Rational design of AIEgens for specific dual-targeting and efficient eradication of multidrug-resistant bacteria: Insights into charge, chain length, and bacterial binding

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161664 - 161664

Опубликована: Март 1, 2025

Язык: Английский

Enlarged Cleavable Linkages in Shuriken-like Quaternary Ammonium Compounds Providing Safer Bactericides

Chemistry of Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Although they offer great convenience in preventing microbial infections, the nondegradable feature of most commercial quaternary ammonium compounds (QACs) has led to persistent environmental accumulation, raising significant concerns about their detrimental impacts on public and ecological health. In this study, we report a kind shuriken-like QACs with rapid hydrolysis properties under mild conditions, enabled by introduction enlarged cleavable linkages as backbones. Such present potent bactericidal activity owing multicationic "heads" yet can be converted entirely harmless forms choline silicone oil after degradation. Both cytotoxicity assessment biosafety evaluation confirm nontoxic nature degradation products. The performance fruit preservation infection prevention fabric surfaces further illustrates broad application prospects such degradable within realm food safety With advantages hydrolysis, friendliness, low biotoxicity, concept an "enlarged linkage" strategy will pave way for exploiting generation disinfectants that effectively combat threats while ensuring minimal footprint.

Язык: Английский

Designed amino acid-based deep eutectic solvents as a platform to functionalize biomedical elastomers by polyaddition reactions

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162605 - 162605

Опубликована: Апрель 1, 2025

Язык: Английский