Biocompatible nanoparticles self-assembled by PEGylated polyphosphoesters for combination of photodynamic therapy and hypoxia-activated chemotherapy against breast cancer DOI Creative Commons

Fengyu Wang,

Xiaojing Zou,

Chunyang Sun

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 23, 2024

Introduction Although photodynamic therapy (PDT) shows considerable potential for cancer treatment due to its precise spatial control and reduced toxicity, effectively eliminating residual cells under hypoxic conditions remains challenging because of the resistance conferred by these cells. Methods Herein, we synthesize an amphiphilic PEGylated polyphosphoester present a nanocarrier (NP CT ) specifically designed codelivery hydrophobic photosensitizer (chlorin e6, Ce6) hypoxia-activated prodrugs (tirapazamine, TPZ). We investigate antitumor effect NP on both cellular animal level. Results The efficient encapsulation Ce6 TPZ enables prolonged blood circulation improved tumor distribution agents. Upon internalization tumoral cells, 660 nm laser irradiation activates Ce6, leading generation reactive oxygen species (ROS) that kill murine 4T1 breast Meanwhile, PDT process consumes large amount generate microenvironment liberated from . resulting highly cytotoxic radicals target induce cytotoxicity in remaining Compared other groups, combination resulted most substantial growth inhibition. Discussion This innovative approach provides new avenues development advanced delivery systems based polyphosphoesters therapeutic strategies.

Язык: Английский

Controlling stimulus sensitivity by tailoring nanoparticle core hydrophobicity DOI Creative Commons
Xiao Zhang, Bowen Zhao, Shiwei Fu

и другие.

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This study introduces a novel and efficient approach for constructing stimulus-responsive polycarbonates with tunable stimulus sensitivity by tailoring nanoparticle core hydrophobicity.

Язык: Английский

Процитировано

0
Biocompatible nanoparticles self-assembled by PEGylated polyphosphoesters for combination of photodynamic therapy and hypoxia-activated chemotherapy against breast cancer DOI Creative Commons

Fengyu Wang,

Xiaojing Zou,

Chunyang Sun

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 23, 2024

Introduction Although photodynamic therapy (PDT) shows considerable potential for cancer treatment due to its precise spatial control and reduced toxicity, effectively eliminating residual cells under hypoxic conditions remains challenging because of the resistance conferred by these cells. Methods Herein, we synthesize an amphiphilic PEGylated polyphosphoester present a nanocarrier (NP CT ) specifically designed codelivery hydrophobic photosensitizer (chlorin e6, Ce6) hypoxia-activated prodrugs (tirapazamine, TPZ). We investigate antitumor effect NP on both cellular animal level. Results The efficient encapsulation Ce6 TPZ enables prolonged blood circulation improved tumor distribution agents. Upon internalization tumoral cells, 660 nm laser irradiation activates Ce6, leading generation reactive oxygen species (ROS) that kill murine 4T1 breast Meanwhile, PDT process consumes large amount generate microenvironment liberated from . resulting highly cytotoxic radicals target induce cytotoxicity in remaining Compared other groups, combination resulted most substantial growth inhibition. Discussion This innovative approach provides new avenues development advanced delivery systems based polyphosphoesters therapeutic strategies.

Язык: Английский

Процитировано

0