Intradermal implantation of methotrexate-loaded puerarin-gelatin hydrogel via bubble-generating microneedles for psoriasis treatment

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 284, С. 138201 - 138201

Опубликована: Ноя. 29, 2024

Язык: Английский

Optical Microneedle-Enhanced Transdermal Light Scattering for In Situ Photothermal Therapy Targeting Basal-Layer Psoriasis

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Near-infrared (NIR) light-mediated photothermal and photodynamic therapies are promising for nonsurgical treatment of skin diseases. However, the skin's inherent light absorption, especially from melanin in epidermis, attenuates NIR energy penetration, limiting efficacy potentially causing off-target tissue damage. In this context, we developed subcutaneous response-enhanced microneedles (SLE MNs) that allow basal layer-localized seeding therapeutics leverage physical channels to efficiently transmit transdermally, facilitating situ scattered activation enhanced therapy outcomes. Such ultraoptical SLE MNs facilitated achieving up 80% initial power at 500 μm subcutaneously, representing an approximate 160% increase compared control groups. Additionally, conceptualized a two-segmented MN structure integrating light-guiding with photoresponsive enable precise basal-layer treatment, effectively mitigating local hyperenergy on surface attenuation within tissues. This optical patch offers transformative platform transdermal significant clinical potential.

Язык: Английский

A review on advancements in atmospheric plasma-based decontamination and drug delivery (invited paper)

Journal of Electrostatics, Год журнала: 2025, Номер unknown, С. 104083 - 104083

Опубликована: Апрель 1, 2025

Язык: Английский