Controlling stimulus sensitivity by tailoring nanoparticle core hydrophobicity
Biomaterials Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
study
introduces
a
novel
and
efficient
approach
for
constructing
stimulus-responsive
polycarbonates
with
tunable
stimulus
sensitivity
by
tailoring
nanoparticle
core
hydrophobicity.
Язык: Английский
Radioprotective Efficacy of Phosphorus-Containing Polymer Complexes of Amifostine WR-2721
Scientia Pharmaceutica,
Год журнала:
2025,
Номер
93(2), С. 21 - 21
Опубликована: Апрель 29, 2025
Background:
The
aim
of
this
study
was
to
investigate
the
radioprotective
efficacy
polymer
complexes
constructed
from
amifostine
(WR-2721)
and
poly(hydroxyoxyethylene
phosphate)s
with
different
molecular
weights.
use
suitable
polymers
for
immobilization
drugs
is
aimed
at
improving
or
obtaining
important
new
properties.
Methods:
compounds
investigated
by
cytotoxicity
survival
mouse
embryonic
fibroblasts
MEF
LIG4+/+
LIG4−/−
cells
irradiated
2,
6
12
Gy
in
presence
its
complexes.
Results:
weights
showed
promising
activity
dose
regimens.
Conclusions:
Cytotoxicity
studies
tested
cell
lines
that
were
not
toxic
when
equivalent
doses
drug
applied
cells.
Irradiated
demonstrated
an
increase
surviving
fraction
pre-treated
0.5–5
mM
irradiated.
had
increased
Gy.
These
findings
demonstrate
are
carriers
(WR-2721).
They
further
suggest
they
may
be
interesting
researchers
seeking
challenges
discovering
advanced
active
substances.
Язык: Английский
Biocompatible nanoparticles self-assembled by PEGylated polyphosphoesters for combination of photodynamic therapy and hypoxia-activated chemotherapy against breast cancer
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 23, 2024
Introduction
Although
photodynamic
therapy
(PDT)
shows
considerable
potential
for
cancer
treatment
due
to
its
precise
spatial
control
and
reduced
toxicity,
effectively
eliminating
residual
cells
under
hypoxic
conditions
remains
challenging
because
of
the
resistance
conferred
by
these
cells.
Methods
Herein,
we
synthesize
an
amphiphilic
PEGylated
polyphosphoester
present
a
nanocarrier
(NP
CT
)
specifically
designed
codelivery
hydrophobic
photosensitizer
(chlorin
e6,
Ce6)
hypoxia-activated
prodrugs
(tirapazamine,
TPZ).
We
investigate
antitumor
effect
NP
on
both
cellular
animal
level.
Results
The
efficient
encapsulation
Ce6
TPZ
enables
prolonged
blood
circulation
improved
tumor
distribution
agents.
Upon
internalization
tumoral
cells,
660
nm
laser
irradiation
activates
Ce6,
leading
generation
reactive
oxygen
species
(ROS)
that
kill
murine
4T1
breast
Meanwhile,
PDT
process
consumes
large
amount
generate
microenvironment
liberated
from
.
resulting
highly
cytotoxic
radicals
target
induce
cytotoxicity
in
remaining
Compared
other
groups,
combination
resulted
most
substantial
growth
inhibition.
Discussion
This
innovative
approach
provides
new
avenues
development
advanced
delivery
systems
based
polyphosphoesters
therapeutic
strategies.
Язык: Английский