INNOVATIVE ZEIN-DERIVED INKS: TOWARDS SUSTAINABLE 3D PRINTING SOLUTIONS
Results in Engineering,
Год журнала:
2025,
Номер
unknown, С. 104017 - 104017
Опубликована: Янв. 1, 2025
Язык: Английский
Enhanced Cell Proliferation, Migration, and Fibroblast Differentiation with Electrospun PCL–Zinc Scaffolds Coated with Fibroblast-Derived ECM
ACS Omega,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Despite
tremendous
improvement
in
the
development
of
tissue-regenerating
materials,
a
promising
solution
that
provides
an
optimal
environment
remains
to
be
accomplished.
Here,
we
report
composite
nanofiber
biomaterial
scaffold
as
closely
mimics
extracellular
matrix
(ECM)
improve
cell
viability,
proliferation,
and
migration.
Initially,
composites
polycaprolactone
(PCL)
zinc
(Zn)
metal
were
fabricated
by
using
electrospinning.
The
resulting
PCL–Zn
(PZ)
nanofibers
effectively
guided
growth
NIH3T3
fibroblasts
for
7
days,
forming
fibroblast
sheet.
PZ
fibers
decellularized
remove
autologous
allogenic
cellular
antigens
while
leaving
intact
ECM
with
structural
functional
components.
PCL–Zn–ECM
(PZE)
showcased
natural
bonded
surface,
providing
bioactive
element
interconnected
fibers.
reseeding
demonstrated
scaffold's
excellent
capacity
direct
support
proliferation.
Furthermore,
vitro
cytotoxicity
analysis
morphological
staining
confer
biocompatibility.
PZE
presents
which
these
scaffolds
can
further
used
various
regenerative
medicine
applications
including
wound
healing.
Язык: Английский
Fabrication of Zinc-Tryptophan Nanoassemblies for Antibacterial and Wound Healing Applications
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Язык: Английский
A Comprehensive Review of Quality Control and Reliability Research in Micro–Nano Technology
Nowshin Sharmile,
Risat Rimi Chowdhury,
Salil Desai
и другие.
Technologies,
Год журнала:
2025,
Номер
13(3), С. 94 - 94
Опубликована: Март 1, 2025
This
paper
presents
a
comprehensive
review
of
quality
control
(QC)
and
reliability
research
in
micro–nano
technology,
which
is
vital
for
advancing
microelectronics,
biomedical
engineering,
manufacturing.
Micro-
nanotechnologies
operate
at
different
scales,
yet
both
require
precise
to
ensure
the
performance
durability
small-scale
systems.
synthesizes
key
methodologies,
including
statistical
methods,
machine
learning
AI-driven
advanced
techniques
emphasizing
their
relevance
nanotechnology
applications.
The
also
discusses
application
micro/nanotechnology
other
technological
areas.
discussion
extends
unique
challenges
posed
by
systems,
such
as
failure
modes
related
stiction,
material
fatigue,
environmental
factors.
Advanced
testing
modeling
approaches
are
highlighted
effectiveness
predicting
mitigating
risks.
Additionally,
explores
integration
emerging
technologies
enhance
improve
By
examining
established
novel
techniques,
this
underscores
evolving
nature
field.
It
identifies
areas
future
investigation,
particularly
adaptation
these
methods
increasing
complexity
concludes
proposing
directions
that
can
further
optimize
continued
advancement
industrial
technologies.
Язык: Английский
Gallium Resistance in Staphylococcus aureus: Polymorphisms and Morphology Impacting Growth in Metals, Antibiotics and Polyfluorinated Compounds
Applied Microbiology,
Год журнала:
2025,
Номер
5(1), С. 32 - 32
Опубликована: Март 20, 2025
Background
and
Objectives:
The
imminent
threat
of
antibiotic
resistance
has
spurred
studies
nonconventional
antimicrobial
approaches.
Gallium
utilization
is
a
promising
emerging
approach
to
treating
variety
resistant
bacteria
using
“Trojan
horse”
strategies
disrupt
iron-dependent
processes
biofilms.
This
study
utilized
experimental
evolution
test
the
evolvability
gallium
in
Staphylococcus
aureus
traits
potentially
correlated
with
metals,
antibiotics
polyfluorinated
compounds,
as
well
its
genomics
foundations.
Methods:
Whole-genome
sequencing
was
reveal
functional
networks
mutations
associated
resistance.
Additionally,
scanning
electron
microscopy
(SEM)
observation
visualize
distinct
morphological
changes
on
surface
gallium-resistant
populations
compare
control
populations.
Results:
As
demonstrated
by
these
studies,
S.
evolved
after
20
days
selection.
Furthermore,
displayed
heavy
metals
compounds.
