Suture-Mediated Delivery System Reduces the Incidence of Uterine Scarring Through the TGF-β Pathway

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(2), С. 52 - 52

Опубликована: Фев. 7, 2025

In recent years, factors such as the postponement of childbearing and relaxation policy have led to an increase in proportion cesarean sections other intrauterine surgeries among pregnant women, further increasing incidence uterine scars. Currently, there is a lack effective clinical treatment methods for this study, suture loaded with gene medicine was designed repair Specifically, non-viral vector Lipo8000 first used form complex solution plasmid TGF-β3. Then, it mixed adsorbed surgical sutures pretreated recombinant human type III collagen (RhCol III). vitro experiments confirmed that RhCol were successfully onto could be released expressed. vivo carried out using rat model simulating The section results showed compared scar group, expression level TGF-β3 III+TGF-β3 group increased by 39%, TGF-β1 decreased 62.8%, fibrosis rate 16.8%, which has positive effect on prevention This study integrates therapeutic into sutures, ensuring can come contact wound site after suturing. Moreover, work synergistically promote wounds.

Язык: Английский

Bovine serum albumin-modified prussian blue nanoparticles enhance wound healing through the promotion of skin angiogenesis

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106833 - 106833

Опубликована: Март 1, 2025

Язык: Английский