
Journal of Electrostatics, Год журнала: 2025, Номер unknown, С. 104083 - 104083
Опубликована: Апрель 1, 2025
Язык: Английский
Journal of Electrostatics, Год журнала: 2025, Номер unknown, С. 104083 - 104083
Опубликована: Апрель 1, 2025
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 284, С. 138201 - 138201
Опубликована: Ноя. 29, 2024
Язык: Английский
Процитировано
3ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Near-infrared (NIR) light-mediated photothermal and photodynamic therapies are promising for nonsurgical treatment of skin diseases. However, the skin's inherent light absorption, especially from melanin in epidermis, attenuates NIR energy penetration, limiting efficacy potentially causing off-target tissue damage. In this context, we developed subcutaneous response-enhanced microneedles (SLE MNs) that allow basal layer-localized seeding therapeutics leverage physical channels to efficiently transmit transdermally, facilitating situ scattered activation enhanced therapy outcomes. Such ultraoptical SLE MNs facilitated achieving up 80% initial power at 500 μm subcutaneously, representing an approximate 160% increase compared control groups. Additionally, conceptualized a two-segmented MN structure integrating light-guiding with photoresponsive enable precise basal-layer treatment, effectively mitigating local hyperenergy on surface attenuation within tissues. This optical patch offers transformative platform transdermal significant clinical potential.
Язык: Английский
Процитировано
0Journal of Electrostatics, Год журнала: 2025, Номер unknown, С. 104083 - 104083
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
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