In
contrast,
were
very
sensitive
antibiotics.
analysis
revealed
significant
polymorphisms
(III)-resistant
for
example,
staphyloferrinA
export
MFS
transporter/D
ornithine
citrate
ligase
(sfaA/sfaD),
teichoic
acid
D
Ala
esterase
(fmtA),
DUF3169
family
protein
(KQ76_RS01520)
adenine
phosphoribosyltransferase
(KQ76_RS08360),
while
ABC
transporter
permease
subunit
(pstC)
acyltransferase
(KQ76_RS04365)
unique
directly
affected
cells’
morphology.
SEM
images
showed
external
ultrastructural
gallium-selected
bacterial
cells
compared
cells.
Conclusions:
Our
confirmed
that
an
can
have
health
environmental
implications.
Язык: Английский
Advanced healing potential of simple natural hydrogel loaded with sildenafil in combating infectious wounds
International Journal of Pharmaceutics X,
Год журнала:
2025,
Номер
unknown, С. 100328 - 100328
Опубликована: Март 1, 2025
Infected
wounds
are
common
clinical
injuries
that
often
complicated
by
inflammation
and
oxidative
stress
due
to
bacterial
invasion.
These
typically
suffer
from
impaired
vascularization,
which
delays
healing
increases
the
risk
of
complications
such
as
sepsis
chronic
wounds.
Therefore,
developing
an
effective
treatment
for
infected
is
highly
necessary.
Egg
white
can
promote
cell
regeneration
repair,
while
chitosan
in
resisting
Sildenafil
believed
have
potential
angiogenesis.
Based
on
these
properties,
we
prepared
a
new
type
hydrogel
using
egg
framework,
loaded
with
sildenafil
(CEHS).
The
combines
benefits
its
components,
exhibiting
good
biocompatibility
promoting
proliferation
migration
NIH
3T3
(3T3)
cells
human
umbilical
vein
endothelial
(HUVEC),
well
angiogenesis
HUVEC.
It
also
exhibits
significant
antioxidant,
anti-inflammatory,
antibacterial
properties
against
Escherichia
coli
(E.
coli)
Staphylococcus
aureus
(S.
aureus).
Additionally,
mouse
model
wounds,
CEHS
effectively
promoted
wound
through
excellent
antioxidant
anti-inflammatory
activity,
pro-angiogenic
effects.
In
summary,
this
simple-to-prepare,
multifunctional
natural
shows
great
promise
Язык: Английский
Development of Zinc-Containing Chitosan/Gelatin Coatings with Immunomodulatory Effect for Soft Tissue Sealing around Dental Implants
Tissue Engineering and Regenerative Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 23, 2024
Abstract
BACKGROUND:
Soft
tissue
integration
(STI)
around
dental
implant
abutments
is
a
prerequisite
to
prevent
bacterial
invasion
and
achieve
successful
rehabilitation.
However,
peri-implant
STI
major
challenge
after
abutment
placement
due
alterations
in
the
immune
microenvironment
upon
surgical
installation.
METHODS:
Based
on
known
immunomodulatory
effects
of
zinc,
we
herein
deposited
zinc/chitosan/gelatin
(Zn/CS/Gel)
coatings
onto
titanium
substrates
study
their
effect
macrophages.
First,
exposed
macrophages
cell
culture
media
containing
different
zinc
ion
(Zn
2+
)
concentrations.
Next,
explored
Zn/CS/Gel
prepared
via
facile
electrophoretic
deposition
(EPD).
RESULTS:
We
found
that
Zn
effectively
altered
secretome
by
reducing
secretion
pro-inflammatory
enhancing
pro-regenerative
cytokine
secretion,
particularly
at
supplementation
approximately
37.5
μM.
released
concentration
range
which
stimulated
macrophage
polarization
as
demonstrated
M2
polarization.
Additionally,
impact
these
-exposed
gingival
fibroblasts
incubated
conditioned
medium
showed
adhesion,
proliferation,
collagen
secretion.
CONCLUSION:
Our
promising
results
suggest
controlled
release
from
could
be
applied
immunomodulate
STI,
enhance
survival.
Язык: Английский
Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 33
Опубликована: Дек. 16, 2024
This
review
delves
into
the
efficacy
of
electrospun
nanofibers
as
structures
capable
neutralizing
Reactive
Oxygen
Species
(ROS),
thereby
aiding
in
acceleration
wound
repair.
ROS
occupy
a
dual
position
cellular
dynamics,
being
indispensable
for
intracellular
communication,
yet
they
potentially
exacerbate
oxidative
stress
which
can
stall
healing
trajectory.
The
method
electrospinning
synthesizes
distinguished
by
their
expansive
surface
area
relative
to
volume
and
notable
porosity,
rendering
them
optimally
suited
medical
endeavors,
particularly
frameworks
that
bolster
recuperation.
analysis
elucidates
diverse
roles
these
play,
from
enhancing
clot
formation
combating
microbial
invasion
mitigating
inflammation,
fostering
proliferation,
facilitating
angiogenesis—each
pivotal
component
effective
mending
wounds.
Язык: Английский