedical applications, offering vast to address limitations current treatment.

Язык: Английский

Constructing Self‐Renewing Silicone‐Hydrogel Hybrid Coatings with Integrated Fouling Resistant/Release/Killing Mode toward Superior Biofouling Defense

Small, Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Abstract Silicone hydrogel coatings, which integrate fouling self‐release and resistant properties, represent a groundbreaking advancement in environmentally friendly biofouling mitigation, but are still plagued by static conditions longevity concerns. In this work, Schiff base chemistry sol‐gel technique is leverage to develop degradable silicone‐hydrogel hybrid antifouling coatings incorporating amphiphilic silicone‐based polymers with terephthalaldehyde (TPE) cinnamaldehyde (CAL). The synergistic combination of flexible Si─O bonds the polymer backbone reversible covalent crosslinking imparts exceptional flexibility (hardness 0.135), controlled degradability, dynamic surface self‐renewal capabilities, ensuring sustained performance through stability. During degradation, will self‐enrich at interface, forming dual‐functional that combines release resists properties. antibacterial TPE natural CAL, anchored within network, exhibit environment‐responsive behavior, effectively suppressing bacterial proliferation biofilm adhesion. optimized coating achieves bactericidal rate 98.8%, an anti‐bacterial adhesion 99.8%, predicted anti‐fouling 5.5 years thickness 200 µm. This innovative approach enables new anti‐biofouling involves unique control mode, thereby meeting diverse application.

Язык: Английский

Bioactive Peptide-Based Electroactive Hydrogels for Myocardial Infarction Treatment via Electrical and Microenvironmental Regulation

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Postmyocardial infarction (MI), oxidative stress and insufficient blood supply contribute to impaired cardiac repair, while the subsequent formation of fibrotic scar tissue, characterized by poor electrical conductivity, further exacerbates dysfunction. Here, we compounded angiogenesis-promoting peptide (KRX) with effective pro-angiogenic effects conductive material carboxylated carbon nanotubes (CNTs) through electrostatic interaction, thus preparing CNT/KRX. Subsequently, prepared electroactive hydrogel (Gel@CK) compounding CNT/KRX natural polysaccharide hydrogel. This design endows both conductivity function promoting angiogenesis. In vitro, showed scavenging reactive oxygen species (ROS), cell compatibility, promoted endothelial MI model, significantly angiogenesis mitigated stress. Furthermore, it effectively shortened Q wave, R wave S (QRS) interval enhanced tissue integration. The indices measured echocardiography tests immunohistochemical analyses indicate that has improved reduced infarct size. composite demonstrates remarkable therapeutic potential for cardiovascular diseases dual modulation myocardial microenvironment activity.

Язык: Английский