Highly Emissive Platinum(II) Metallacage in the Near-Infrared Region for Synergistic Chemo-Photodynamic Therapy DOI

Qifei Shen,

Kai Gao, Peijuan Zhang

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Highly emissive metallacages that generate reactive oxygen species (ROS) are important to synergistic cancer therapy, but it is still challenging balance the emission and phototheranostic properties. Herein, a metallacage of DTPABT-Mc prepared. It observed in near-infrared region from 600 1000 nm with high photoluminescence quantum yield value 7.92% solids recorded for DTPABT-Mc. In addition, ability produce both type I II ROS under light irradiation also observed, leading potential application photodynamic therapy (PDT) chemotherapy. After that, 4T1@DTPABT-Mc-NPs, covering nanoparticles 4T1 cell membranes, prepared enhance their tumor-targeting ability. This finally results effective therapeutic performance vivo, effectively inhibiting tumor growth. These suggest DTPABT-Mc-NPs exhibit excellent effects by combining PDT chemotherapy, providing new ideas design agents diagnosis future.

Язык: Английский

Thermally activated delayed fluorescence materials: innovative design and advanced application in biomedicine, catalysis and electronics DOI Creative Commons
Ehsan Ullah Mughal,

Syeda Fariha Kainat,

Abdulaziz M. Almohyawi

и другие.

RSC Advances, Год журнала: 2025, Номер 15(10), С. 7383 - 7471

Опубликована: Янв. 1, 2025

Thermally Activated Delayed Fluorescence (TADF) materials have emerged as a revolutionary class of functional compounds, driven by their unique ability to utilize excitons from both singlet and triplet states for efficient fluorescence emission. This manuscript provides an overview recent innovations in TADF material design, focusing on molecular strategies achieve optimal properties, including small singlet-triplet energy gaps (ΔE ST) high photoluminescence quantum yields. We explore the diverse applications materials, spanning OLEDs, biomedical imaging, photosensitizers, photocatalysis, UV photodetectors (UVOPDs), electrogenerated chemiluminescence, triplet-triplet annihilation (TTA) sensitizers, organic hybrid microwire radial heterojunctions, multicolor luminescent micelles, mechano-luminescence (ML), light-emitting electrochemical cells (LEECs), fluorescent probes. The integration these technologies highlights potential enhance performance efficiency. Through this review, we aim elucidate fundamental principles governing behavior present forward-looking perspective synthetic methodologies new, versatile materials.

Язык: Английский

Процитировано

1

Highly Emissive Platinum(II) Metallacage in the Near-Infrared Region for Synergistic Chemo-Photodynamic Therapy DOI

Qifei Shen,

Kai Gao, Peijuan Zhang

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Highly emissive metallacages that generate reactive oxygen species (ROS) are important to synergistic cancer therapy, but it is still challenging balance the emission and phototheranostic properties. Herein, a metallacage of DTPABT-Mc prepared. It observed in near-infrared region from 600 1000 nm with high photoluminescence quantum yield value 7.92% solids recorded for DTPABT-Mc. In addition, ability produce both type I II ROS under light irradiation also observed, leading potential application photodynamic therapy (PDT) chemotherapy. After that, 4T1@DTPABT-Mc-NPs, covering nanoparticles 4T1 cell membranes, prepared enhance their tumor-targeting ability. This finally results effective therapeutic performance vivo, effectively inhibiting tumor growth. These suggest DTPABT-Mc-NPs exhibit excellent effects by combining PDT chemotherapy, providing new ideas design agents diagnosis future.

Язык: Английский

Процитировано

0