Biocompatible nanoparticles self-assembled by PEGylated polyphosphoesters for combination of photodynamic therapy and hypoxia-activated chemotherapy against breast cancer DOI Creative Commons

Fengyu Wang,

Xiaojing Zou,

Chunyang Sun

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 23, 2024

Introduction Although photodynamic therapy (PDT) shows considerable potential for cancer treatment due to its precise spatial control and reduced toxicity, effectively eliminating residual cells under hypoxic conditions remains challenging because of the resistance conferred by these cells. Methods Herein, we synthesize an amphiphilic PEGylated polyphosphoester present a nanocarrier (NP CT ) specifically designed codelivery hydrophobic photosensitizer (chlorin e6, Ce6) hypoxia-activated prodrugs (tirapazamine, TPZ). We investigate antitumor effect NP on both cellular animal level. Results The efficient encapsulation Ce6 TPZ enables prolonged blood circulation improved tumor distribution agents. Upon internalization tumoral cells, 660 nm laser irradiation activates Ce6, leading generation reactive oxygen species (ROS) that kill murine 4T1 breast Meanwhile, PDT process consumes large amount generate microenvironment liberated from . resulting highly cytotoxic radicals target induce cytotoxicity in remaining Compared other groups, combination resulted most substantial growth inhibition. Discussion This innovative approach provides new avenues development advanced delivery systems based polyphosphoesters therapeutic strategies.

Язык: Английский

Controlling stimulus sensitivity by tailoring nanoparticle core hydrophobicity DOI Creative Commons
Xiao Zhang, Bowen Zhao, Shiwei Fu

и другие.

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This study introduces a novel and efficient approach for constructing stimulus-responsive polycarbonates with tunable stimulus sensitivity by tailoring nanoparticle core hydrophobicity.

Язык: Английский

Процитировано

1

Radioprotective Efficacy of Phosphorus-Containing Polymer Complexes of Amifostine WR-2721 DOI Creative Commons
Ivelina Tsacheva, Dzhamal Uzun

Scientia Pharmaceutica, Год журнала: 2025, Номер 93(2), С. 21 - 21

Опубликована: Апрель 29, 2025

Background: The aim of this study was to investigate the radioprotective efficacy polymer complexes constructed from amifostine (WR-2721) and poly(hydroxyoxyethylene phosphate)s with different molecular weights. use suitable polymers for immobilization drugs is aimed at improving or obtaining important new properties. Methods: compounds investigated by cytotoxicity survival mouse embryonic fibroblasts MEF LIG4+/+ LIG4−/− cells irradiated 2, 6 12 Gy in presence its complexes. Results: weights showed promising activity dose regimens. Conclusions: Cytotoxicity studies tested cell lines that were not toxic when equivalent doses drug applied cells. Irradiated demonstrated an increase surviving fraction pre-treated 0.5–5 mM irradiated. had increased Gy. These findings demonstrate are carriers (WR-2721). They further suggest they may be interesting researchers seeking challenges discovering advanced active substances.

Язык: Английский

Процитировано

0

Biocompatible nanoparticles self-assembled by PEGylated polyphosphoesters for combination of photodynamic therapy and hypoxia-activated chemotherapy against breast cancer DOI Creative Commons

Fengyu Wang,

Xiaojing Zou,

Chunyang Sun

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 23, 2024

Introduction Although photodynamic therapy (PDT) shows considerable potential for cancer treatment due to its precise spatial control and reduced toxicity, effectively eliminating residual cells under hypoxic conditions remains challenging because of the resistance conferred by these cells. Methods Herein, we synthesize an amphiphilic PEGylated polyphosphoester present a nanocarrier (NP CT ) specifically designed codelivery hydrophobic photosensitizer (chlorin e6, Ce6) hypoxia-activated prodrugs (tirapazamine, TPZ). We investigate antitumor effect NP on both cellular animal level. Results The efficient encapsulation Ce6 TPZ enables prolonged blood circulation improved tumor distribution agents. Upon internalization tumoral cells, 660 nm laser irradiation activates Ce6, leading generation reactive oxygen species (ROS) that kill murine 4T1 breast Meanwhile, PDT process consumes large amount generate microenvironment liberated from . resulting highly cytotoxic radicals target induce cytotoxicity in remaining Compared other groups, combination resulted most substantial growth inhibition. Discussion This innovative approach provides new avenues development advanced delivery systems based polyphosphoesters therapeutic strategies.

Язык: Английский

Процитировано

0