Enzymatic Oxidants, Antioxidants, and Inflammatory Bowel Disease
Applied Biosciences,
Год журнала:
2025,
Номер
4(2), С. 19 - 19
Опубликована: Апрель 1, 2025
The
role
of
oxidants
and
antioxidants
in
inflammatory
bowel
disease
(IBD)
has
been
actively
explored
since
the
early
1980s,
starting
with
respiratory
burst
neutrophils
ischemia
pathology.
Since
that
time,
enzymatic
components
contributing
to
pool
reactive
oxygen
species,
including
superoxide,
H2O2,
lipid
hydroperoxides,
counteracting
antioxidants—catalase,
glutathione
peroxidases
(Gpx),
peroxiredoxins
(PRDX),
superoxide
dismutases,
others—have
fleshed
out.
My
perspective
on
IBD
is
from
balance
or
imbalance
oxidant
sources
process.
I
will
present
evidence
involvement
antioxidant
processes
based,
as
much
possible,
my
experiences
Gpxs.
This
be
discussed
terms
both
immune
system
local
systems.
As
Gpxs
are
generally
selenium-dependent,
possible
deficiencies
selenium
uptake
active
impact
Gpx
expression
explored.
more
recently
introduced
ferroptosis,
an
iron-dependent
peroxidation-based
pathological
process,
reviewed
for
its
IBD.
Язык: Английский
X-ray-Sensitive Selenium Nanoparticles Enhance Esophageal Squamous Cell Carcinoma Radiotherapy through Activating P53/IGFBP3 Pathway by Regulating GPX2
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
Radiotherapy
remains
a
crucial
treatment
for
esophageal
squamous
cell
carcinoma
(ESCC),
although
the
development
of
radiation
resistance
and
occurrence
radiation-induced
side
effects
pose
significant
clinical
challenges.
Selenium
(Se)
has
obvious
antitumor
effects,
but
sensitizing
effect
mechanism
Se
nanoparticles
in
ESCC
radiotherapy
remain
to
be
determined.
The
aim
this
study
was
investigate
which
form
have
superior
sensitization
how
(LNT-SeNPs)
can
enhance
radiosensitivity
ESCC.
Our
findings
indicate
that
LNT-SeNPs
exhibit
remarkable
radiosensitizing
activity
with
higher
safety
index.
These
effectively
inhibit
growth,
induce
S-phase
arrest,
promote
apoptosis
through
increased
reactive
oxygen
species
(ROS)
production.
Furthermore,
analysis
via
GEO
database
revealed
correlation
between
selenoprotein
GPX2
cancer.
Further
investigations
demonstrate
suppress
expression,
leading
cells
p53/IGFBP3
signaling
pathway.
In
conclusion,
elucidates
effectiveness
cancer,
providing
valuable
insights
into
potential
use
Se-based
drugs
as
adjunctive
therapy.
pave
way
future
applications
aimed
at
improving
therapeutic
outcomes
patients
undergoing
Язык: Английский
An Oral H2S Responsive Cu5.4O Nanozyme Platform with Strong ROS/H2S Scavenging Capacity for the Treatment of Colitis
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
17(1), С. 617 - 631
Опубликована: Дек. 25, 2024
Inflammatory
bowel
disease
involves
excess
reactive
oxygen
species
(ROS)
and
hydrogen
sulfide
(H2S)
at
inflammatory
sites.
Nanozyme-mediated
ROS
H2S
scavenging
therapy
is
promising
for
colitis
treatment.
Here,
we
synthesized
a
multiple
Cu5.4O
nanoparticle
first
explored
its
capacity.
Chitosan
oligosaccharide
modified
with
alpha-lipoic
acid
was
coated
on
the
nanoparticles
to
further
enhance
Furthermore,
calcium
alginate
surface
develop
an
oral
nanoplatform
(Cu5.4O@SAG)
possessing
dual-pH/H2S-responsive
release
characteristics.
Importantly,
Cu5.4O@SAG
exhibited
enrichment
colonic
inflammation
site
relieved
index,
containing
recovery
of
colon
length,
spleen
liver
body
weight,
as
well
cell
infiltration.
In
vivo
in
vitro
experiments
revealed
dual
capacities
nanoplatform.
Additionally,
regulated
tight
junctions,
mucus
layers,
gut
microbiota,
which
accompanied
by
downregulation
cytokines.
Notably,
also
had
excellent
biocompatibility.
conclusion,
this
multiple-scavenging
nanozyme
platform
provides
new
safe
paradigm
development
nanozymes
Язык: Английский
Nanozyme Hydrogels Promote Nerve Regeneration in Spinal Cord Injury by Reducing Oxidative Stress
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(44), С. 59949 - 59961
Опубликована: Окт. 25, 2024
Inhibiting
secondary
cell
death
and
promoting
neuronal
regeneration
are
critical
for
nerve
repair
after
spinal
cord
injury
(SCI).
The
excessive
accumulation
of
reactive
oxygen
species
(ROS)
SCI
causes
induces
apoptosis.
These
reactions
further
increase
the
level
ROS
production,
leading
to
a
vicious
cycle
tissue
damage.
Therefore,
intervention
targeting
is
potential
therapeutic
approach
improve
recovery
locomotor
function
SCI.
In
this
study,
we
designed
synthesized
nanozyme
hydrogel
delivery
system
loaded
with
multiple
drugs,
LA/Me/Se
NPs-h.
NPs-h
exhibited
satisfactory
size
distribution
excellent
stability,
enhancing
bioavailability
drugs.
Moreover,
explored
antioxidant
protective
effects
against
oxidative
stress-induced
damage
caused
by
production
in
vitro.
mice
model,
Basso
mouse
scale
gait
analysis
showed
that
significantly
promoted
histological
immunofluorescence
results
site
revealed
upregulated
expression
GFAP,
NF-200,
superoxide
dismutase
lesion,
reduced
caspase-3
expression,
improved
continuity,
lesion
cavity,
inhibited
axonal
demyelination.
Consequently,
increased
activity
enzymes
apoptosis
reducing
stress
ultimately
regeneration.
Taken
together,
study
demonstrated
promising
hydrogels
provided
an
effective
strategy
other
ROS-related
diseases.
Язык: Английский