Current Insights into the Radiobiology of Boron Neutron Capture Therapy and the Potential for Further Improving Biological Effectiveness DOI Creative Commons

Leah D. Punshon,

Maria Rita Fabbrizi, Ben Phoenix

и другие.

Cells, Год журнала: 2024, Номер 13(24), С. 2065 - 2065

Опубликована: Дек. 13, 2024

Photon (X-ray) radiotherapy is the most common treatment used in cancer therapy. However, exposure of normal tissues and organs at risk to ionising radiation often results a significant incidence low-grade adverse side effects, whilst high-grade toxicities also occur concerningly high rates. As an alternative, boron neutron capture therapy (BNCT) aims create densely helium lithium ions directly within cells, thus sparing surrounding cells but leading significantly more effective tumour control than X-rays. Although very promising for patients with recurring highly invasive tumours, BNCT does not currently have widespread use worldwide, part due limited reliable sources clinical use. Another limitation devising strategies selective optimal accumulation cells. Boronophenylalanine (BPA) major compound which takes advantage amino acid transporter LAT1 that overexpressed number human cancers. Additionally, there lack in-depth knowledge regarding impact on cellular DNA, molecular mechanisms are responsive treatment, important developing therapeutic using BNCT, unclear. In this review, we highlight current radiobiology acquired from vitro vivo studies, particularly context DNA damage repair, present evidence established new boron-containing compounds aimed enhancing specificity effectiveness treatment.

Язык: Английский

Carborane in Polymers—Existent Stipulations and Technological Trademarks DOI
Ayesha Kausar

Polymer-Plastics Technology and Materials, Год журнала: 2025, Номер unknown, С. 1 - 27

Опубликована: Фев. 10, 2025

Язык: Английский

Процитировано

0
Current Insights into the Radiobiology of Boron Neutron Capture Therapy and the Potential for Further Improving Biological Effectiveness DOI Creative Commons

Leah D. Punshon,

Maria Rita Fabbrizi, Ben Phoenix

и другие.

Cells, Год журнала: 2024, Номер 13(24), С. 2065 - 2065

Опубликована: Дек. 13, 2024

Photon (X-ray) radiotherapy is the most common treatment used in cancer therapy. However, exposure of normal tissues and organs at risk to ionising radiation often results a significant incidence low-grade adverse side effects, whilst high-grade toxicities also occur concerningly high rates. As an alternative, boron neutron capture therapy (BNCT) aims create densely helium lithium ions directly within cells, thus sparing surrounding cells but leading significantly more effective tumour control than X-rays. Although very promising for patients with recurring highly invasive tumours, BNCT does not currently have widespread use worldwide, part due limited reliable sources clinical use. Another limitation devising strategies selective optimal accumulation cells. Boronophenylalanine (BPA) major compound which takes advantage amino acid transporter LAT1 that overexpressed number human cancers. Additionally, there lack in-depth knowledge regarding impact on cellular DNA, molecular mechanisms are responsive treatment, important developing therapeutic using BNCT, unclear. In this review, we highlight current radiobiology acquired from vitro vivo studies, particularly context DNA damage repair, present evidence established new boron-containing compounds aimed enhancing specificity effectiveness treatment.

Язык: Английский

Процитировано

0